DaveFinlayTCD @finlayd@qoto.org
We are an Immunometabolism research group that studies how nutrients and metabolism affect immune cell function at #TrinityCollegeDublin👨🔬 Love #NK_cells, #Dendritic_cells and #T_cells but can be easily convinced to talk at length about metabolism in any immune cell 😄. Twitter handle @DavidFinlayTCD
Joined Nov 2022
RT @RafaJArguello
📢🙏 share and help us to find a motivated PhD candidate for an 🤯🤓🤩 opportunity at @CancerImmunoAMU
🧪🧠 Exciting #PhD call in #PediatricOncology! to advance #Medulloblastoma research using innovative single-cell metabolomic profiling! @SCENITHmetab #ImmunoMetabolism
1/
An interesting new double act!!
#Tcell immunotherapies engage #neutrophils to eliminate tumor antigen escape variants
RT @newscientist
Many people with obesity regain weight lost through diet and exercise programmes, but the health benefits remained even years later https://www.newscientist.com/article/2366432-losing-weight-is-good-for-your-health-even-if-you-regain-it/?utm_medium=social&utm_campaign=echobox&utm_source=Twitter#Echobox=1679999316-1
I never thought I would be a #mitochondria nerd, but here we are 🤷♂️🤣. Gonna enjoy reading doing of these articles.
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RT @CellPressNews
'The new @Molecular_Cell special issue focuses on the #mitochondria. The review articles in this issue focus on the diverse cellular processes involving mitochondria and the approaches used to study them. Take a look. https://hubs.li/Q01J2qN20
https://twitter.com/CellPressNews/status/1639328223816450048
RT @Morganti_Lab
Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration | Nature Metabolism https://www.nature.com/articles/s42255-023-00756-4
Striking changes in tumour infiltrating NK cell surface topology, observed using a range of Electron microscopy techniques - worth a look.
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RT @NK_papers
Tumors evade immune cytotoxicity by altering the surface topology of NK cells by Xiaohu Zheng https://ift.tt/Fj7tYX8
https://twitter.com/NK_papers/status/1639234763780390912
DaveFinlayTCD
boosted
RT @RyanLabTCD
New Ryan Lab preprint on the adaptive properties of forgetting - featuring the PhD research of Livia Autore, with @jamesoleary & @Clrar.
Adaptive Expression of Engrams by Retroactive Interference https://www.biorxiv.org/content/10.1101/2023.03.17.533126v1
RT @biorxiv_cellbio
Hexokinase 1 forms rings that constrict mitochondria during energy stress https://biorxiv.org/cgi/content/short/2023.03.20.533440v1 #biorxiv_cellbio
Mitochondrial damage activates the NLRP10 inflammasome
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RT @IIIBonn
We are super excited to share the newest publication from the Latz Lab @IIIBonn in @NatImmunol 🔥🎉
https://www.nature.com/articles/s41590-023-01451-y
A great collaboration with Franklin Zhong and @FISchmidtLab
Summary below, from twitterless 1st author Tom... 1/n
https://twitter.com/IIIBonn/status/1637848269681205248
RT @TCDPharmacy
We are hiring! We have four fantastic funded #PhDpositions open for applications here in the School of Pharmacy. Full information here https://pharmacy.tcd.ie/research/Panoz_PhD.php
Please retweet and share 😊
RT @RyanLab_MBU
Monocarboxylate transporters facilitate succinate uptake into brown adipocytes
Nice work @AnitaReddy1, @echouchani, @evanna_mills and team! Great to see the mechanism of uptake solved!
https://www.biorxiv.org/content/10.1101/2023.03.01.530625v1
M1 macrophage - fragmented mitochondria - glycolytic
M2 macrophage - elongated mitochondria - FAO
Also opposite to correlation described by Ngo et al. in non immune cells:
https://doi.org/10.15252/embj.2022111901
🤨 something different it’s going on in #Immunometabolism
Any other examples?
Effector CD8 T cells - fragmented mitochondria but glycolytic
Memory CD8 T cells - elongated mitochondria but use FAO and OXPHOS
Opposite way around to mechanism described by NGO et al.
🤔 Food for thought..
Other Immunometabolism examples? Reply..
(From Erika Pearce’s lab)
Oooooo, what’s that…mitochondria morphology controls Fatty acid oxidation (FAO). 🤔
Fragmented - CPT1 more active - ⬆️ FAO.
Elongated - CPT1 more sensitive to inhibition - ⬇️ FAO
Does this fit with what we know about Immunometabolism? 🤔🤨🧐
RT @FrezzaLab
If you are looking for a post doc in immunemetabolism, look no further. Dylan is an exceptional scientist! 👇👇🔥🔥 https://twitter.com/RyanLab_MBU/status/1636713209913569281
RT @laoneill111
Great opportunity to join Dylan Ryan’s lab - you won’t work with a better PI in a superb area with huge potential. https://twitter.com/ryanlab_mbu/status/1636713209913569281
Amazing opportunity for anyone looking for a postdoc. #immunometabolism, #mitochondria and the chance to work with the immensely talented Dylan Ryan
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RT @RyanLab_MBU
🚨To #immunometabolism and #mitochondria lovers everywhere🚨
There is an opportunity to join the newly minted Ryan group @MRC_MBU @Cambridge_Uni as a postdoctoral research associate.
Please check out the advert below and I appreciate any shares⬇️⬇️⬇️
https://www.nature…
https://twitter.com/RyanLab_MBU/status/1636713209913569281
RT @OxfordDiplomat
An absolutely stunning video from Ireland’s Department of Foreign Affairs and Trade, celebrating not just St Patrick's Day, but a Century of Peace building, 100 years after our independence. Happy #StPatricksDay
one and all ☘️ #GlobalIreland 🇮🇪
RT @LabWaggoner
Novel mouse models based on intersectional genetics to identify and characterize pDCs @NatImmunol #valente @DalodCiml #Tomasello
https://www.nature.com/articles/s41590-023-01454-9
RT @LabWaggoner
Protein posttranslational modifications can break tolerance to the self-proteome: metabolite-induced cysteine carboxyethylation generates neoantigens that may fuel autoimmunity @ScienceMagazine
https://www.science.org/doi/10.1126/science.abg2482
news: https://www.science.org/doi/10.1126/science.adg3925
We are an Immunometabolism research group that studies how nutrients and metabolism affect immune cell function at #TrinityCollegeDublin👨🔬 Love #NK_cells, #Dendritic_cells and #T_cells but can be easily convinced to talk at length about metabolism in any immune cell 😄. Twitter handle @DavidFinlayTCD
Joined Nov 2022
