Thiago Carvalho @cyrilpedia@qoto.org

For #throwbackthursday, a blog post from 2013 by Washington University's Joan Strassmann, on the IGC PhD course she participated in as guest faculty back when I was running the PhD program.

https://sociobiology.wordpress.com/2013/05/05/journal-club-extended-to-research-planning-for-students-at-the-gulbenkian-in-portugal/

"The rabbits’ “interracial” union had inflamed Montgomery's chapter of the White Citizens’ Council, whose members argued that the book amounted to grooming by literary means, conditioning preschoolers to cross the color line. Essentially a white-supremacist chamber of commerce, with a fast-growing network across the South in the wake of the U.S. Supreme Court’s Brown v. Board of Education desegregation decision in 1954, the council used its dollars and clout to stoke economic intimidation and violence against the burgeoning civil rights movement. These segregationists were ideological ancestors of today’s book challengers, such as those in a Florida school district that recently banned “And Tango Makes Three,” about two male chinstrap penguins who create a family. Across time, those who ban books have shared a deep aversion to anything that promotes changing definitions of marriage and family."

https://www.nytimes.com/2023/04/26/books/review/garth-williams-the-rabbits-wedding-banned-books.html

'What’s your favorite book no one else has heard of?

“The Citadel,” by A.J. Cronin, isn’t as well known in America as in Britain and the Commonwealth. The oppressive conditions described in the fictional Welsh mining town so captivated the public’s imagination that it ostensibly shares responsibility for the creation of the National Health Service. A generation of physicians outside of America name “The Citadel” as the book that called them to medicine.'

https://www.nytimes.com/2023/04/27/books/review/abraham-verghese-by-the-book-interview.html

"However, T cell responses to dietary antigen have primarily been characterized using monoclonal T cell receptor (TCR) transgenic systems which do not represent a physiological immune response. Polyclonal CD4+ T cell responses to food, including TCR-specific selection and functional differentiation, remain largely uncharacterized and are critical for understanding mechanisms of tolerance and allergy."
Lockhart, @mucida et al

#Preprint #Immunology #OralTolerance #MucosalImmunology

https://www.biorxiv.org/content/10.1101/2023.04.11.536475v1

"Map 11 The Two Ladies (Leiden, Netherlands, circa 1790)

The Two Ladies is a direct reaction to the vision of medicine put forward by the Encyclopedists, particularly in d’Alambert’s treatise on the primacy of sensory knowledge and experimentation, the Discours préliminaire. The two female figures are a not-even-thinly veiled insult directed at Diderot & d'Alembert (it was a time of rampant misogyny and Dutch humor remains to this day, as they say, no laughing matter). The image is not a map but rather a chart of sorts, with texts of Galen’s prescribed treatments overlaid on the corresponding afflicted body parts. The Margrave brought a copy of this print with him to Kaiserslautern in 1933, but it is not known if Galen’s typology of human temperament played any part in von Willebrand’s course of treatment."
#Prints #Printmaking #Print #Handmade #Maps #Cartography #artgallery #artmastodon

https://madalenaparreira.com/SPAM

' En su popularísima serie de televisión Cosmos, Carl Sagan trató la muerte de Hipatia así: “En el año 415, cuando iba a trabajar, cayó en manos de una turba fanática de feligreses de Cirilo. La arrancaron del carruaje, rompieron sus vestidos y, armados con conchas marinas, la desollaron arrancándole la carne de los huesos. Sus restos fueron quemados, sus obras destruidas”.

https://elpais.com/ideas/2023-04-27/hipatia-de-alejandria-la-pop-star-de-la-antiguedad-que-resiste-al-olvido.html

'The review correctly identifies a multitude of factors that have led to a decline in clinical trials, including the pressures on the Medicines and Healthcare products Regulatory Agency, which has a reduced capacity and increased workload post-pandemic and post-Brexit, and other aspects of the national and local trial approvals systems, which have undermined the competitiveness of the UK clinical research environment.'

https://www.theguardian.com/commentisfree/2023/apr/26/britain-covid-research-clinical-trials-nhs-doctors?CMP=share_btn_tw

A long & winding road.

"However, our efforts to identify a chemical inhibitor of apoptosis floundered. Whatever we tested either did not work or had only a marginal effect. We wondered whether components of the pathway might have built-in redundancies. If so, the project was dead."
#Apoptosis #CellDeath

https://www.science.org/doi/10.1126/sciadv.adi2011#.ZEmbzTtPNQI.twitter

'To do so, cast your mind back to high school chemistry and Boyle’s Law. That Law was just one of Robert Boyle’s accomplishments, for he was a pillar of the Scientific Revolution. In fact, his book The Sceptical Chymist is generally considered to mark the dawn of modern chemistry, the science of how things are constituted. A friend to both Highmore and Digby, Boyle had read their work, and when his own magnum opus was published some ten years after theirs, Boyle noted a key implication of his new chemistry: to “teach us how a Chick is formed in the Egge.”'

https://thenode.biologists.com/devbiolstories-guy-fawkes-chickens-and-the-hatching-of-mechanism-in-developmental-biology/research/