Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
@cyrilpedia
What an interesting paper, thank you for sharing.
The data and experiments look very solid. One comment - fig 1c is doing quite a lot of the heavy lifting in showing the specific induction of IL-24. Looks fair but how often is an injury just epidermis deep? If you get dermal injury, then IL-1b looks almost as specific a cytokine induced. Anyway, that's a separate story. IL-24 as an important local skin danger signal, I'm sold.
Thiago Carvalho
boosted
Today the government’s anti-democratic mission is seen clearly. As well as suppressing dissent through draconian anti-protest laws, the Met used live facial recognition surveillance during the coronation.
These are the tactics of authoritarian regimes.
In a democracy, protest is a fundamental right. #protest #coronation #policing #humanrights
https://time.com/6277591/anti-monarchy-protesters-arrested-king-charles-coronation/
Thiago Carvalho
boosted
Just in case anyone didn’t know, the police are currently arresting anyone peacefully protesting against the coronation and its lavish extravagance during a time of national need.
Currently. Arresting. Peaceful. Protestors.
This is not my country. This is a dystopia.
Thiago Carvalho
boosted
Thiago Carvalho
boosted
'These distinct roles for EZH2 in promoting prostate cancer progression, metastasis, and AR independence raise the possibility that it could be a potential therapeutic target in advanced disease.'
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002038
Thiago Carvalho
boosted
Born in 1902, botanist & cytogeneticist Barbara McClintock became a pioneer in modern genetics by changing our understanding of inheritance.
She proposed that genomic replication does not always follow a consistent pattern, which wasn’t widely accepted at the time. She also contributed new cytogenetic research techniques & was the first scientist to correctly speculate about epigenetics.
In 1983, McClintock was awarded a Nobel Prize. https://www.nobelprize.org/womenwhochangedscience/stories/barbara-mcclintock #HistoryRemix #science #history
Thiago Carvalho
boosted
"Menopause costs American women an estimated $1.8 billion in lost working time per year, according to a Mayo Clinic study published this week. The paper examined how hot flashes, night sweats, mood swings and the myriad other symptoms associated with this time of life affect women in the workplace. It’s the largest study of its kind to have been done in the United States."
Thiago Carvalho
boosted
'The European People’s party, which has the most seats in the European parliament and is in power in nine countries across the EU, will call on Friday to scrap two flagship pieces of legislation put forward by their own European Commission president, Ursula von der Leyen. The move could torpedo the commission’s plans to cut pesticide use in half and rewild a fifth of damaged habitats across the bloc by 2030.'
https://www.ft.com/content/38f5801e-a68c-4328-b467-a07ee7fbd94d
@mucida The paper also has a very interesting evolutionary scenario
"Unbiased phylogenetic analyses indicated that this family and its receptors28 share greater sequence/structure homology to IFN and IFN-receptors than other cytokines/cytokine-receptors (Figures S1A and S1B; Table S3). Notably, the heterodimeric receptor subunits of the IFN and IL-10 families also sub-clustered, suggestive of a common ancestral heterodimeric receptor specific to these two families (Figure S1B). In contrast to IFNs, however, the IL-10 cytokine family has not been as clearly linked to pathogens/danger signals. This raises the tantalizing possibility that, during evolution, these pathways may have bifurcated from a common ancestor to cope with the increasing diversity of pathogens and injuries."
Thiago Carvalho
boosted
Clarence Thomas Promises To Adopt Code Of Ethics For The Right Price
https://www.theonion.com/clarence-thomas-promises-to-adopt-code-of-ethics-for-th-1850409408
'We now provide compelling evidence that in hypoxic conditions, an autocrine IL-24/IL-24-receptor signaling/STAT3 loop is induced, which then sustains the HIF1α-mediated expression of epidermal IL-24. In turn, IL-24 acts in an autocrine and paracrine fashion to coordinate re-epithelialization, re-vascularization, dermal fibroblast proliferation, and collagen deposition to restore the damaged tissue to homeostasis.'
Liu, @mucida, Fuchs et al
“Older adults, in particular those with underlying health conditions, such as heart or lung disease or weakened immune systems, are at high risk for severe disease caused by RSV,” said Dr. Peter Marks, director of the FDA’s Center for Biologics Evaluation and Research, in a statement. “Today’s approval of the first RSV vaccine is an important public health achievement to prevent a disease which can be life-threatening and reflects the FDA’s continued commitment to facilitating the development of safe and effective vaccines for use in the United States.”
https://edition.cnn.com/2023/05/03/health/first-rsv-vaccine-approved/index.html
'Their work paved the way for companies such as GSK, Pfizer and Moderna to develop the RSV vaccines in the pipeline today. “This is my lifetime's work. It’s very gratifying to see this finally happening,” Graham says. “It’s a good day for RSV.”
I wrote about RSV vaccines in my #NatureMedicine column in February.
Very good news this week with the FDA approval of GSK's RSV vaccine for adults 60 and over - it's the first approved RSV vaccine.
https://edition.cnn.com/2023/05/03/health/first-rsv-vaccine-approved/index.html
Several other candidate RSV vaccines are at a late stage of development, including mRNA based vaccines. The next big thing to watch for are those seeking to protect newborns and infants by maternal immunisation.
#RSV #Vaccine #RespiratoryVirus #drugdevelopment #Pharma #Immunology
Thiago Carvalho
boosted
'GSDM (the gene encoding gasdermin) and GSDM-like genes are evolutionarily ancient and have been identified across a wide range of animal and nonanimal species, including fungi and bacteria.'
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002103
Thiago Carvalho
boosted
'A similar percentage of deaths from the same side effect followed in the clinical trial of Leqembi, an F.D.A.-approved Alzheimer’s drug from the company Eisai. A third drug, Aduhelm, was also approved by the F.D.A., but is rarely used because of concerns about its effectiveness and its high price. Brain swelling was reported in its clinical trial and deaths were reported in patients taking Aduhelm after it was approved.'
https://www.nytimes.com/2023/05/03/health/alzheimers-drug-eli-lilly-trial.html
From Oliver Sacks, "River of Consciousness".
#Books #Bookshelf #BookClub #consciousness #SciComm #readerlife #bookstodon
Thiago Carvalho
boosted
Post-doctoral position - Oligodendroglial cells - Moyon lab @inp @NeuroSarah
Looking for a postdoctoral fellow to join a new neuroscience lab
#ScienceJobs #job @inp_marseille
Marseille #France #PostdoctoralFellow
https://jobrxiv.org/job/institute-of-neurophysiopathology-27778-post-doctoral-position-oligodendroglial-cells-moyon-lab-inp/?feed_id=44672
Thiago Carvalho
boosted
Remembering the one and only George Orson Welles (1915-85), the mercurial, Oscar / Grammy-winning film, radio and theatre actor, writer, producer and director, born in Wisconsin on this day. Pictured here, with Edward G. Robinson and Loretta Young, in his third film as director, the stunning noir The Stranger (1946).
#OrsonWelles #Actor #Director #MercuryTheatre #GoldenEraHollywood #ClassicHollywood #FilmNoir #BornOnThisDay #BOTD #OTD #OnThisDay
Herd- or group-think in drug development:
"Large companies are the biggest contributors to this phenomenon, with an estimated 68% of the portfolios of the top 10 companies going after targets with a significant amount of herding. And one of the reasons mentioned for this is the increasing number of combination therapies (especially in oncology), where organizations want their own drug candidates in that mix, rather than relying on having their new drug dosed with somebody else’s."
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
