Johannes W. Dietrich @drjwdietrich@qoto.org

#Metformin is a useful antidiabetic substance, but also an endocrine disruptor. A recent study shows that it reduces the set point of #thyroid homeostasis, but this effect is mitigated by #vitamin_D deficiency.

https://pubmed.ncbi.nlm.nih.gov/39204438/
https://doi.org/10.3390/pharmaceutics16081093

Should we, therefore, classify #syndrome_T as a psychosomatic disease? This would be premature and probably wrong. We found signs of sensorimotor and autonomic #neuropathy that depend on autoimmunity and #thyroid's secretory capacity (#SPINA_GT).

Our newest paper provides new insights into the conundrum of #syndrome_T / #sorshot. #Anxiety and #depression are significantly more common in autoimmune #thyroiditis compared to healthy controls.

#thyroid #qol

https://doi.org/10.1038/s41598-024-63158-w

Sadly, John Midgley, a pioneer in #thyroid diagnostics and co-author of multiple papers by our group, passed away. Read Rudolf Hoermann's obituary at The Guardian:

https://www.theguardian.com/society/2024/apr/02/john-midgley-obituary

Our newest paper has been published. Based on machine learning with k-medoids #clustering we identified three different signatures of #thyroid #homeostasis that predict the prognosis of patients with #Takotsubo syndrome.

https://pubmed.ncbi.nlm.nih.gov/38502972/
https://doi.org/10.1016/j.ebiom.2024.105063

#Thyroid's secretory (#SPINA_GT) is higher in borderline personality disorder (#BPD) compared to controls. Is this a result of dynamical compensation or from sympathetic innervation of the thyroid gland? https://doi.org/10.3390/jcm12216702

#Thyroid hormones profoundly affect the heart. This also applies to chronic stress and type 2 allostatic load, where they relay signals from the brain to the heart. Our newest study observed an elevated thyroid output in borderline personality disorder. https://doi.org/10.3390/jcm12216702

Does impaired transport of #thyroid hormones into the central nervous system contribute to #syndrome_T / #SORSHOT? A recent study observed CSF/serum FT4 ratio to be associated with #QoL in treated #hypothyroidism. https://doi.org/10.1111/jne.13272

Recommended interview with Rudolf Hoermann on #thyroid #homeostasis and syndrome T: https://endocrinenews.endocrine.org/a-second-opinion/

Systems biology of #thyroid_homeostasis: Relational stability of two intertwined feedback loops protects #FT3 concentration despite variations in #thyroid's secretory capacity. https://doi.org/10.1177/20420188231158163

The Allan-Herndon-Dudley syndrome is a rare #thyroid disease caused by #MCT8 mutation, leading to severe consequences. Many aspects of its metabolic signature are poorly understood. In our newest paper, we present a theory that may provide new insights. https://pubmed.ncbi.nlm.nih.gov/36568087/

Our book "#Thyroid Hormones and Cardiac #Arrhythmia", including the articles from our Research Topic at Frontiers, is ready. Get your own free copy from http://dx.doi.org/10.3389/978-2-83250-253-2