DaveFinlayTCD @finlayd@qoto.org
We are an Immunometabolism research group that studies how nutrients and metabolism affect immune cell function at #TrinityCollegeDublin👨🔬 Love #NK_cells, #Dendritic_cells and #T_cells but can be easily convinced to talk at length about metabolism in any immune cell 😄. Twitter handle @DavidFinlayTCD
Joined Nov 2022
RT @TCDPharmacy
Congratulations to all those awarded fellowship @tcddublin today and especially to two of our own- Professor Sakis Mantalaris and Professor Niamh O'Boyle! We are all so proud of you both! #celebrations #pharmacy #Trinitymonday
RT @DHSCgovuk
Vaccination is the best way to protect ourselves and our children against serious infectious diseases.
It's important that vaccines are given on time - but if you or your child have missed one, contact your GP to catch up.
#WorldImmunisationWeek #VaccinesWork
More 🔽
I’ve been thinking about using fermented foods to repopulate my gut microbiome (on lots of antibiotics lately)
Maybe not 😮🤯
‘antibiotic-resistant bacteria were isolated from approximately 90% of the retail kimchi and all artisan cheeses assessed in this pilot screening’
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RT @biorxivpreprint
Traditionally fermented foods still a critical avenue impacting host gut antibiotic resistome https://biorxiv.org/cgi/content/short/2023.…
https://twitter.com/biorxivpreprint/status/1650005836247252992
Don't you just LOVE when a paper comes out providing an explanation for a long term lab question 😀🎉 Mystery solved!!
This really nice paper just out in #PLOSpathogens
by @FirpoMason and @bryancmounce based at the Loyola University Chicago @LoyolaInDIRI. (a🧵)
Our Question?
RT @RyanLab_MBU
🚨Last weeks #immunometabolism discoveries🚨 @Bims_BiomedNews ⬇️⬇️⬇️
http://biomed.news/bims-imicid/2023-04-23
Highlights:
I) MYC-SLC7A5-glycolysis metabolic axis regulates MAIT cell proliferation & is impaired in obesity
II) Hypusination regulates SREBP2 translation & enterovirus infection
RT @UMassMetNet
Had a wonderful day with guest "Fluxing Star" Evanna Mills (sporting a MetNet T-shirt!) who's seminar on how metabolites function as signaling molecules was outstanding! Learn about Evanna and her amazing ability to hold a plank at the Metabolog - https://www.umassmed.edu/metnet/blog/2023/04/evanna-mills/
RT @FrezzaLab
The proliferation of human mucosal-associated invariant T cells requires a MYC-SLC7A5-glycolysis metabolic axis https://www.science.org/doi/10.1126/scisignal.abo2709#.ZEA7hSv8iyY.twitter
RT @AislingRehill
Delighted to share a pre print of my work looking at the intersection of inflammation, glycolysis and thrombosis. Thanks to all our collaborators for contributing to this exciting story! @rogerjspreston
@PrestonLab_RCSI @RCSIPharmBioMol @IrishCtrVascBio https://www.biorxiv.org/content/10.1101/2023.04.20.537683v1
CD8+ T cell activation in cancer comprises an initial activation phase in lymph nodes followed by effector differentiation within the tumor
>100 RNA binding proteins identified that bind to 3’UTR of cytokine mRNA (IFNg, TNF and IL2) in Human T cells.
#immunometabolism finding (Supl Tables 1 and 3)
GAPDH binding to cytokine 3’UTR in PMA/Ionomycin activated, but not untreated, Human T cells.
DaveFinlayTCD
boosted
Very pleased to see our paper is now in print:
https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00430-8
here we show how RNA binding proteins regulate the magnitude and timing of cytokine expression in human T cells. and how the identified RBPs act a different time points and through different mechansism. The wonder world of RNA...
#RNA #RBPs #Immunology #Tcells #cytokines #regulation #proteomics
RT @AndyHogan82
Delighted to see our latest paper out in @scisignal - led by @KediaMehta & Marta Pisarska with superstar collaborator @LindaVSinclair - we go deeper on #MAITcell metabolism and the impact of obesity - https://www.science.org/doi/10.1126/scisignal.abo2709
RT @NgordonNeil
@tcddublin research from Matt Campbell and Jeff O’Callaghan glaucoma gene therapy that can change peoples lives @TCD_Innovation @scienceirel @Entirl @KTIconnect https://www.science.org/doi/10.1126/sciadv.adf6537#.ZEK0ToaEtzw.linkedin
A great opportunity here to do a PhD working on immunometabolism during viral infection. @tcdTBSI @tcdbi @BiochemSocTCD
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RT @LittwitzSalomon
Are you looking for a PhD position in the field of virology and immunology as well as immunometabolism? Please apply here:
https://karriere.ume.de/job-finder/?get_job=9853
https://twitter.com/LittwitzSalomon/status/1649301781803941888
RT @MiriamMerad
Excited to share our new paper in @NatImmunol on how TREM2+ monocyte-derived macrophages in lung cancer reduce activity of natural killer cells that fight tumors. We provide potential dual targeting strategies to improve antitumor immunity. Read here: https://rdcu.be/damS8
RT @McLoughlin_Lab
Fantastic research on show today @tcdTBSI for our annual celebration of Postgraduate research @tcdbi Congratulations to Roisin Lynch from @EdLavellee lab this years winner of the Tipton medal for postgraduate research also Erika Stewart from @TJRyan_77 lab a worthy runner up.
RT @LindaVSinclair
So happy and proud to see this paper out now! Big collaborative effort - well done @KediaMehta @AndyHogan82
“The proliferation of human mucosal-associated invariant T cells requires a MYC-SLC7A5-glycolysis metabolic axis” https://www.science.org/doi/10.1126/scisignal.abo2709#.ZD8HaZ47ca8.twitter
This is why ye want to release those cytotoxic granules directly at a target cell! 🤷♂️
NK cell-derived extracellular granzyme B drives epithelial ulceration during HSV-2 genital infection
RT @immunotea
Brand new episode of ImmunoTea where we talk to @AonghusLavelle all about the different microbiomes and the immunology surrounding them. Get it here on Apple Podcasts https://podcasts.apple.com/ie/podcast/immunotea-your-immunology-podcast/id1663948139?i=1000609193034
We are an Immunometabolism research group that studies how nutrients and metabolism affect immune cell function at #TrinityCollegeDublin👨🔬 Love #NK_cells, #Dendritic_cells and #T_cells but can be easily convinced to talk at length about metabolism in any immune cell 😄. Twitter handle @DavidFinlayTCD
Joined Nov 2022
