Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Tools:
"Here we show that the yields of edited primary human lymphocytes can be increased substantially by delivering a CRISPR ribonucleoprotein mixed with an amphiphilic peptide identified through screening. We evaluated the performance of this simple delivery method by knocking out genes in T cells, B cells and natural killer cells via the delivery of Cas9 or Cas12a ribonucleoproteins or an adenine base editor."
#CRISPR #crisprcas9 #geneediting
'In this study, we report that high CDK6 expression positively correlates with immunotherapy resistance in 6 of 7 single-agent immunotherapy clinical studies for melanoma patients. CDK6 depletion, but not that of CDK4, cyclin D1, or D2, in cells of the TME inhibits tumor growth.'
#immunotherapy #immunology
https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00325-X
Thiago Carvalho
boosted
Next in our 'Lab meeting' series is the Ashe lab at the University of Manchester, UK!
The lab investigates how cell signalling and gene expression dynamics control developmental patterning, using #Drosophila embryo and ovarian germline stem cells as models. #devbio
Meet the lab: https://thenode.biologists.com/lab-meeting-with-the-ashe-lab
"It was only toward the middle of the twentieth century that the inhabitants of many European countries came, in general unpleasantly, to the realization that their fate could be influenced directly by intricate and abstruse books of philosophy."
Czeslaw Milosz, The Captive Mind.
Thiago Carvalho
boosted
Postdoctoral Fellow in mammalian regeneration @AntoineZalc
Interested in mechanisms regulating cell fate and plasticity during development and regeneration?
Want to do good and fun science in beautiful Paris?
#ScienceJobs ...
https://jobrxiv.org/job/institut-cochin-27778-postdoctoral-fellow-in-mammalian-regeneration/?feed_id=43734
Thiago Carvalho
boosted
Rosalind Franklin update!
“A new paper based on long-lost documents confirms that DNA discoverer Rosalind Franklin should be credited for discovering the double helix.”
https://www.livescience.com/health/genetics/rosalind-franklin-knew-dna-was-a-helix-before-watson-and-crick-unpublished-material-reveals?fbclid=IwAR3AhaUWlB4QejBW6ESk1IAn-IPKqF8PUUs4KHPbZ2jMnQcCgCDcGPOjA74#lgymp4kotadc1a3pafg #HistoryRemix #history #science /2
Thiago Carvalho
boosted
Scientists say millions more will develop Parkinson's disease a result of their covid infection, with the finding that covid has caused an astonishing rise in dream-enactment-sleep-disorder - a precursor of Parkinson's disease.
Over the whole of the population we would expect to see millions more develop Parkinson's disease than would have if not for their COVID infection," said Richard Smeyne, Chair of the Department of Neuroscience at Thomas Jefferson University.
Thiago Carvalho
boosted
“The Kiss of Death” from Poblenou Cemetery, Barcelona. An inscription reads: "So his youthful heart is fading. In his veins his blood is freezing, and all strength has slipped away. Faith is leveled as he falls into the arms of Death. Alas!” Photo: Stephan Harmes.
If you're studying/generating IgG antibodies from species other than human & mouse but plan to use your abs on these organisms, this EJI might help your experimental design.
'In this review, we focus on systems-level methods of immunometabolism that connect immune (and nonimmune) cells in tissues via metabolic communications and reveal cellular and functional heterogeneity of immunometabolic circuits.'
#Immunology #Metabolism
https://www.annualreviews.org/doi/full/10.1146/annurev-immunol-101220-031513
'I do know that I started noticing a change in my own reading habits – I'd get online and look up and 40 minutes would have gone by, and my reading time for the night would have been pissed away, and all I would have learned was that, you know, a certain celebrity had lived in her car awhile, or that a cat had dialled 911.'
https://www.theguardian.com/books/2013/apr/22/george-saunders-my-desktop-time-100?ref=thebrowser.com
Thiago Carvalho
boosted
The field of synthetic biology has come a long way in the past 20 years. In this Perspective, @MatthewWChang &co at @nus_syncti look at how #machinelearning could help synthetic biology to achieve greater heights. #synbio
https://plos.io/3LbB7y6
Thiago Carvalho
boosted
RT @williamnhutton
Ultra expensive housing is killing our civilisation- denuding cities of the young, making starting families ever harder, impacting the birth rate and hitting economic growth and social mobility. Hear Polly Neate on the We Society podcast set out the issues - and some answers https://twitter.com/acadsocsciences/status/1651499251585744897
Thiago Carvalho
boosted
RT @denis_mogilenko
Systems Immunology Approaches to Metabolism – check out our new review in @AnnualReviews of Immunology! We discuss recent studies highlighting the complex physiological interplay between immune responses and metabolism.
https://www.annualreviews.org/doi/abs/10.1146/annurev-immunol-101220-031513
Thiago Carvalho
boosted
RT @solana_jordi
Proudly presenting our new bioRxiv:
The cell type atlas of the regenerating and asexually reproducing annelid Pristina leidyi
We show that a piwi+ cell population with a pluripotent stem cell signature underlies adult differentiation
https://www.biorxiv.org/content/10.1101/2023.04.25.537979v1
A tweetorial 🧵👇
Thiago Carvalho
boosted
Aquatint & chine-collé with colours added through viscosity printing by @madparreira
https://madalenaparreira.com/Aquatints
#Prints #Printmaking #Print #artofinstagram #Aquatint
#Handmade #chinecollé #artmastodon
Thiago Carvalho
boosted
PhD position - Molecular mechanisms of airway mucin secretion
PhD opportunity - Molecular mechanisms of airway mucin secretion
#ScienceJobs #job
Ulm #Germany #PhDStudent
https://jobrxiv.org/job/university-of-ulm-27778-phd-position-molecular-mechanisms-of-airway-mucin-secretion/?feed_id=43722
Thiago Carvalho
boosted
An Interlude in Microbiology
by Elio
If before 1950 you had asked "are bacteria cells?" the chances are that you would be told "it depends…" In other words, no one knew for sure. It took Joshua Lederberg, who, upon discovering mating in E. coli, proposed that bacteria were indeed cells...
Read more → https://schaechter.asmblog.org/schaechter/2023/04/an-interlude-in-microbiology.html
Thiago Carvalho
boosted
Corvos imaginários, papagaios estocásticos e outros animais que falam, de Manuel Arriaga, pretende apresentar algumas ideias em torno do tema ChatGPT, indo um pouco além das discussões que geralmente se encontram nos media:
https://almanaquemag.com/corvos-imaginarios-papagaios-estocasticos-e-outros-animais-que-falam/
📸 Alessio Ferretti
#almanaque #almanaquemag #manuelarriaga #chatgpt
Thiago Carvalho
boosted
SSB is launching a new mentorship program to cultivate relationships among members of the systematics and phylogenetics community.
We're now recruiting a pool of mentees and mentors for our first group of participants!
Learn more: https://www.systbio.org/mentoring-program.html
Enroll here: https://forms.gle/mc2gPDwaTGYvcR1k7
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
