Thiago Carvalho @cyrilpedia@qoto.org

'Provision of Signal 2 from DCs to naïve T cells during priming is the second critical step [30], which usually takes the form of DC-expressed CD80 and CD86 interacting with CD28 on T cells. Consistent with this, Cd80−/−Cd86−/− mice have impaired CD8+ T cell responses after Ad5 immunization, but for reasons that remain to be elucidated Cd28−/− mice have a different phenotype: delayed but not fully impaired CD8+ T cell responses'
#Immunology #Vaccine

https://onlinelibrary.wiley.com/doi/10.1002/eji.202250022

'Intas provided America with a lot of frontline chemotherapy drugs—half of the country’s supply in some cases—that are used to treat more than a dozen types of cancer. When the disastrous inspection led the company to halt production, other manufacturers couldn’t make up the difference.'

https://www.theatlantic.com/health/archive/2023/06/cancer-drug-market-dysfunction-supply-shortage/674512/

#Introduction (just moved to new instance)

I am a cell biologist running a research group (@roylelab) focused on membrane traffic and cell division in human cells. My lab is in @Warwick_CMCB at #WarwickUni. My posts are mainly about #science and #CellBiology but also #music, #running and #cycling.

My previous handle was clathrin. For my data analysis alter-ego, follow @quantixed.

#Microscopy #ImageAnalysis #MembraneTraffic #Mitosis #OpenScience #RStats

#HappyBirthday to Isabelle (Yasmina) Adjani, one of the greatest living French actors, born in Paris #OnThisDay in 1955. Winner of an unprecedented five Cesar acting Awards, she was extraordinary as Stella in Polanski's #TheTenant (1976), Lucy Harker in Herzog's #NosferatuTheVampyre (1979) and the title role in #LaReineMargot (1994). Pictured here in one of modern horror's most astonishing performances, as Sam Neill's fracturing, adulterous wife in Andrzej Zulawski's #Possession (1981).

#BOTD

'A Matter of Survival: How the WGA Is Trying to Save Feature Screenwriters'

John August and Writers Guild leaders weigh in about the systemic exploitation of feature screenwriters (i.e. free work) and the contract proposals that would help them...and the whole film industry in the process.

Read: https://open.substack.com/pub/colehaddon/p/a-matter-of-survival-how-the-wga?r=1mimd1&utm_campaign=post&utm_medium=web

#WGAstrong #WGAstrike #WGA #screenwriting #screenwriter #film #movies #cinema

Two papers from Semantic Web Applications and Tools for Health Care and Life Sciences 2023 #SWAT4HCLS2023 @swat4hcls with Bgee inside:
• Towards predicting essential proteins via federated SPARQL queries https://ceur-ws.org/Vol-3415/paper-45.pdf
• Data in use for Alzheimer disease study: combining gene expression, orthology, bioresource and disease datasets https://ceur-ws.org/Vol-3415/paper-47.pdf
#SIB #SemanticWeb #bioinformatics #GeneExpression

Comparing Kenyon cells between sawflies (ancestral Hymenoptera) and honeybees:

"Evolutionary dynamics of mushroom body Kenyon cell types in hymenopteran brains from multi-functional type to functionally specialized types", Kuwabara et al. 2023 https://www.science.org/doi/10.1126/sciadv.add4201

"the functions in learning and memory of the ancestral KC type were heterogeneously inherited among the KC types in the honey bee."

#neuroscience #Hymenoptera #honeybees #bees #KenyonCells

Hey Mastodon users! This is my first post as I just opened my account migrating from @doctorpoe on twitter. I hope to find my old friends and make new ones among the mastodon conoscenti.

Groundbreaking ceremony for the new building of the Helmholtz Institute for Translational Oncology #HI-TRON in Mainz (Germany), providing a space for novel cutting-edge #immunotherapy development, #personalizedmedicines and #mRNAs as tools in #cancer #research @mainz_de @unimainz @helmholtz @hereon @dkfz
https://www.dkfz.de/de/presse/pressemitteilungen/2023/dkfz-pm-23-33a-HI-TRON-Mainz-ein-Helmholtz-Institut-des-DKFZ-erhaelt-neues-Gebaeude.php

You don't have to use Mastodon through an app!

Every server has its own website where you can log in and use all its features. The web interface is excellent, and it usually gets the latest features before the apps do.

Your server's website address will usually be the same as its name, for example the website for the server kind.social is at https://kind.social

The website works on both computers and phones. (If you're using the phone version, click # to see the search box.)

#FediTips

First U.S. malaria cases diagnosed in decades in Florida and Texas

https://apple.news/AAKEPbESNQ3O6MrncKtzIJg

Looking forward to a great day of talks at the Jacques Monod insect models for infection biology! Thanks to @eLife and all sponsors! #InsInf2023

Random selection from Pastel's #proteomics resources page http://www.pastelbioscience.co.uk/resources/databases.html - = - https://github.com/ByrumLab/ProteoViz | ProteoViz | analysis and visualization of Phosphoproteomics data sets

The trial is for idiopathic pulmonary fibrosis.

'The company said the drug, INS018_055, was the first entirely “AI-discovered and AI designed” drug to begin a phase 2 clinical trial and represented an important milestone for the industry.'
#drugdiscovery #drugdevelopment #artificialintelligence

https://www.ft.com/content/82071cf2-f0da-432b-b815-606d602871fc