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DaveFinlayTCD

RT @RafaJArguello
📢🙏 share and help us to find a motivated PhD candidate for an 🤯🤓🤩 opportunity at @CancerImmunoAMU

🧪🧠 Exciting call in ! to advance research using innovative single-cell metabolomic profiling! @SCENITHmetab

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DaveFinlayTCD

An interesting new double act!!

immunotherapies engage to eliminate tumor antigen escape variants

doi.org/10.1016/j.cell.2023.03

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DaveFinlayTCD

RT @newscientist
Many people with obesity regain weight lost through diet and exercise programmes, but the health benefits remained even years later newscientist.com/article/23664

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DaveFinlayTCD

I never thought I would be a nerd, but here we are 🤷‍♂️🤣. Gonna enjoy reading doing of these articles.
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RT @CellPressNews
'The new @Molecular_Cell special issue focuses on the . The review articles in this issue focus on the diverse cellular processes involving mitochondria and the approaches used to study them. Take a look. hubs.li/Q01J2qN20
twitter.com/CellPressNews/stat

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DaveFinlayTCD

RT @Morganti_Lab
Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration | Nature Metabolism nature.com/articles/s42255-023

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DaveFinlayTCD

Striking changes in tumour infiltrating NK cell surface topology, observed using a range of Electron microscopy techniques - worth a look.
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RT @NK_papers
Tumors evade immune cytotoxicity by altering the surface topology of NK cells by Xiaohu Zheng ift.tt/Fj7tYX8
twitter.com/NK_papers/status/1

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DaveFinlayTCD boosted
Tomás Ryan

RT @RyanLabTCD
New Ryan Lab preprint on the adaptive properties of forgetting - featuring the PhD research of Livia Autore, with @jamesoleary & @Clrar.

Adaptive Expression of Engrams by Retroactive Interference biorxiv.org/content/10.1101/20

Adaptive Expression of Engrams by Retroactive Interference

Long-term memories are stored as stable configurations of neuronal ensembles, termed engrams. While investigation of engram cell properties and functionality in memory recall has been extensive, less is known about how engram cells are affected by forgetting. We describe a form of interference-based forgetting using an object memory behavioral paradigm. By using activity-dependent cell labelling, we show that although retroactive interference results in decreased engram cell reactivation during recall trials, optogenetic stimulation of the labelled engram cells is sufficient to induce memory retrieval. Forgotten engrams may also be reinstated via the presentation of similar or related environmental information. Furthermore, we demonstrate that engram activity is necessary for interference to occur. Taken together, these findings indicate that retroactive interference modulates engram expression in a manner that is both reversible and updatable. Retroactive inference may constitute a form of adaptive forgetting, where in everyday life new perceptual and environmental inputs modulate the natural forgetting process. ### Competing Interest Statement The authors have declared no competing interest.

www.biorxiv.org
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DaveFinlayTCD

RT @biorxiv_cellbio
Hexokinase 1 forms rings that constrict mitochondria during energy stress biorxiv.org/cgi/content/short/

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DaveFinlayTCD

Mitochondrial damage activates the NLRP10 inflammasome
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RT @IIIBonn
We are super excited to share the newest publication from the Latz Lab @IIIBonn in @NatImmunol 🔥🎉

nature.com/articles/s41590-023

A great collaboration with Franklin Zhong and @FISchmidtLab

Summary below, from twitterless 1st author Tom... 1/n
twitter.com/IIIBonn/status/163

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DaveFinlayTCD

RT @TCDPharmacy
We are hiring! We have four fantastic funded open for applications here in the School of Pharmacy. Full information here pharmacy.tcd.ie/research/Panoz
Please retweet and share 😊

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DaveFinlayTCD

RT @RyanLab_MBU
Monocarboxylate transporters facilitate succinate uptake into brown adipocytes
Nice work @AnitaReddy1, @echouchani, @evanna_mills and team! Great to see the mechanism of uptake solved!
biorxiv.org/content/10.1101/20

