Johannes W. Dietrich @drjwdietrich@qoto.org
- Sektion DES / Klinik
- http://www.endokrinologie.org
PD Dr. med. Johannes Dietrich, endocrinologist, head of the diabetes, endocrinology and metabolism section of #KKB @RUBMedizin. Views are my own.
Joined Nov 2022
Johannes W. Dietrich
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#SPINA_GT, #SPINA_GD and Jostel's TSH index (#JTI or #TSHI) are predictors of survival in patients with #Takotsubo syndrome (#stress #cardiomyopathy), as recently demonstrated in the international GEIST registry.
https://pubmed.ncbi.nlm.nih.gov/38502972/
https://doi.org/10.1016/j.ebiom.2024.105063
Our newest paper has been published. Based on machine learning with k-medoids #clustering we identified three different signatures of #thyroid #homeostasis that predict the prognosis of patients with #Takotsubo syndrome.
https://pubmed.ncbi.nlm.nih.gov/38502972/
https://doi.org/10.1016/j.ebiom.2024.105063
Therefore, the non-increased and, in many cases, even reduced beta cell function in metabolic syndrome may not mirror an "either-or" question but be part of continuous evolution. It may be a source of prediabetes and diabetes but also prevent insulinoma.
The answer to this question may be in glucose toxicity leading to a biphasic response, thereby preventing neoplastic effects of dynamical compensation by mutant takeover.
Simulation des Modells des #Insulin-#Glukose-#Regelkreises nach Bolie auf einem #Analogrechner (THE ANALOG THING)
Simulating Bolie's model of insulin-glucose homeostasis with an analog computer (THE ANALOG THING) #theanalogthing
Johannes W. Dietrich
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Howard Page Clark, author of many books on programming with #Pascal, #ObjectPascal and the #Lazarus_IDE passed away. R. I. P. https://www.blaisepascalmagazine.eu
Johannes W. Dietrich
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The Apple Macintosh has turned 40. Originally, it was a #Pascal machine, and #ObjectPascal has been developed to evolve its revolutionary operating system.
Johannes W. Dietrich
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A novel method for early detection and #endotyping of #Diabetes mellitus relies on software written in #ObjectPascal.
Today, this innovative approach is covered by all major press agencies and news channels all over the globe.
Johannes W. Dietrich
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#SPINA_Carb has high discriminatory power for the distinction between #diabetes and normal glucose homeostasis. SPINA-GBeta is better than HOMA-Beta, SPINA-GR is better than HOMA-IR and QUICKI, but SPINA-DI is best, being even more powerful than ivGTT. https://pubmed.ncbi.nlm.nih.gov/38169110/
Johannes W. Dietrich
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Recently, computer simulations with #SimulaBeta played a key role in the development of the fasting-based disposition index SPINA-DI, a substantially improved method to assess the function of the #insulin-#glucose feedback loop and for early diagnosis of #diabetes mellitus. https://doi.org/10.1111/1753-0407.13525
Early diagnosis of #diabetes continues to be a challenge. Recently, we developed a disposition index of insulin-glucose #homeostasis from fasting blood samples. The new parameter is not only less expensive but perhaps even better than established measures. https://doi.org/10.1111/1753-0407.13525
Johannes W. Dietrich
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Total step-up #deiodinase activity (#SPINA_GD) is upregulated in metabolic syndrome, as demonstrated by a strong correlation to the triglyceride-glucose index. https://pubmed.ncbi.nlm.nih.gov/37946276/ https://doi.org/10.1186/s40001-023-01501-z
#Thyroid's secretory (#SPINA_GT) is higher in borderline personality disorder (#BPD) compared to controls. Is this a result of dynamical compensation or from sympathetic innervation of the thyroid gland? https://doi.org/10.3390/jcm12216702
#Thyroid hormones profoundly affect the heart. This also applies to chronic stress and type 2 allostatic load, where they relay signals from the brain to the heart. Our newest study observed an elevated thyroid output in borderline personality disorder. https://doi.org/10.3390/jcm12216702
2. Tag der #Diabetestechnologie: Vielfältiges Programm am Patiententag u. a. mit Dorothee Linnenbrink (aidhere) zu #Zanadio, den DiaEngeln und Antonia Vering aus unserem Team.
2. Tag der Diabetestechnologie
20. und 21. Oktober 2023, St. Josef-Hospital Bochum
Zertifiziert mit 4 CME-Punkten (Ärztekammer Westfalen-Lippe @aekwl_kom) bzw. 7 Punkten (VDBD)
Zum 2. Tag der #Diabetestechnologie lädt das Katholische Klinikum #Bochum am Freitag und Samstag ins Hörsaalzentrum des St. Josef-Hospital ein. Eine Anmeldung nicht erforderlich. #kkb #katholischesklinikumbochum #diabetes http://www.endokrinologie.org/tdt_2.html
1. Endokrinologische Abendsprechstunde im Hörsaalzentrum des St. Josef-Hospitals „Up-to-date #Schilddrüse 2023". Die Veranstaltung richtet sich an Patienten, Hausärzte, Angehörige und Interessierte. Eine Anmeldung ist nicht erforderlich. #Endokrinologie https://www.klinikum-bochum.de/medien/termine/details/1-endokrinologische-abendsprechstunde-up-to-date-schilddruese-2023.html
Johannes W. Dietrich
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#Nickel is a toxic metal and an important endocrine disruptor. Recent research shows that exposure to nickel impairs #thyroid's secretory capacity (#SPINA_GT). https://pubmed.ncbi.nlm.nih.gov/37800147/ https://doi.org/10.3389/fendo.2023.1145153
- Sektion DES / Klinik
- http://www.endokrinologie.org
PD Dr. med. Johannes Dietrich, endocrinologist, head of the diabetes, endocrinology and metabolism section of #KKB @RUBMedizin. Views are my own.
Joined Nov 2022
