DaveFinlayTCD @finlayd@qoto.org
We are an Immunometabolism research group that studies how nutrients and metabolism affect immune cell function at #TrinityCollegeDublin👨🔬 Love #NK_cells, #Dendritic_cells and #T_cells but can be easily convinced to talk at length about metabolism in any immune cell 😄. Twitter handle @DavidFinlayTCD
Joined Nov 2022
Key advance:
Generating an IDO-Gal3 fusion protein.
Gal3 binds to fly and in the extracellular matrix (ECM) of tissues, anchoring IDO in place at the site of inflammation - very clever IMHO. (2/5)
Harnessing anti-inflammatory potential of IDO.
Exciting new approach by @keselowsky, @GregHudalla using IDO therapeutically as an anti-inflammatory . (Short 🧵 1/5)
Suppression of local inflammation via galectin-anchored indoleamine 2,3-dioxygenase
*compartmentalisation - can’t blame autocorrect for that one 🤣
Great opportunities here @TCDPharmacy , with stipends to match the cost of living in Dublin - that is something you only see @tcddublin atm.
Get you applications in…….4 days left
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RT @lodrisc1
👇 Fully funded PhD positions (including €25,000 stipend/year to the students) in a range of pharmaceutical sciences and biomedical fields…. RTs appreciated https://twitter.com/TCDPharmacy/status/1646179011817615360
https://twitter.com/lodrisc1/status/1646202772189069342
RT @TCDPharmacy
We have some exciting #funded #PhD positions open for application in our School of #pharmacy (which is ranked very highly). See here https://pharmacy.tcd.ie/research/Panoz_PhD.php for more information and to complete the initial application form before 5th May!
Interesting analysis of manuscript retraction data, 2010-12 vs 2017-19:
-Increase in # of retracted papers
-Change in geographical origins.
😬
Data in figures shows groups of urban areas between which at least 2 retracted articles were co-authored.
https://dapp.orvium.io/deposits/6442fee5c93d17c257de17d2/view
Interesting 🤔. A common mechanism, located at the lysosome, linking amino acid and energy stress to organelle biosynthesis.
A few of my favourites in this one: #FNIP1 #AMPK #TFEB #mitochondria #mTORc1
RT @LabWaggoner
Slc46a2 is critical for transporting DAP-type peptidoglycans into keratinocytes, inhibited by the anti-inflammatory methotrexate, and works with the NOD1 pathway to incite psoriatic inflammation @SilvermanNeal @ImmunityCP
https://www.cell.com/immunity/fulltext/S1074-7613(23)00163-2
Gut bacteria move into tumours and support immunotherapies by metabolising tryptophan to make indole-3-aldehyde.
More reasons to take care of your gut microbiome.
😬😬 not sure I have any gut bacteria left after 9 weeks iv antibiotics 😬😩
RT @IamErikapalm
Here’s last week collection of papers on #metabolites in pathological #microenvironment and #immunometabolism !
@ImmunoMet @Bims_BiomedNews
👉🏽 http://biomed.news/bims-mepmim/2023-04-30
My highlight from Stuehr's lab on IDO and TDO regulation through control of heme allocation by #nitricoxide
Lots to be learnt about compartmentalism of metabolism inside immune cells.
Here they show cytosolic mitochondria enriched with different machinery to peri-lipid droplet mitochondria.
Burning lipid versus building lipid.
🔥 vs 👷
Lots of interest things in this paper but one thing that struck me was that:
"CD44 mediates the endocytosis of specific metals bound to hyaluronate, including copper".
A new transporter it would seem, at least to my knowledge anyway😁
How amazing are my ex PhD students @JesssicaW28 @loftusro @katiezyxw and @KediaMehta, who sent me this feel better soon package.
Including a mug with lab photos across the lifetime of the Finlay lab 🥰 and a lockpicking set - that’s an important skill to have 🤣
Thank you 😊
RT @VikiLovesFACS
@Win11We If that were true, it wouldn’t be worth offering COVID vaccination in pregnancy. But in fact, COVID increases the risk of preterm birth and stillbirth. Midwives, obstetricians and parents are all keen to avoid these, so vaccination is recommended.
RT @VikiLovesFACS
@Win11We I work in a maternity unit. So it would take a supreme amount of effort to avoid talking to midwives, and indeed obstetricians, since I see them every day.
RT @MitoPsychoBio
How we think and talk about mitochondria matters to our science and to newcomers in the field.
The powerhouse analogy is expired and we need specific vocabulary to capture the beautiful complexity of mitochondrial biology.
We propose a framework and some nomenclature.
RT @HaigisLab
When do cancer cells not run a complete NADH shuttle? Check out our latest study on the glycerol-3-phoshphate shuttle in kidney cancers @MolecularCell led by Conghui Yao, an amazing postdoc! https://www.sciencedirect.com/science/article/pii/S1097276523002137?dgcid=coauthor
RT @laoneill111
Can’t beat statistics…Irish workers are the most productive in the world.
RT @kzernike
A 14-yo girl read The Exceptions and painted this picture as a tribute to Nancy Hopkins and her groundbreaking science. The artist’s mother, also a fan, presented this to Nancy last week.
Here’s to the future.
RT @CathalHarmon
Research and Innovation Bill 2023: Open Letter to Minister Simon Harris - Sign the Petition! https://chng.it/xWfBzb6g via @Change
We are an Immunometabolism research group that studies how nutrients and metabolism affect immune cell function at #TrinityCollegeDublin👨🔬 Love #NK_cells, #Dendritic_cells and #T_cells but can be easily convinced to talk at length about metabolism in any immune cell 😄. Twitter handle @DavidFinlayTCD
Joined Nov 2022
