rastinza @rastinza@qoto.org
Italian, MSc in chemistry specialized in cheminformatics and QSAR.
I'm interested in cooking and building stuff.
I love traveling, I lived in India, China, Slovenia, Poland and Spain.
Currently working in Spain in the field of genomics; and doing a PhD in Drug Development using Quantum Mechanics and Artificial Intelligence.
Don't take what I say as an insult, I have no bad intentions and I'm open to talk about it.
Don't star my toots, I find that often useless: if you liked it send a reply.
Consider boosting the toots, it's the only real way in which stuff is propagated through mastodon.
Joined Feb 2022
#mastodon
I wish there was a way to subscribe to people's posts and not their retoots
rastinza
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@rastinza io non sono contro la violenza, ma mi è molto chiara la differenza tra violenza e oppressione. il tornaconto personale non può giustificare l'oppressione, e in questo non vedo come la specie di apprtenenza possa fare alcuna differenza. @Fittoveg
@aleff e in generale, spero tu non prenda questo thread come un processo o simili, non è minimamente nelle mie intenzioni. qui, con tutti i limiti del mezzo, quello che tento di fare è di dibattere e crescere :)
#medicine #pharmaceutical #explaination
Some information about how new medicines are made by a guy who read a bit about it.
Most medicines target a particular protein in the human body.
The objective is to have something that interacts with the protein so that the function of the protein is altered.
Many things can be used to alter those mechanisms, such as small molecules, other proteins, antibodies and other things.
These things hopefully go nearby the protein of interest and modify its shape or block some part of it.
It is difficult to find one such thing that modifies the function of the protein in the desired way that is expected to cure the disease.
It's even more difficult to find one who does not interact with other proteins and causes toxic side effects.
I'll quickly outline some methodologies used to find small molecules that can act as medicines.
Small molecules are molecules made up of atoms with a contained dimension, much smaller than the common protein.
One very simple way to find such a molecule is to test a lot of different molecules with the protein in a laboratory and observing if something good happens.
This methodology is pretty good since it requires no prior knowledge about the protein nor about the molecules you're testing.
This procedure however also has some downsides: you need to obtain all the molecules you need to test and you need either a lot of people testing them or some specialized machinery.
This is of course very expensive.
Moreover, if none of the molecules you were able to obtain are good for curing the disease, you just spent a lot of money and gained little information about how to cure the disease.
This first methodology is very widespread in the big pharma industry, since they have the means to sustain the costs of a potentially fruitless expense.
It is difficult to find this kind of methodologies used in universities and research institutions, due to more limited budget.
Alright, this was a first quick introduction to the theme, if you're interested I can write a bit more; trying to keep it simple.
Let me know what you could be interested in knowing.
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Hello World!
GIMP project now gets a new official Mastodon account! 🥳
We can see the info leaked somehow (we had not announced it and already got 150+ followers in 2 days) 😂.
GIMP news will be coming here too, from now on!
Note: illustration by Aryeom (edited from her original video "What is the Fediverse?"), licensed under Creative Commons Attribution-ShareAlike 4.0 International.
Otra noche hablando con dos chicos
El pescado de Galicia es el mejor del mundo
> Y lo del reino unido?
Una mierda
> Y lo de Portugal?
Pésimo
Vale, nos vemos otra vez
Searching some stuff on Google
> Do you want to play a game?
Sure
Apparently solving some problems for a Google interview or something like that
Sure thing, got nothing better to do anyways...
rastinza
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(Image of a single eye in bright colours)
Do you like this as a design for clothing/accessories/stuff?
rastinza
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IN FAMIGLIA
"Buongiorno, servizio informatico"
"Haju scurdatu a password picchì nun la mintu mai, havi misi ca nun trasu no computer" [Ho dimenticato la password perché non la metto mai, non entro nel computer da mesi]
"Mi dica il suo cognome"
"Certo, è *****"
"La sua matricola è per caso *****?"
"No no, chiddu è me cuscinu ca travagghia n'o stissu pustu [No quello è mio cugino che lavora nello stesso posto]"
MA GUARDA CASO
#BuongiornoServizioInformatico
#SoloNellaPubblicaAmministrazione
rastinza
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📫 Whether you’re subscribed to a lot of podcasts or just a handful, you want to know what’s the next thing to play. Version 2.7 of AntennaPod introduces a better way to do just that: the Inbox!
Find out more about the Inbox and other enhancements on our blog 👇
https://antennapod.org/blog/2022/10/2-7-release
rastinza
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I wrote a blog post about the modifications of the Kobo e-readers to make them more pleasant to use
the text is in French but you should understand it using an automatic translator
if some passages are not understandable, don't hesitate to send me a message and I'll try to explain it to you :)
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@rastinza
Fiúncho, loureiro (de esquerda a dereita)... Non distingo ben a terceira herba... Nébeda?
rastinza
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contiene birra
Ho notato che l'etichetta della Poretti 4 luppoli dice "4° luppolo coltivato in Italia".
E gli altri 3?
Ah, l'etichetta degli ingredienti dice che vengono da due posti ben localizzati: UE e non-UE.
rastinza
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Hoy he ido a una montaña cerca de Santiago; un buen paseo y he encontrado algunas cositas.
No hai setas però...
rastinza
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Yeah, so, earlier today I shared my daily drawing here.
And a troll decided that I needed to be told I need to kill myself.
It's "hard out here for a bitch", so I blocked them and their instance.
If anyone on this instance has anything like this happen to them, please report! @darth_mall and I will do our best to protect you.
We are still such a small instance, not a lot of attention, but as we grow we need to support each other when dealing with these trolls.
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And these AI tools aren't the first time we've encountered these issues. Scientists, and just about anyone putting together a slide deck, has 'lifted' art for decades.
Do read Glendon's thread. He's done a very good job of explaining the issues.
rastinza
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Had a great first #OpenPodcastAPI meeting yesterday. Initial focus: allowing users to sync their subscriptions & listening activity between podcatchers, webapps & sync servers.
Many thanks to the folks from @AntennaPod, @funkwhale, @kasts and @martin from Podfriend and @JonOfUs from the gPodder Nextcloud app.
Further discussions taking place here: https://github.com/orgs/OpenPodcastAPI/discussions Anyone interested in creating & implementing this open spec is welcome.
Italian, MSc in chemistry specialized in cheminformatics and QSAR.
I'm interested in cooking and building stuff.
I love traveling, I lived in India, China, Slovenia, Poland and Spain.
Currently working in Spain in the field of genomics; and doing a PhD in Drug Development using Quantum Mechanics and Artificial Intelligence.
Don't take what I say as an insult, I have no bad intentions and I'm open to talk about it.
Don't star my toots, I find that often useless: if you liked it send a reply.
Consider boosting the toots, it's the only real way in which stuff is propagated through mastodon.
Joined Feb 2022
