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Mitochondrial damage activates the NLRP10 inflammasome
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RT @IIIBonn
We are super excited to share the newest publication from the Latz Lab @IIIBonn in @NatImmunol 🔥🎉

nature.com/articles/s41590-023

A great collaboration with Franklin Zhong and @FISchmidtLab

Summary below, from twitterless 1st author Tom... 1/n
twitter.com/IIIBonn/status/163

RT @RyanLab_MBU
Monocarboxylate transporters facilitate succinate uptake into brown adipocytes
Nice work @AnitaReddy1, @echouchani, @evanna_mills and team! Great to see the mechanism of uptake solved!
biorxiv.org/content/10.1101/20

Monocarboxylate transporters facilitate succinate uptake into brown adipocytes

Uptake of circulating succinate by brown adipose tissue (BAT) and beige fat elevates whole body energy expenditure, counteracts obesity, and antagonizes systemic tissue inflammation in mice. The plasma membrane transporters that facilitate succinate uptake in these adipocytes remain undefined. Here we elucidate a mechanism underlying succinate import into BAT via monocarboxylate transporters (MCTs). We show that succinate transport is strongly dependent on the proportion of it present in the monocarboxylate form. MCTs facilitate monocarboxylate succinate uptake, which is promoted by alkalinization of the cytosol driven by adrenoreceptor stimulation. In brown adipocytes, we show that MCT1 primarily facilitates succinate import, however other members of the MCT family can partially compensate and fulfill this role in the absence of MCT1. In mice, we show that acute pharmacological inhibition of MCT1 and 2 decreases succinate uptake into BAT. Conversely, congenital genetic depletion of MCT1 alone has little effect on BAT succinate uptake, indicative of additional transport mechanisms with high capacity in vivo . In sum, we define a mechanism of succinate uptake in BAT that underlies its protective activity in mouse models of metabolic disease. ### Competing Interest Statement E.T.C. is a founder, board member and equity holder in Matchpoint Therapeutics and Aevum Therapeutics.

www.biorxiv.org

M1 macrophage - fragmented mitochondria - glycolytic

M2 macrophage - elongated mitochondria - FAO

Also opposite to correlation described by Ngo et al. in non immune cells:
doi.org/10.15252/embj.20221119

🤨 something different it’s going on in

Any other examples?

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Effector CD8 T cells - fragmented mitochondria but glycolytic

Memory CD8 T cells - elongated mitochondria but use FAO and OXPHOS

Opposite way around to mechanism described by NGO et al.

🤔 Food for thought..

Other Immunometabolism examples? Reply..

(From Erika Pearce’s lab)

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Oooooo, what’s that…mitochondria morphology controls Fatty acid oxidation (FAO). 🤔

Fragmented - CPT1 more active - ⬆️ FAO.

Elongated - CPT1 more sensitive to inhibition - ⬇️ FAO

Does this fit with what we know about Immunometabolism? 🤔🤨🧐

doi.org/10.15252/embj.20221119

RT @FrezzaLab
If you are looking for a post doc in immunemetabolism, look no further. Dylan is an exceptional scientist! 👇👇🔥🔥 twitter.com/RyanLab_MBU/status

RT @laoneill111
Great opportunity to join Dylan Ryan’s lab - you won’t work with a better PI in a superb area with huge potential. twitter.com/ryanlab_mbu/status

Amazing opportunity for anyone looking for a postdoc. , and the chance to work with the immensely talented Dylan Ryan
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RT @RyanLab_MBU
🚨To and lovers everywhere🚨

There is an opportunity to join the newly minted Ryan group @MRC_MBU @Cambridge_Uni as a postdoctoral research associate.

Please check out the advert below and I appreciate any shares⬇️⬇️⬇️

https://www.nature…
twitter.com/RyanLab_MBU/status

RT @OxfordDiplomat
An absolutely stunning video from Ireland’s Department of Foreign Affairs and Trade, celebrating not just St Patrick's Day, but a Century of Peace building, 100 years after our independence. Happy
one and all ☘️ 🇮🇪

RT @LabWaggoner
Novel mouse models based on intersectional genetics to identify and characterize pDCs @NatImmunol @DalodCiml
nature.com/articles/s41590-023

RT @LabWaggoner
Protein posttranslational modifications can break tolerance to the self-proteome: metabolite-induced cysteine carboxyethylation generates neoantigens that may fuel autoimmunity @ScienceMagazine
science.org/doi/10.1126/scienc
news: science.org/doi/10.1126/scienc

RT @GarethBrady6
Paper just out from the lab on a new mechanism of innate immune inhibition by the human-specific poxvirus Molluscum Contagiosum Virus funded by @SFI Frontiers. Congrats @ThomasPhelan2 who just handed in his PhD thesis on this work. @TCDTMI @TrinityMed1 journals.asm.org/doi/abs/10.11

RT @FrezzaLab
whoa, what a day... a milestone for mitochondrial biology in cancer from the Shackelford lab! nature.com/articles/s41586-023

RT @LallyLangford
This is dynamite from Kaveh Solhekol on Sky Sports News. Absolutely nails it. He has the Tories and BBC on toast. Well done!! 👏 Take 2 mins and watch👇

RT @maitlis
This intro is brilliant - but the whole piece is so smart and so thoughtful too.

RT @JustMissEmma
Dear @GaryLineker
You were one of the first people to donate towards my fundraising for neurorehab, so In light of the shit show that’s unfolding right now, I thought I’d pick this moment to share that because of you and so many other incredible people here, I took my first… twitter.com/i/web/status/16342

RT @Rainmaker1973
The theory of quaternions was born when a sudden thought came to William Rowan Hamilton as he was walking with his wife along the Royal Canal in Dublin, Ireland. It was the fundamental formula:

i² = j² = k² = ikj = -1

[read more: buff.ly/3pndnxN]

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