Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
'The EU is ready to agree that immediate open access to papers reporting publicly funded research should become the norm, without authors having to pay fees, and that the bloc should support non-profit scholarly publishing models.'
Thiago Carvalho
boosted
@biorxivpreprint The here proposed relevant link between an neoepitope-dependent equal recognition by CD4+ and CD8+ T cells and positive response to #immunotherapy should be easily tested for confirmation in clinical samples from #vaccination trials, e.g. in #melanoma or #headneckcancers patients...but why have those one-vaccine-for-all-patients trials not shown positive results: no CD4+/CD8+ induction? Or no good neoepitope? Both? Else? @cyrilpedia @CastlTrAstonDrs @rio_sugimura
'Similarly, the C.D.C.’s budget process is byzantine. It has about 160 individual budget lines, and little to no ability to move funds to where they are needed in a crisis. That is not how FEMA and the Department of Defense operate amid a crisis. Congress has the power to grant the C.D.C. the essential flexibility it requires, and it should.'
https://www.nytimes.com/2023/05/07/opinion/cdc-overhaul.html
'Arthur Bispo do Rosario, a former Marine Corps signalman, boxer, tram cleaner and domestic worker in Rio de Janeiro, had no interest in defining his extensive activities as art. His unusual embroidered garments and textiles, ingenious assemblages and use of language had a higher purpose: Bispo was Jesus Christ, according to angels who visited him the night of Dec. 22, 1938, and instructed him to record, or possibly replicate reality. Thus, the title of his first retrospective in the United States, at the Americas Society in Manhattan: “Bispo do Rosario: All Existing Materials on Earth.”
https://www.nytimes.com/2023/05/05/arts/design/bispo-do-rosario-brazilian-artist.html
'Many experts welcomed the Lilly data as an important step forward but cautioned that donanemab was not a cure and the full results of the trial have not yet been published and need to be closely studied.'
https://www.ft.com/content/b18aefc1-ccbc-442e-a23c-117f27826d71
Thiago Carvalho
boosted
Spindle in dividing cells,
single when it sleeps.
Bids goodbye in fusing cells,
so many secrets to reveal!
Our Opinion on the cilium-centrosome axis buzzing with activity during fate choice! Now @J_Cell_Sci
#cilia #centrosomes #centriolarsatellites #RNA
https://journals.biologists.com/jcs/article-abstract/136/9/jcs260454/308872/The-cilium-centrosome-axis-in-coupling-cell-cycle?redirectedFrom=fulltext
Thiago Carvalho
boosted
Protein Engineering for Thermostability through Deep Evolution | https://www.biorxiv.org/content/10.1101/2023.05.04.539497v1.full.pdf+html #proteomics
'Só em Portugal é que isto poderia acontecer. Há uma crise política que ameaça a continuidade do Governo, mas quem pode acabar por cair é o líder do principal partido da oposição.'
https://www.publico.pt/2023/05/08/opiniao/opiniao/marcha-funebre-montenegro-entrada-passos-2048785
Thiago Carvalho
boosted
@NicoleCRust It's great if people can do research and are great communicators. But it should not be assumed, or required, to be the case in my opinion. A lot of funders are just tossing in mandates for SciComm in grants that I think are very inappropriate. We discussed this a bit on the #EMBOPodcast with Maria Leptin & Fiona Watt (after min 24) https://www.embo.org/podcasts/i-learned-early-on-that-you-can-do-a-lot-with-a-small-amount-of-money/
Thiago Carvalho
boosted
The East River, by @madparreira
#Print #Printmaking #handmade #printmakingart #artgallery #artmastodon
Thiago Carvalho
boosted
@CastlTrAstonDrs Not only relevant for #breastcancer but also for #colorectalcancer and more...central not only to bone metabolism but also relevant for the immune system...so consider Vit D levels in #cancer patients, even if they are exposed to the sun daily... @cyrilpedia #immunology
Thiago Carvalho
boosted
@biorxivpreprint Modulation of immune surveillance occuring during metastatic progression is still a major issue in #cancer #Immunology...and a recurring "smoking gun" are #macrophages and other #myeloidcells ...also here in this experimental model that uncovered a TLR-NFκB myeloid inflammatory program which correlates with pre-metastatic #niche formation and reflects similar signatures of CD14+ 'activated' myeloid cells in the primary tumor @cyrilpedia
Thiago Carvalho
boosted
The sawfly Athalia bicolor—splendid http://www.inaturalist.org/observations/160368408
#iNaturalist #Hymenoptera #sawflies #entomology #insects #MacroPhotography
The East River, by @madparreira
#Print #Printmaking #handmade #printmakingart #artgallery #artmastodon
Thiago Carvalho
boosted
🏳️🌈🖖🏽
If thoughts and prayers did any good, all of mine would have seen Ted Cruz lose his job long ago.
Thiago Carvalho
boosted
@gpollara @cyrilpedia @mucida Is absolutely intriguing... maybe #monocytes are compartimentalized in a way that the differential IL-24 profile can associated... #immunology
Thiago Carvalho
boosted
@cyrilpedia @gpollara @mucida And it also may be the link between #interferons , IL-10 and IL-1 bringing innate and adaptive #immunity together ...and very precise to point out the epidermal vs dermal compartimentalization @gpollara
Thiago Carvalho
boosted
I wrote this little program to visualise biological tracking data from #microscopy. We used it a lot for sense checking and verifying a lot of our data, but sadly it won't make it into our next paper. Anyway, today I tidied it up a bit and will make it available with all the rest of the code for others to use.
Thiago Carvalho
boosted
This is an outstanding reply to, and analysis of that Pamela Paul column in the New York Times that began this way:
"A paper that says science should be impartial was rejected by major journals. You can’t make this up."
Dave Karpf, an academic, takes it apart. He also testifies as a particiant in the peer review system. Worth your time.
https://davekarpf.substack.com/p/pamela-paul-cancel-culture-grifters?utm_medium=ios
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
