Mitochondrial damage activates the NLRP10 inflammasome
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RT @IIIBonn
We are super excited to share the newest publication from the Latz Lab @IIIBonn in @NatImmunol
https://www.nature.com/articles/s41590-023-01451-y
A great collaboration with Franklin Zhong and @FISchmidtLab
Summary below, from twitterless 1st author Tom... 1/n
https://twitter.com/IIIBonn/status/1637848269681205248
RT @TCDPharmacy
We are hiring! We have four fantastic funded #PhDpositions open for applications here in the School of Pharmacy. Full information here https://pharmacy.tcd.ie/research/Panoz_PhD.php
Please retweet and share
RT @RyanLab_MBU
Monocarboxylate transporters facilitate succinate uptake into brown adipocytes
Nice work @AnitaReddy1, @echouchani, @evanna_mills and team! Great to see the mechanism of uptake solved!
https://www.biorxiv.org/content/10.1101/2023.03.01.530625v1
M1 macrophage - fragmented mitochondria - glycolytic
M2 macrophage - elongated mitochondria - FAO
Also opposite to correlation described by Ngo et al. in non immune cells:
https://doi.org/10.15252/embj.2022111901
something different it’s going on in #Immunometabolism
Any other examples?
Effector CD8 T cells - fragmented mitochondria but glycolytic
Memory CD8 T cells - elongated mitochondria but use FAO and OXPHOS
Opposite way around to mechanism described by NGO et al.
Food for thought..
Other Immunometabolism examples? Reply..
(From Erika Pearce’s lab)
Oooooo, what’s that…mitochondria morphology controls Fatty acid oxidation (FAO).
Fragmented - CPT1 more active - FAO.
Elongated - CPT1 more sensitive to inhibition - FAO
Does this fit with what we know about Immunometabolism?
RT @FrezzaLab
If you are looking for a post doc in immunemetabolism, look no further. Dylan is an exceptional scientist! https://twitter.com/RyanLab_MBU/status/1636713209913569281
RT @laoneill111
Great opportunity to join Dylan Ryan’s lab - you won’t work with a better PI in a superb area with huge potential. https://twitter.com/ryanlab_mbu/status/1636713209913569281
Amazing opportunity for anyone looking for a postdoc. #immunometabolism, #mitochondria and the chance to work with the immensely talented Dylan Ryan
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RT @RyanLab_MBUTo #immunometabolism and #mitochondria lovers everywhere
There is an opportunity to join the newly minted Ryan group @MRC_MBU @Cambridge_Uni as a postdoctoral research associate.
Please check out the advert below and I appreciate any shares
https://www.nature…
https://twitter.com/RyanLab_MBU/status/1636713209913569281
RT @OxfordDiplomat
An absolutely stunning video from Ireland’s Department of Foreign Affairs and Trade, celebrating not just St Patrick's Day, but a Century of Peace building, 100 years after our independence. Happy #StPatricksDay
one and all #GlobalIreland
RT @LabWaggoner
Novel mouse models based on intersectional genetics to identify and characterize pDCs @NatImmunol #valente @DalodCiml #Tomasello
https://www.nature.com/articles/s41590-023-01454-9
RT @LabWaggoner
Protein posttranslational modifications can break tolerance to the self-proteome: metabolite-induced cysteine carboxyethylation generates neoantigens that may fuel autoimmunity @ScienceMagazine
https://www.science.org/doi/10.1126/science.abg2482
news: https://www.science.org/doi/10.1126/science.adg3925
RT @GarethBrady6
Paper just out from the lab on a new mechanism of innate immune inhibition by the human-specific poxvirus Molluscum Contagiosum Virus funded by @SFI Frontiers. Congrats @ThomasPhelan2 who just handed in his PhD thesis on this work. @TCDTMI @TrinityMed1 https://journals.asm.org/doi/abs/10.1128/jvi.00108-23?af=R
RT @FrezzaLab
Congrats to the @echouchani
and team! another milestone
https://www.nature.com/articles/s41586-023-05939-3
RT @FrezzaLab
whoa, what a day... a milestone for mitochondrial biology in cancer from the Shackelford lab! https://www.nature.com/articles/s41586-023-05793-3
RT @LallyLangford
This is dynamite from Kaveh Solhekol on Sky Sports News. Absolutely nails it. He has the Tories and BBC on toast. Well done!! Take 2 mins and watch
#garylineker #ImWithGary #MOTD #ToryFascists
RT @JustMissEmma
Dear @GaryLineker
You were one of the first people to donate towards my fundraising for neurorehab, so In light of the shit show that’s unfolding right now, I thought I’d pick this moment to share that because of you and so many other incredible people here, I took my first… https://twitter.com/i/web/status/1634262665445908488
RT @Rainmaker1973
The theory of quaternions was born when a sudden thought came to William Rowan Hamilton as he was walking with his wife along the Royal Canal in Dublin, Ireland. It was the fundamental formula:
i² = j² = k² = ikj = -1
[read more: https://buff.ly/3pndnxN]
We are an Immunometabolism research group that studies how nutrients and metabolism affect immune cell function at #TrinityCollegeDublin
Love #NK_cells, #Dendritic_cells and #T_cells but can be easily convinced to talk at length about metabolism in any immune cell
. Twitter handle @DavidFinlayTCD