Thiago Carvalho @cyrilpedia@qoto.org

"However, we find that there is consistently a stronger relationship between mRNA abundance and gene sensitivity than there is between regulatory gene activity and gene sensitivity. This is true both when gene sensitivity is treated as a binary and a quantitative property. Overall, our results suggest that gene sensitivity is better predicted by measured expression than by GRN-inferred activity."

#preprint

https://www.biorxiv.org/content/10.1101/2023.03.02.530664v2

'Blockade of the inhibitory FcγRIIB in combination with anti–PD-L1 improved antitumor responses. Similarly, afucosylation of the IgG1 Fc region improved antitumor responses, and this was due to alterations in the tumor microenvironment.'

#immunology #immunotherapy #glycosylation

https://www.science.org/doi/10.1126/sciimmunol.add8005

When your frenemies get the last word.
(from "Apropos of Nothing in the NYRB https://www.nybooks.com/articles/2022/07/21/absence-and-nothing-stephen-mumford/ )

My favorite case in the history of biology is Cuvier's eulogy of Lamarck, which you can read 👇

https://victorianweb.org/science/science_texts/cuvier/cuvier_on_lamarck.htm

A tiger for art lovers and Clive Barker fans by @hunchbacksociety

#ceramics #ceramic #ceramicart #handmade #ArtMastodon

https://madalenaparreira.com/Hunchbacksociety

I can't believe I missed this podcast last year: Ta-Nehisi Coates on Tony Judt
cc @mucida
🎧 👇

https://www.publicbooks.org/primary-sources-ta-nehisi-coates-on-tony-judt/

'Tingible body macrophages (TBMs) are tasked with apoptotic cell clearance to prevent secondary necrosis and autoimmune activation by intracellular self antigens. We show by multiple redundant and complementary methods that TBMs derive from a lymph node-resident, CD169-lineage, CSF1R-blockade-resistant precursor that is prepositioned in the follicle.'

#immunology #Macrophage #Apoptosis #GerminalCenter

https://www.cell.com/cell/fulltext/S0092-8674(23)00106-X

'Here we propose best practices, quality controls and data-reporting recommendations to assist in the broad adoption of reliable quantitative workflows for single-cell proteomics. Resources and discussion forums are available at https://single-cell.net/guidelines.'

https://www.nature.com/articles/s41592-023-01785-3

"10. Try to leave out the part that readers tend to skip. Think of what you skip reading a novel: thick paragraphs of prose you can see have too many words in them."

https://www.theguardian.com/books/2010/feb/24/elmore-leonard-rules-for-writers

'There are many matrilineal societies—organized through mothers rather than fathers, with name and property passed from mother to daughter—around the world. In some regions, matrilineal traditions are thought to date back thousands of years.'

https://www.nationalgeographic.com/history/article/angela-saini-patriarchy-matriarchy-gender-equality

When elephants are not like E. coli:

“That time was the beginning of cloning of human genes. She (Shirley Tilghman) cloned the beta globin gene. People went to listen to her seminar (at the NIH) and she presented this amazing discovery that when looking at the electron microscope of the hybridization of the globin message and the gene that they had cloned, there was a piece of the gene that was not in the message.”

From the #EMBOPodcast with Roberto di Lauro, who was a group leader at the EMBL, a professor at the University of Naples Federico II, served as President of the Stazione Zoologica Anton Dohrn, and the scientific attaché to the Italian Embassy in London.
#EMBOPodcast

https://www.embo.org/podcasts/we-should-know-more-this-is-our-main-job/

'Here’s a new paper that tries to answer the sort of question that anyone who thinks about the evolution of living systems has asked: why do we have the biochemistry that we have? And by “we”, I mean “every single living thing on Earth”.'

https://www.science.org/content/blog-post/why-these-amino-acids-anyway

'Esse processo de radicalização está em curso em Portugal e não é simétrico: manifesta-se na direita com grande agressividade e não tem paralelo à esquerda. Por muito que se procure dizer aquelas platitudes equilibradas sobre a radicalização dos dois lados, ela não existe. Nos EUA é a mesma coisa, não é o Black Lives Matter que pode ser comparado ao ascenso do trumpismo e à sua consolidação num dos grandes partidos da democracia americana, o Partido Republicano, muito para além de Trump.'

https://www.publico.pt/2023/03/04/opiniao/opiniao/radicalizacao-assimetrica-2041086

'This irony recurs in his letters: Le Carré repeatedly offers withering indictments of the powers he served, but he never seems to cast them aside. Later in life, he wrote nostalgically to Alan Judd, a fellow novelist who once served as a soldier and diplomat, of his time at MI5 and MI6: “I miss the Office … In a sense, they are the only places, apart from writing.”

https://www.theatlantic.com/books/archive/2023/02/john-le-carre-spy-came-in-from-cold-book/673227/