rastinza @rastinza@qoto.org

#ancheOggiSèMangiato hoy se come lirios, un pescado que está muy bien, me gusta y es barato!

Ma che diamine, io non capivo queste opposizioni al passante di Bologna.
Poi sono andato a vedere ed a quanto pare non è un passante ferroviario.

Ma Cristo, basta con le strade e giù coi treni!

#housing #rent

Today I was talking with a friend in Italy and I mentioned that I rented a flat and I'm renting out the other rooms.
He asked me why I don't buy a flat and do the same.

I do believe he has got a point, since I'm likely going to stay here for some years.
My salary is not very high, but I should be able to get a mortgage for a cheap flat in the center of Santiago.
In Santiago housing is quite expensive, much more than outside the city, however cheap housing is quite scarce, so it should be easy to rent out the rooms if I do so.

However it's not yet clear to me how advantageous this would be; not accounting any expenses and assuming the rooms are rented all the time I should be able to get the monthly mortgage payment through rents and a bit more.
Now I'd like to understand if that bit more that I'm getting will be sufficient to pay for expenses and periods I'm not able to rent.
It could be a bit risky to do so because the down payment would require most of my savings and maybe I'll have to raise some money through friends or family; but I'm quite sure I'd be able to rent out the rooms.

My other concern is that housing outside Santiago is much cheaper, thus I'm not so sure that a house in the center will actually retain it's value in the future.
I do not have a car, thus buying a house outside the city would be senseless.

Do you have advices and resources I could study to make a more reasoned choice?

Hay ido a Noia ayer por el concierto de Baiuca
Me gustó muchísimo!
El solo problema es que volvió a casa a las 5 y empiezai a trabajar esta mañana a las 8

#cancer #medicine #malaria

I made a few approximate calculations to estimate the importance of finding effective cures for cancer.
These are very rough estimates based on uncertain data, but definitely help understanding what we're trying to do and the importance of it.
I compared cancer with another disease: malaria.
There's no particular reason as to why I chose malaria, other that it's quite a widespread disease that causes a lot of troubles in certain places.

At the end of the toot I link all the sources I used, so that you can replicate the calculations if you wish; if you're going to do that maybe search for some better data, I didn't do any extensive research.
All data is referred to 2019, so we can exclude any effects due to covid limiting access to cures.

The cancer mortality rate changes with age, most people who die of cancer have more than 70 years.
Cancer deaths under 14 years: 0.40% of the total
Malaria deaths under 14 years: 56.81% of the total

Cancer total deaths: 10 million
Malaria total deaths: 558,000

Cancer deaths under 14: 40,000
Malaria deaths under 14: 317,000

So, as you can see cancer kills many more people than malaria, almost 18 times as many; however most of those people have more than 70 years and the global life expectancy is 73 years, thus it is not decreasing the length of life of people significantly.
Malaria kills much less people, however most of the people who die of malaria are children below 5 year, thus malaria kills most of the people 65 years before they would be expected to die.

Even though malaria kills less people than cancer overall, it kills almost 8 times more children below 14 than cancer.

I believe this rush in investing to find a cure for cancer to be stupid.
It would be nice to find a cure for cancer, but I believe there are more important diseases to cure in the world.
Unfortunately, most of the money and even public research is focused on cancer and not other critical diseases.

Sources:
https://ourworldindata.org/grapher/malaria-death-rates-by-age?country=~OWID_WRL
https://ourworldindata.org/grapher/cancer-death-rates-by-age?time=latest&country=~OWID_WRL
https://www.who.int/news-room/fact-sheets/detail/malaria
https://jamanetwork.com/journals/jamaoncology/fullarticle/2787350
https://ourworldindata.org/life-expectancy

#research #protein #proteins

Is there any expert of proteins?
I need help understanding protein flexibility and what are the main determining structural features.
Ideally, I'd like to be able to roughly estimate the flexibility of a protein using its structure or sequence.