Thiago Carvalho @cyrilpedia@qoto.org

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Thanks to all the work the organizers and speakers put into this, and see many of you in New Mexico later this month! https://www.evolutionmeetings.org/

[This ends my rapid set of posting on this; safe to unmute for now]

Chromatin-associated condensates dysregulation in mendelian disorders

Università di Trento

#EU-funded #PhD project to address the contribution of #chromatin #condensates to define of the #genome architecture and nuclear #mechanobiology

See the full job description on jobRxiv: https://jobrxiv.org/job/universita-di-trento-27778-chromatin-associated-condensa...
https://jobrxiv.org/job/universita-di-trento-27778-chromatin-associated-condensates-dysregulation-in-mendelian-disorders/?feed_id=47152

'The cGAS-STING pathway has long been recognized as playing a crucial role in immune surveillance and tumor suppression. Here, we show that when the pathway is activated in a cancer-cell-autonomous response manner, it confers drug resistance.'

https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(23)00141-1

“There was an exchange on Twitter a while back where someone said, ‘What is artificial intelligence?’ And someone else said, ‘A poor choice of words in 1954’,” he says. “And, you know, they’re right. I think that if we had chosen a different phrase for it, back in the ’50s, we might have avoided a lot of the confusion that we’re having now.”

So if he had to invent a term, what would it be? His answer is instant: applied statistics.'

https://www.ft.com/content/c1f6d948-3dde-405f-924c-09cc0dcf8c84

UK mental health charities handed sensitive data to Facebook for targeted ads

https://www.theguardian.com/society/2023/jun/03/uk-mental-health-charities-handed-sensitive-data-to-facebook-for-targeted-ads?CMP=Share_iOSApp_Other #fail #cybersecurity

mpwR: an R package for comparing performance of mass spectrometry-based proteomic workflows | https://academic.oup.com/bioinformatics/advance-article/doi/10.1093/bioinformatics/btad358/7189730?login=false #proteomics

Good for them:

"Thousands of early-career researchers at the US National Institutes of Health (NIH) have kickstarted the process to form a union. They are calling on the NIH — the world’s largest biomedical funder — to raise pay and improve benefits, as well as to bolster its policies and procedures against harassment and excessive workloads."

https://www.nature.com/articles/d41586-023-01845-w

'The essential problem is that human language is not just about saying what and where things are and which qualities they harbor, such as being green or tall. Language is about what happened, what’s different, what’s on the move. At its core, language is all about the action — to wit, the verbs.'

https://www.nytimes.com/2023/06/01/opinion/verbs-language-instruction.html?action=click&module=Well&pgtype=Homepage&section=Guest%20Essays

'All​ over Europe, the police made the mistake of assuming that the next revolutionary outbreak would be the work of a handful of trained conspirators. The explosion of almost spontaneous mass uprisings by ‘the people’ – the pattern of 1848 – took governments, liberal reformers and even Count Metternich, the supreme architect of Europe’s post-1815 order, by surprise'

https://www.lrb.co.uk/the-paper/v45/n11/neal-ascherson/kings-grew-pale

'This is also a broader issue. The UK’s share of global pharma R&D has dropped sharply since 2012, from 7.7 per cent to 4.2 per cent in 2020. Manufacturing has fallen since 2015, according to the Association of the British Pharmaceutical Industry, along with exports. '

https://www.ft.com/content/aed6c929-6eeb-4f6d-bce7-d36445fc5ebf

'Old and newly synthesized histones are asymmetrically distributed and inherited in Drosophila intestinal stem cell divisions. Disruption of asymmetric histone inheritance compromises stem cell differentiation, indicating a role in regulating cell fates in adult stem lineages in vivo.'

https://www.embopress.org/doi/full/10.15252/embr.202256404

The Map of Medicine: A Comprehensive Animation Shows How the Fields of Modern Medicine Fit Together

https://www.openculture.com/2023/06/the-map-of-medicine.html

Here are 22 persuasive communication devices that you should watch out for when writing a research article. https://elifesciences.org/articles/88654?utm_source=mastodon&utm_medium=social&utm_campaign=organic_features

Looking forward to this EMBO Workshop:

Enhanceropathies: Understanding Enhancer Function to Understand Human Disease

Marseille, 17-20 October, 2023

Register now:
https://meetings.embo.org/event/23-enhanceropathies