Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Preclinical study of anti-IL8 in endometriosis:
"We created a long-acting recycling antibody against IL-8 (AMY109) and evaluated its clinical potency. Because rodents do not produce IL-8 and do not experience menstruation, we analyzed the lesions in cynomolgus monkeys that spontaneously developed endometriosis and in a surgically induced endometriosis monkey model."
#Immunology #monoclonalantibodies #Endometriosis #inflammation
Thiago Carvalho
boosted
Thiago Carvalho
boosted
Origin and Evolution of Marsupial-specific Imprinting Clusters Through Lineage-specific Gene Duplications and Acquisition of Promoter Differential Methylation https://doi.org/10.1093/molbev/msad022 #science #evolution #biology #genome #SciComm #evolgen_paper
Thiago Carvalho
boosted
Mitonuclear Interactions and the Origin of Macaque Societies https://doi.org/10.1093/gbe/evad010 #science #evolution #biology #genome #SciComm #evolgen_paper
'Apart from trans-acting protein factors, recent evidence points to a role of different RNA species in targeting repressive histone marks and DNA methylation to these sites in mammals. Here, we review recent discoveries on this topic and predominantly focus on the role of RNA methylation, piRNAs, and other localized satellite RNAs.'
Thiago Carvalho
boosted
Gerhard Richter, Untitled from Canary Landscapes (Kanarische Landschaften), 1970–71 #museumarchive #museumofmodernart http://www.moma.org/collection/works/66509
"Smith was first and foremost an Enlightenment thinker who sought to empower humanity to reshape and reimagine the world. The utopian rigor of market thought would have cut against his entire method and approach to social and economic life—especially his democratic sensibilities, his feeling that there was no single order that could be imposed on all of society."
"Because of the important role of the ENS in controlling intestinal functions, it is not surprising that changes in ENS development and function are connected to intestinal microbiota dysbiosis in various human disorders"
https://journals.physiology.org/doi/full/10.1152/ajpgi.00166.2022
Thiago Carvalho
boosted
RT @CyrilPedia
My latest Clinical Pipeline column is out, a look at an anti-FcRn monoclonal for severe hemolytic disease of the fetus and newborn https://twitter.com/NatureMedicine/status/1630906381376135169
Thiago Carvalho
boosted
Online now: Can herbivores sharing the same host plant be mutualists? https://www.cell.com/trends/ecology-evolution/fulltext/S0169-5347(23)00026-5?rss=yes&utm_source=dlvr.it&utm_medium=mastodon
The Torremolinos model of human evolution:
"Like retirees who flock to the Costa del Sol, ancient European hunter-gatherers sought out Spain’s warmer climate during the peak of the last ice age."
'Here, we investigated the generality, specificity and mechanistic basis of immune priming in the fruit fly Drosophila melanogaster when infected with the gram-negative bacterial pathogen Providencia rettgeri.'
Thiago Carvalho
boosted
PNAS outlines its policy for the use of text generated by ChatGPT et al in papers. Not clear what the process will be if the AI is an Academy Member.
https://www.pnas.org/post/update/pnas-policy-for-chatgpt-generative-ai
Thiago Carvalho
boosted
Last fall I spoke with @MarkHanson, who was then in Bruno Lemaitre's lab, for EMBO's @ReviewCommons platform for refereed #preprints. I love this detail about how flies grow - I picture a tiny little bicycle pump in there somewhere:
'When flies eclode from the pupa they are soft and squishy and they “manually” inflate their wings by pumping air through their body and that inflates the cuticle in a way that there is room for the body to move around inside that shell.'
#Drosophila #InnateImmunity
https://www.reviewcommons.org/blog/models-oddballs-and-preprints-a-conversation-with-mark-hanson/
Thiago Carvalho
boosted
Enter the Red Queen.
"Eric Mitchell, a graduate student at Stanford University, figured a classifier would take a lot of training data. Along with colleagues, he came up with DetectGPT, a “zero-shot” approach to spotting the difference, meaning the method requires no prior learning. Instead, the method turns a chatbot on itself, to sniff out its own output."
https://www.ft.com/content/e34c24f6-1159-4b88-8d92-a4bda685a73c
Thiago Carvalho
boosted
'Because mink are known to spread certain viruses to humans, the fear was that the disease could jump from mink to people. No humans got sick from the outbreak in Spain, but other infections have spread from mink to humans before: In 2020, COVID outbreaks on Danish mink farms led to new mink-related variants that spread to a small number of humans.'
https://www.theatlantic.com/health/archive/2023/02/mink-farm-bird-flu-virus-infection-spread/673236/
Thiago Carvalho
boosted
Online now - our 2023 issue 5:
Activation of #plant #NLR #immune receptors
#Stereoisomer specificity in #flagellin #sialylation
Dormant #ribosome activation by #TORC1
#Cytomegaloviral #DCAF for #cullin-mediated #STAT2 degradation
Cover: Korolchuk lab
https://www.embopress.org/toc/14602075/2023/42/5
"But the oldest DNA of modern humans in Europe, dating back 45,000 years, undermines such a simple story. It comes from people who belonged to a lost branch of the human family tree. Their ancestors were part of the expansion out of Africa, but they split off on their own before the ancestors of living Europeans and Asians split apart."
https://www.nytimes.com/2023/03/01/science/dna-hunter-gatherers-europe.html
@AstroKatie As the prime mover, I'll with awe
Thiago Carvalho
boosted
Have 5 minutes? Then you have time to support preprints! ⏲️
PDF version: https://buff.ly/3KKqGTF
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
