Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
"Psychologists in particular wanted a statistical skeleton key to unlock true experimental insights. It was an unrealistic burden to place on statistics, but the longing for a mathematical seal of approval burned hot."
https://www.sciencenews.org/article/statistical-significance-p-value-null-hypothesis-origins
Thiago Carvalho
boosted
The Republican billionaire donors using anti-trans talking points to buy the bigoted evangelical voting block are about to lose their minds. Yay.
https://www.nytimes.com/2023/01/25/us/politics/transgender-laws-republicans.html
Thiago Carvalho
boosted
Classic Radiohead Songs Re-Imagined as a Sci-Fi Book, Pulp Fiction Magazine & Other Nostalgic Artifacts
Thiago Carvalho
boosted
It's a bumper news month for next generation Covid vaccines!
My @PLOS Update 11 is online now:
- Govt support for 2 vaxes, in Japan & US - $$$ hundreds of millions
- Encouraging early phase 2 trial results for immunocompromised people on blood cancer treatment
- Another Covid nasal spray vax into clinical trial (USA)
- First large study on nasal Covid vax to prevent infection underway in China
Plus more clinical & preclinical results:
'However, as Keller would often emphasize later on, this approach did not mean that McClintock was pursuing science in a distinctively feminine way, either. Instead, as Horning notes, Keller’s aim, stated in “Reflections on Gender and Science,” was the “reclamation, from within science, of science as a human instead of a masculine project.”
https://news.mit.edu/2023/professor-emerita-evelyn-fox-keller-dies-0925
"Further, when CART cells were treated with IL-4, they developed signs of exhaustion, but when CART cells were treated with an IL-4 monoclonal antibody, they showed improved antitumor efficacy and reduced signs of exhaustion in preclinical models."
Thiago Carvalho
boosted
Aardvark in progress by @hunchbacksociety
https://madalenaparreira.com/Hunchbacksociety
#Ceramics #Handmade #Art #stoneware #artgallery #artmastodon
"After realising that many notable women working in science, technology, engineering and maths (Stem) and others from minority backgrounds did not have Wikipedia pages, though they were deserving of them, she decided to start them herself, one every day. Each one takes “a few hours” to write, she says. It’s a task, she confesses, that she somehow completes while simultaneously watching real estate shows on Netflix in the evening. To date, she has contributed more than 2,000 entries."
Thiago Carvalho
boosted
At this point, I fear we might only be weeks away from Musk tweeting "you know, Hitler had a point..."
Elon Musk Attacks German Support for Migrants, Boosts Far-Right Extremists
https://www.businessinsider.com/elon-musk-immigration-migrants-germany-far-right-extremism-twitter-x-2023-9
Thiago Carvalho
boosted
Merck filed a biologics license application for sotatercept in pulmonary arterial hypertension & now the FDA has granted it priority review.
https://www.merck.com/news/merck-receives-priority-review-from-fda-for-new-biologics-license-application-for-sotatercept-an-activin-signaling-inhibitor-to-treat-adults-with-pulmonary-arterial-hypertension-pah/
I wrote about the drug last fall for Nature Medicine:
"BMPR-II regulates apoptosis and has anti-proliferative effects on pulmonary smooth muscle and endothelial cells. Sotatercept should assist BMPR-II in its tug-of-war with another TGF-beta family member, ActRIIA (which promotes proliferation), by selectively trapping activin pathway ligands. Unlike existing therapies that provide symptomatic management, sotatercept has the potential to be a curative treatment for pulmonary arterial hypertension by modifying the underlying causes of the disease."
Thiago Carvalho
boosted
"Salmonella Typhimurium mutants for spermidine transport and synthesis cannot mount an antioxidative response, resulting in high intracellular ROS levels. These mutants are also compromised in their ability to be phagocytosed by macrophages"
#Microbiology #Preprint #Salmonella #MucosalImmunology #immunology
https://www.biorxiv.org/content/10.1101/2023.09.29.560257v1?med=mas
Thiago Carvalho
boosted
“It became the custom in such cases to give credit solely to the one who actually made the experiment work, even if others may have also conceived the idea. It was the drosophilists’ golden rule. Ideas that were engendered in the group’s informal shoptalk were treated as communal resource and not as personal property.”
(Robert E. Kohler, Lords of the Fly)
#Books #Bookshelf #ScienceHistory #SciComm #Drosophila #bookstodon
Thiago Carvalho
boosted
Thiago Carvalho
boosted
Tomorrow morning the Noble Prize in Physiology or Medicine will be announced.
The new Ground Truths makes the case for transformer model #AI as having made an essential contribution for the recent Lasker "American Nobel" Award and throughout life science
https://erictopol.substack.com/p/a-new-precedentai-gets-the-american
Thiago Carvalho
boosted
Thiago Carvalho
boosted
@andrewplested Thanks - clearly time to re-read it!
Thiago Carvalho
boosted
Research(er) assessment that considers open science - Leiden Madtrics https://www.leidenmadtrics.nl/articles/researcher-assessment-that-considers-open-science
Thiago Carvalho
boosted
'Similarly, the poorest communes have generally voted much more for the left, especially in cities. That remains true to the present day. The (often intentional) confusion comes from the fact that commentators tend to associate the working classes only with blue-collar manufacturing workers, forgetting that the average wage of supermarket cashiers, restaurant staff, cleaners, care workers and other service industry employees has fallen below that of manufacturing workers for several decades now.'
Thiago Carvalho
boosted
'These episodes made me experience first-hand a phenomenon that I was becoming increasingly familiar with: the vanishing of confidence in science. It seems almost a paradox: as our societies become more and more dependent on advanced technology based on scientific discoveries, people are becoming more and more suspicious of scientists.'
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