Monocarboxylate transporters facilitate succinate uptake into brown adipocytes

Uptake of circulating succinate by brown adipose tissue (BAT) and beige fat elevates whole body energy expenditure, counteracts obesity, and antagonizes systemic tissue inflammation in mice. The plasma membrane transporters that facilitate succinate uptake in these adipocytes remain undefined. Here we elucidate a mechanism underlying succinate import into BAT via monocarboxylate transporters (MCTs). We show that succinate transport is strongly dependent on the proportion of it present in the monocarboxylate form. MCTs facilitate monocarboxylate succinate uptake, which is promoted by alkalinization of the cytosol driven by adrenoreceptor stimulation. In brown adipocytes, we show that MCT1 primarily facilitates succinate import, however other members of the MCT family can partially compensate and fulfill this role in the absence of MCT1. In mice, we show that acute pharmacological inhibition of MCT1 and 2 decreases succinate uptake into BAT. Conversely, congenital genetic depletion of MCT1 alone has little effect on BAT succinate uptake, indicative of additional transport mechanisms with high capacity in vivo . In sum, we define a mechanism of succinate uptake in BAT that underlies its protective activity in mouse models of metabolic disease. ### Competing Interest Statement E.T.C. is a founder, board member and equity holder in Matchpoint Therapeutics and Aevum Therapeutics.

www.biorxiv.org
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DaveFinlayTCD

M1 macrophage - fragmented mitochondria - glycolytic

M2 macrophage - elongated mitochondria - FAO

Also opposite to correlation described by Ngo et al. in non immune cells:
doi.org/10.15252/embj.20221119

🤨 something different it’s going on in

Any other examples?

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DaveFinlayTCD

Effector CD8 T cells - fragmented mitochondria but glycolytic

Memory CD8 T cells - elongated mitochondria but use FAO and OXPHOS

Opposite way around to mechanism described by NGO et al.

🤔 Food for thought..

Other Immunometabolism examples? Reply..

(From Erika Pearce’s lab)

Show thread
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DaveFinlayTCD

Oooooo, what’s that…mitochondria morphology controls Fatty acid oxidation (FAO). 🤔

Fragmented - CPT1 more active - ⬆️ FAO.

Elongated - CPT1 more sensitive to inhibition - ⬇️ FAO

Does this fit with what we know about Immunometabolism? 🤔🤨🧐

doi.org/10.15252/embj.20221119

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DaveFinlayTCD

RT @FrezzaLab
If you are looking for a post doc in immunemetabolism, look no further. Dylan is an exceptional scientist! 👇👇🔥🔥 twitter.com/RyanLab_MBU/status

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DaveFinlayTCD

RT @laoneill111
Great opportunity to join Dylan Ryan’s lab - you won’t work with a better PI in a superb area with huge potential. twitter.com/ryanlab_mbu/status

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DaveFinlayTCD

Amazing opportunity for anyone looking for a postdoc. , and the chance to work with the immensely talented Dylan Ryan
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RT @RyanLab_MBU
🚨To and lovers everywhere🚨

There is an opportunity to join the newly minted Ryan group @MRC_MBU @Cambridge_Uni as a postdoctoral research associate.

Please check out the advert below and I appreciate any shares⬇️⬇️⬇️

https://www.nature…
twitter.com/RyanLab_MBU/status

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DaveFinlayTCD

RT @OxfordDiplomat
An absolutely stunning video from Ireland’s Department of Foreign Affairs and Trade, celebrating not just St Patrick's Day, but a Century of Peace building, 100 years after our independence. Happy
one and all ☘️ 🇮🇪

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DaveFinlayTCD

RT @LabWaggoner
Novel mouse models based on intersectional genetics to identify and characterize pDCs @NatImmunol @DalodCiml
nature.com/articles/s41590-023

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DaveFinlayTCD

RT @LabWaggoner
Protein posttranslational modifications can break tolerance to the self-proteome: metabolite-induced cysteine carboxyethylation generates neoantigens that may fuel autoimmunity @ScienceMagazine
science.org/doi/10.1126/scienc
news: science.org/doi/10.1126/scienc

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