Johannes W. Dietrich @drjwdietrich@qoto.org

Sadly, John Midgley, a pioneer in #thyroid diagnostics and co-author of multiple papers by our group, passed away. Read Rudolf Hoermann's obituary at The Guardian:

https://www.theguardian.com/society/2024/apr/02/john-midgley-obituary

Our newest paper has been published. Based on machine learning with k-medoids #clustering we identified three different signatures of #thyroid #homeostasis that predict the prognosis of patients with #Takotsubo syndrome.

https://pubmed.ncbi.nlm.nih.gov/38502972/
https://doi.org/10.1016/j.ebiom.2024.105063

Therefore, the non-increased and, in many cases, even reduced beta cell function in metabolic syndrome may not mirror an "either-or" question but be part of continuous evolution. It may be a source of prediabetes and diabetes but also prevent insulinoma.

https://pubmed.ncbi.nlm.nih.gov/38169110/

The answer to this question may be in glucose toxicity leading to a biphasic response, thereby preventing neoplastic effects of dynamical compensation by mutant takeover.

https://pubmed.ncbi.nlm.nih.gov/28652282/

What is the primary event in the pathogenesis of type 2
#diabetes – dysfunction of pancreatic beta cells or hypersecretion of #insulin? This question is still unsolved and may represent a chicken-and-egg problem.

https://pubmed.ncbi.nlm.nih.gov/32894311/

Simulation des Modells des #Insulin-#Glukose-#Regelkreis​es nach Bolie auf einem #Analogrechner (THE ANALOG THING)

Simulating Bolie's model of insulin-glucose homeostasis with an analog computer (THE ANALOG THING) #theanalogthing

Early diagnosis of #diabetes continues to be a challenge. Recently, we developed a disposition index of insulin-glucose #homeostasis from fasting blood samples. The new parameter is not only less expensive but perhaps even better than established measures. https://doi.org/10.1111/1753-0407.13525

#Thyroid's secretory (#SPINA_GT) is higher in borderline personality disorder (#BPD) compared to controls. Is this a result of dynamical compensation or from sympathetic innervation of the thyroid gland? https://doi.org/10.3390/jcm12216702

#Thyroid hormones profoundly affect the heart. This also applies to chronic stress and type 2 allostatic load, where they relay signals from the brain to the heart. Our newest study observed an elevated thyroid output in borderline personality disorder. https://doi.org/10.3390/jcm12216702

2. Tag der #Diabetestechnologie: Vielfältiges Programm am Patiententag u. a. mit Dorothee Linnenbrink (aidhere) zu #Zanadio, den DiaEngeln und Antonia Vering aus unserem Team.

http://www.endokrinologie.org/tdt_2.html

2. Tag der Diabetestechnologie
20. und 21. Oktober 2023, St. Josef-Hospital Bochum

Zertifiziert mit 4 CME-Punkten (Ärztekammer Westfalen-Lippe @aekwl_kom) bzw. 7 Punkten (VDBD)

http://www.endokrinologie.org/tdt_2.html

Zum 2. Tag der #Diabetestechnologie lädt das Katholische Klinikum #Bochum am Freitag und Samstag ins Hörsaalzentrum des St. Josef-Hospital ein. Eine Anmeldung nicht erforderlich. #kkb #katholischesklinikumbochum #diabetes http://www.endokrinologie.org/tdt_2.html

1. Endokrinologische Abendsprechstunde im Hörsaalzentrum des St. Josef-Hospitals „Up-to-date #Schilddrüse 2023". Die Veranstaltung richtet sich an Patienten, Hausärzte, Angehörige und Interessierte. Eine Anmeldung ist nicht erforderlich. #Endokrinologie https://www.klinikum-bochum.de/medien/termine/details/1-endokrinologische-abendsprechstunde-up-to-date-schilddruese-2023.html