"We Americans tend to think that freedom is a matter of things being cleared away, and that capitalism does that work for us. It is a trap to believe in this,” he writes. “Freedom is not an absence but a presence, a life in which we choose multiple commitments and realize combinations of them in the world.”
https://www.vanityfair.com/news/story/timothy-snyder-american-fascism-under-trump
'We now report that efferocytosis triggers an indoleamine 2,3-dioxygenase-1 (IDO1)-dependent tryptophan (Trp) metabolism pathway that promotes several key resolution processes, including the induction of pro-resolving proteins, such interleukin-10, and further enhancement of efferocytosis.'
#Immunology
https://www.nature.com/articles/s42255-024-01115-7?utm_source=dlvr.it&utm
Testing the hypothesis that "despite the rapid evolution of reproductive protein genes, the functional basis of metazoan male germ cell identity relies on an old, evolutionarily conserved genetic program that can provide relevant insight into spermatogenesis and human infertility."
"Captain Needa had meant well. He and those in his command on an Imperial Star Destroyer ship were pursuing the Millennium Falcon when it inexplicably disappeared. Taking sole responsibility, he said that he alone would apologize to Darth Vader."
https://www.nytimes.com/2024/09/16/movies/star-wars-actors.html
'Here, we chose to study how centrosome amplification influences the response to combined Carboplatin and Paclitaxel in the context of epithelial ovarian cancer, a disease with poor clinical outcome related to late diagnosis, and frequent relapse'
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002759
@cyrilpedia Interesting. KarXT truly does use a novel mechanism of action- and we've not had thatbin quite some time. Effect sizes in studies are okay but KarXT isn't a miracle cure for schizophrenia of course.
We'll see what its role will be in clinical prectice, but cautious optimism is warranted.
"Larger-than-life screen personalities are necessarily watchable. Some also prove mysteriously listenable. Lynch is among them, a member of the small pantheon of filmmakers whose mystique is partly indebted to the textures of their speech: the gorgeous intonations of Orson Welles, the reminiscing tones of Agnès Varda, the runaway-train enthusiasm of Quentin Tarantino."
https://www.nytimes.com/2024/09/17/magazine/david-lynch-voice.html
Development of a cell-permeable Biotin-HaloTag ligand to explore functional differences between protein variants across cellular generations https://www.biorxiv.org/content/10.1101/2024.09.18.613519v1?med=mas
'If approved by regulators at the US Food and Drug Administration later this month, the experimental drug, known as KarXT, a twice daily pill, will arguably be the first truly novel treatment for #schizophrenia in more than seven decades.'
https://www.ft.com/content/427d37df-e2e9-4b67-87be-29f2a258de00
Research Assistant in Plant Biology (Fixed Term)
https://botany.fyi/22xdjf
Applications are invited for a Research Assistant position in the research group of Dr Katharina Schiessl at the Sainsbury Laboratory Cambridge University. The Schiessl Group investigates plant organs of diverse forms and functions in the context of plant microbe-interactions.
#PlantSciJobs @plantscijobs
Differential translocation of bacteriophages across the intestinal barrier in health and Crohn's disease https://www.biorxiv.org/content/10.1101/2024.09.17.613249v1?med=mas
Substrate-specific regulation of mTORC1 activity by G protein-coupled receptors https://www.biorxiv.org/content/10.1101/2024.09.18.613687v1?med=mas
'Toda a história entre a JC Decaux e a Câmara Municipal de Lisboa resume o guião clássico de Moedas: quando uma coisa corre mal, começa por culpar o antecessor, mente para fugir das responsabilidades e, se é apanhado, enfia a casca de Calimero na cabeça, vitimizando-se e pessoalizando o debate, para fugir ao escrutínio.'
https://expresso.pt/opiniao/2024-09-19-a-honra-de-moedas-nao-aguenta-as-mentiras-de-moedas-208d0133
Plate by Madalena
madalenaparreira.com
#ceramicart #ceramic #ceramicart
#handmade #ceramics #artgallery #pottery
Musk fanboys who should know better.
Reflecting on a conversation about Elon Musk with someone in a leadership position at work. They'd read several puff pieces about him and were wittering on about what a visionary he was and how he was such an inspirational leader. This was post-Twitter takeover but pre-undeniable nuttiness. #Musk was quite a useful barometer back then to figure out a person's character. Now Musk fanboyship is just an instant red flag.
Postdocl Research Fellow (personalized med for diseases of gene regulation)
The University of British Columbia
Two full time Postdoctoral Research Fellow positions in the de Boer lab (https://deboer.bme.ubc.ca/) at the University of British Columbia SBME.
See the full job description on jobRxiv: https://jobrxiv.org/job/the-university-of-...
https://jobrxiv.org/job/the-university-of-british-columbia-27778-postdocl-research-fellow-personalized-med-for-diseases-of-gene-regulation/?feed_id=82718
New Episode of the ReproducibiliTea Podcast!
Queen Saikia and @will_ngiam are joined by @JACoates from @ASAPbio to discuss how preprints and preprint review can accelerate science!
https://soundcloud.com/reproducibilitea/s4e2-preprint-review-with-jonny-coates-from-asapbio
Boundaries exist for a reason. You don’t have to reply to a work email or Slack message as soon as you see it.
After-hours communication depletes employees’ mental and emotional reserves.
https://theconversation.com/responding-to-work-emails-after-hours-contributes-to-burnout-hostility-229461
#work #stress #worklifebalance
"Olhando para trás, reconheço que posso ter sido injusta – não contemplei a possibilidade de que, ao falar aos jornalistas, Carlos Moedas não fizesse ideia do assunto, preferindo inventar uma resposta."
https://www.publico.pt/2024/09/18/opiniao/opiniao/mentiu-carlos-moedas-2104559
@cOAlitionS_OA is seeking comments on the new “How Equitable Is It?” framework for evaluating #ScholComm models.
https://www.coalition-s.org/new-tool-to-assess-equity-in-scholarly-communication-models/
The framework itself
https://coalitions.typeform.com/Equity-Tool?typeform-source=www.coalition-s.org
The framework comes from the "moving away from #APCs" working group led by cOAlition S, @jisc, and @PLOS.
https://www.coalition-s.org/moving-away-from-apcs/
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com