Mitochondrial damage activates the NLRP10 inflammasome
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RT @IIIBonn
We are super excited to share the newest publication from the Latz Lab @IIIBonn in @NatImmunol 🔥🎉
https://www.nature.com/articles/s41590-023-01451-y
A great collaboration with Franklin Zhong and @FISchmidtLab
Summary below, from twitterless 1st author Tom... 1/n
https://twitter.com/IIIBonn/status/1637848269681205248
RT @TCDPharmacy
We are hiring! We have four fantastic funded #PhDpositions open for applications here in the School of Pharmacy. Full information here https://pharmacy.tcd.ie/research/Panoz_PhD.php
Please retweet and share 😊
RT @RyanLab_MBU
Monocarboxylate transporters facilitate succinate uptake into brown adipocytes
Nice work @AnitaReddy1, @echouchani, @evanna_mills and team! Great to see the mechanism of uptake solved!
https://www.biorxiv.org/content/10.1101/2023.03.01.530625v1
M1 macrophage - fragmented mitochondria - glycolytic
M2 macrophage - elongated mitochondria - FAO
Also opposite to correlation described by Ngo et al. in non immune cells:
https://doi.org/10.15252/embj.2022111901
🤨 something different it’s going on in #Immunometabolism
Any other examples?
Effector CD8 T cells - fragmented mitochondria but glycolytic
Memory CD8 T cells - elongated mitochondria but use FAO and OXPHOS
Opposite way around to mechanism described by NGO et al.
🤔 Food for thought..
Other Immunometabolism examples? Reply..
(From Erika Pearce’s lab)
Oooooo, what’s that…mitochondria morphology controls Fatty acid oxidation (FAO). 🤔
Fragmented - CPT1 more active - ⬆️ FAO.
Elongated - CPT1 more sensitive to inhibition - ⬇️ FAO
Does this fit with what we know about Immunometabolism? 🤔🤨🧐
RT @FrezzaLab
If you are looking for a post doc in immunemetabolism, look no further. Dylan is an exceptional scientist! 👇👇🔥🔥 https://twitter.com/RyanLab_MBU/status/1636713209913569281
RT @laoneill111
Great opportunity to join Dylan Ryan’s lab - you won’t work with a better PI in a superb area with huge potential. https://twitter.com/ryanlab_mbu/status/1636713209913569281
Amazing opportunity for anyone looking for a postdoc. #immunometabolism, #mitochondria and the chance to work with the immensely talented Dylan Ryan
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RT @RyanLab_MBU
🚨To #immunometabolism and #mitochondria lovers everywhere🚨
There is an opportunity to join the newly minted Ryan group @MRC_MBU @Cambridge_Uni as a postdoctoral research associate.
Please check out the advert below and I appreciate any shares⬇️⬇️⬇️
https://www.nature…
https://twitter.com/RyanLab_MBU/status/1636713209913569281
RT @OxfordDiplomat
An absolutely stunning video from Ireland’s Department of Foreign Affairs and Trade, celebrating not just St Patrick's Day, but a Century of Peace building, 100 years after our independence. Happy #StPatricksDay
one and all ☘️ #GlobalIreland 🇮🇪
RT @LabWaggoner
Novel mouse models based on intersectional genetics to identify and characterize pDCs @NatImmunol #valente @DalodCiml #Tomasello
https://www.nature.com/articles/s41590-023-01454-9
RT @LabWaggoner
Protein posttranslational modifications can break tolerance to the self-proteome: metabolite-induced cysteine carboxyethylation generates neoantigens that may fuel autoimmunity @ScienceMagazine
https://www.science.org/doi/10.1126/science.abg2482
news: https://www.science.org/doi/10.1126/science.adg3925
RT @GarethBrady6
Paper just out from the lab on a new mechanism of innate immune inhibition by the human-specific poxvirus Molluscum Contagiosum Virus funded by @SFI Frontiers. Congrats @ThomasPhelan2 who just handed in his PhD thesis on this work. @TCDTMI @TrinityMed1 https://journals.asm.org/doi/abs/10.1128/jvi.00108-23?af=R
RT @FrezzaLab
Congrats to the @echouchani
and team! another milestone
https://www.nature.com/articles/s41586-023-05939-3
RT @FrezzaLab
whoa, what a day... a milestone for mitochondrial biology in cancer from the Shackelford lab! https://www.nature.com/articles/s41586-023-05793-3
RT @LallyLangford
This is dynamite from Kaveh Solhekol on Sky Sports News. Absolutely nails it. He has the Tories and BBC on toast. Well done!! 👏 Take 2 mins and watch👇#garylineker #ImWithGary #MOTD #ToryFascists
RT @JustMissEmma
Dear @GaryLineker
You were one of the first people to donate towards my fundraising for neurorehab, so In light of the shit show that’s unfolding right now, I thought I’d pick this moment to share that because of you and so many other incredible people here, I took my first… https://twitter.com/i/web/status/1634262665445908488
RT @Rainmaker1973
The theory of quaternions was born when a sudden thought came to William Rowan Hamilton as he was walking with his wife along the Royal Canal in Dublin, Ireland. It was the fundamental formula:
i² = j² = k² = ikj = -1
[read more: https://buff.ly/3pndnxN]
We are an Immunometabolism research group that studies how nutrients and metabolism affect immune cell function at #TrinityCollegeDublin👨🔬 Love #NK_cells, #Dendritic_cells and #T_cells but can be easily convinced to talk at length about metabolism in any immune cell 😄. Twitter handle @DavidFinlayTCD