Thomas Pradeu @pradeu@qoto.org

12/5/22 PNAS: Noninvasive detection of any-stage #cancer using free #glycosaminoglycans https://buff.ly/3Has7Zt

Urine  and  plasma free  glycosaminoglycan  profiles (#GAGomes)  are powerful multi-cancer early detection (MCED) metabolic biomarkers, potentially doubling the number of Stage I cancers detectable using genomic biomarkers such as serum circulating free DNA (cfDNA).

#EarlyDetection #Cancer

Thirty years ago, in November 1992, Ishida, Honjo and their collaborators reported the discovery of the #PD1 gene in @embojournal

https://www.embopress.org/doi/abs/10.1002/j.1460-2075.1992.tb05481.x

I spoke with Tasuku Honjo, Pierre Golstein (whose team first cloned #CTLA4) & Facundo Batista about the discovery earlier this year.
The initial project had absolutely nothing to do with checkpoints or #immunotherapy

Listen to the full #EMBOPodcast episode at the link below or on pretty much any podcast app

#Immunology #HistoryScience #Cancer #CellDeath

https://www.embo.org/podcasts/from-cell-death-to-cancer-immunotherapy/

Let’s make the science move to #mastodonmigration a definitive thing.
---
RT @cyrilpedia
The community is growing over there - I even have a range of science-Luis friends to choose from, with @lmvteixeira at

@lmvteixeira

& @LuisMateusRocha at

@lmrocha
https://twitter.com/CyrilPedia/status/1600525806924595200

Ok, friends. I'm shutting things down on the bird app in the next two days and will be found on : @NicoleKing

Hope to see you there!

Hey! Im a researcher of host-microbe interactions with a focus on bees! My research group is based at the Silwood Park campus of Imperial College London. We're particularly interested in exploring how microbes transmit & what their impact is on pollinator systems. Where possible we try to employ new techniques or combine multiple cutting-edge processes at once.

#Pollinators #parasites #microbiome #SilwoodPark #ImperialCollegeLondon #Ecology #Microbiology #ScienceMastodon #Biology #Evolution

Le #CNRS demande désormais à ses chercheurs et chercheuses d’appliquer la stratégie de non-cession des droits d’auteur (CC-BY 4.0) lors du dépôt de leurs articles auprès d’éditeurs.

https://www.cnrs.fr/fr/cnrsinfo/il-ny-pas-de-raison-que-les-scientifiques-fassent-une-cession-exclusive-gratuite-de-leurs

#Introduction - part II. To be a bit more specific about my #research I work on (and I'm fascinated by) asymmetric cell division. I'm interested on how cell polarity and mitotic spindle orientation are coordinated. I use the #Celegans embryo as a model, and often take a #genetic approach. #Science #ScienceMastodon #Biology #Genetics

#introduction: I am an Independent Fellow at #UniversityofNottingham running a research group focussed on using #bioinformatics, #microbiology, and #evolution to understand microbe-#microbe interactions in the human #microbiome (primarily in #cysticfibrosis).

"Here, we developed a computational model to interrogate antibody evolution by affinity maturation after immunization with two types of immunogens: a chimeric heterotrimeric antigen that is enriched for the RBS epitope relative to other B cell epitopes, and a cocktail composed of three non-epitope-enriched homotrimeric antigens that comprise the chimera."

#Immunology #Preprint

https://www.biorxiv.org/content/10.1101/2022.12.02.518838v1?med=mas

"Here, we analyze the consequences for CD8+ T cells of STAT3 GOF SH2 (K658N) or TA (T716M) domain mutations in the mouse germline and in people with germline STAT3 GOF syndrome. The findings demonstrate that diverse STAT3 GOF mutations cause oligoclonal accumulation of T-LGL-like effector CD8+ T cells and that the accumulation of these rogue T cells contributes to autoimmune pathology."

#Immunology #Autoimmunity #immunity

https://www.cell.com/immunity/fulltext/S1074-7613(22)00591-X?rss=yes&utm_source=dlvr.it&utm_medium=twitter

An #introduction into our work on #glycotime! We are a lab joint between the Francis Crick Institute and the Department of Chemistry at Imperial College London. We develop what we call chemical "precision tools" to investigate protein #glycosylation. These tools are specific for individual #glycosyltransferases, #glycan subtypes or cell lines. We employ methods of #chembio including #OrgChem, protein engineering, #glycoproteomics, #imaging, #chemoenzymatic synthesis and drug discovery.

Intro post: We are a #Immunology lab at the Rockefeller University in NYC. We're interested in B cells and the #antibodies they make. We also develop LIPSTIC technologies to study how immune cells interact.

Shamelessly plagiarizing @ct_bergstrom, here's a perfect germinal center for your trouble.