Sandra Laurentino @SandraLaurentino@qoto.org

My colleague Joachim Wistuba is looking for a #PhDstudent for his fully funded
@dfg_public project on #KlinefelterSyndrome Deadline for application 27th December. More information on the position and how to apply here: https://jobs-sf.ukmuenster.de/job/UKM-Wissenschaftlicher-Mitarbeiter-%28gn%29/1011115001/
#PhDposition #Reproduction #Andrology

Such a stimulating session this morning on male infertility, I loved how many unexpected points of contact there were between the different speakers and what great company I was in. Thank you to Don Conrad and Maris Laan for the invitation to present my work on male reproductive ageing here.
#ASHG23

Really enjoyed the session on genome interpretation and functional studies. Lots of great work on splicing changes, an ongoing (side) interest of mine, including new validation strategies.
#ASHG23 #ASHG2023

Really interesting selected talk by Christina Falugi about use of "natural" vs traditional photos of patients to showcase phenotypes. Perception is more positive with natural ones without difference in educational value. Time to retire some awful photos from textbooks?
#ASHG223

Random 1st impressions of the #ASHG2023:
🧬It's not a large meeting, it's absolutely gigantic
🧬Conference ribbons are a thing
🧬Opening address included security advices for participants
🧬Closed captions, I assume automatic/AI, are getting some words very, very wrong

Great to see the consequences of advanced paternal age given attention by The Guardian.
If anyone is attending #ASHG23 next week and wants to hear more, I'm giving a talk about this (and more).

"But problems pile up as a man gets older. Stem cells acquire more mutations. Epigenetic marks get modified. Experiences in the man’s life, including environmental exposures, cause oxidative stress and damage. These things, and more, may act in concert to cause the effects researchers are seeing in children born to older fathers.

What’s clear is that paternal age matters – and that more men are becoming older fathers. As Robaire and Chan write, a number of factors including delayed marriages, second marriages, assisted reproduction, treatments such as Viagra for erectile dysfunction, and celebrity men modelling older fatherhood “have provided elements for a perfect storm”."

https://www.theguardian.com/science/2023/oct/22/the-perils-of-putting-off-fatherhood-why-it-poses-risks-to-childrens-physical-and-mental-health?CMP=share_btn_tw

3rd Virtual Symposium on Male Reproductive Immunology organised by the colleagues from Giessen will take place 29th-30th November. Great program and attendance is free!

The seminar series “Human Reproduction: Researching the Secrets of Life” will take place from Monday, 25 September until Thursday, 28 September 2023, every day 1:00 - 1:50 pm (CEST).
The seminar will be live-streamed via ZOOM (link to follow).

Our new work was just published on BMC Bioinformatics
OGRE: calculate, visualize, and analyze overlap between genomic input regions and public annotations
https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-023-05422-w
OGRE is a #bioinformatics tool that calculates the overlap between a set of genes or regions (e.g. coming from RNA-seq) and publically available #genomic annotations (e.g. TFBSs). It was developed to be easy to use and with scientists without computational training in mind.
It's available on @bioconductor https://bioconductor.org/packages/devel/bioc/html/OGRE.html and on
@GitHub https://github.com/svenbioinf/OGRE