Johannes W. Dietrich @drjwdietrich@qoto.org
- Sektion DES / Klinik
- http://www.endokrinologie.org
apl. Prof. Dr. med. Johannes Dietrich, endocrinologist, head of the diabetes, endocrinology and metabolism section of #KKB @RUBMedizin. Views are my own.
Joined Nov 2022
Johannes W. Dietrich
boosted
In an adjusted model, #SPINA_GD correlates significantly with type 2 allostatic load. It parallels the association to central markers of thyroid homeostasis, underscoring the TSH-T3 feedforward control.
https://pubmed.ncbi.nlm.nih.gov/41941533/
https://doi.org/10.1080/10253890.2026.2653858
Ich weiß ja nicht, wer mich vorgeschlagen hat, aber ich bin ab sofort im (ursprünglich 1925 begründeten) Kürschnerschen Deutschen Gelehrtenkalender aufgeführt. Nicht allzu wichtig, aber ganz nett 😅. Ob man aber für die 4 Bände über 1000 € ausgeben möchte...?
https://www.degruyterbrill.com/document/isbn/9783111635460/html
Die politischen Rahmenbedingungen der präventiven Medizin sind in Deutschland unzureichend. Zusammen mit anderen Europäischen Ländern ist Deutschland Schlusslicht in der #Prävention. Das führt dazu, dass die Kosten hoch sind, aber die Lebenserwartung niedrig.
https://blog.endokrinologie.net/politische-rahmenbedingungen-der-praeventiven-medizin-6001/
Mathematical modelling, computer #simulation, and machine learning upgrade #endocrinology. Applying principles of #biocybernetics and #biophysics, they enjoy growing interest and deliver novel methods for research, diagnosis, and therapy.
https://pubmed.ncbi.nlm.nih.gov/41852474/
https://doi.org/10.3389/fendo.2026.1806508
Johannes W. Dietrich
boosted
#SimulAdren, based on #CyberUnits Bricks, has been upgraded to version 1.3 (Green Lizard). This version introduces functionality to save plots and the block diagram of the information processing structure as graphics files.
https://simuladren.sourceforge.io/
https://doi.org/10.5281/zenodo.16324703
https://doi.org/10.5281/zenodo.19010509
Johannes W. Dietrich
boosted
#Trndi is a #glucose monitoring application written in #Object_Pascal. It fetches interstitial sugar readings from continuous glucose monitors (CGM) via different APIs and shows them on the desktop. It also presents a trend over time, colouring, and JavaScript extensions.
Johannes W. Dietrich
boosted
The #Lazarus_IDE for #Free_Pascal has been updated to version 4.6, fixing bugs and updating localisations.
www.lazarus-ide.org
#MCT8 Deficiency, or Allan-Herndon-Dudley syndrome, is a rare severe disorder of #thyroid hormone transport. In our newest paper, we review the state of the art on pathophysiology, diagnosis & treatment.
https://pubmed.ncbi.nlm.nih.gov/41508830/
https://doi.org/10.1210/clinem/dgaf707
https://www.livivo.de/doc/M41508830
Systems modelling explains: A #cybernetic theory of the molecular processes in #COVID-19 predicts oscillatory #inflammation and virus load in severe forms, which result from increased #TMPRSS2 expression.
Severe #COVID-19 is a life-threatening condition, sometimes requiring #ECMO (extracorporeal membrane oxygenation) therapy. In one of our studies, we found that oscillatory inflammation heralds a poor prognosis.
https://pubmed.ncbi.nlm.nih.gov/36991018/
Die #Leibniz-Sozietät der Wissenschaften hat unser neues Buch zur #Hypothyreose auf ihrer Homepage hervorgehoben.
https://leibnizsozietaet.de/neue-publikation-unseres-mitglieds-johannes-w-dietrich/
#Endocrine feedback loops belong to the important foundations of life. However, consistent underlying rules are still lacking. Now, Moriya Raz, Uri Alon, and co-authors describe 5 classes of control circles.
https://www.livivo.de/doc/M41271754
https://pubmed.ncbi.nlm.nih.gov/41271754/
https://doi.org/10.1038/s41467-025-65924-4
#Takotsubo syndrome is a dangerous stress-related #heart disease. Since #T3 upregulates β-receptors, we assumed a link to #thyroid homeostasis. With machine learning, we identified interesting allostatic patterns.
https://www.livivo.de/doc/M33179374
https://pubmed.ncbi.nlm.nih.gov/33179374/
https://doi.org/10.1111/joim.13189
Johannes W. Dietrich
boosted
#SimulAdren has been released in version 1.1. This cross-platform simulator of the corticotropic feedback loop (hypothalamus-pituitary-adrenal or #HPA axis) is based on the #CyberUnits Bricks class library.
https://doi.org/10.5281/zenodo.16324703
https://doi.org/10.5281/zenodo.17924621
https://simuladren.sf.net
Therapy with #TRIAC, a non-classical #thyroid hormone, relieves peripheral #thyrotoxicosis and hypermetabolism in patients with resistance to thyroid hormone β (RTHβ).
https://pubmed.ncbi.nlm.nih.gov/41131705/
Systems Endocrinology: Shaping a new medical discipline with Object Pascal
#Pascal programming
#Systems_Endocrinology
#P4_Endocrinology
#Systems_Medicine
Johannes W. Dietrich
boosted
A new #TRURL app has been released. TRURL B follows the design of the famous calculators created by Dietrich Lubs and Dieter Rams for the German company Braun.
It implements all fundamental operations plus power, square, square root, and the inverse operation.
Johannes W. Dietrich
boosted
There is an ongoing debate in #endocrinology about whether to treat #hypothyroidism with L-T4 alone or a combination therapy with L-T4 and L-T3. But what about patients’ preferences? The majority would choose the combination therapy, as shown in a meta-analysis.
Die Veranstaltung ist am 3. September 2025, 16:30 Uhr bis 19:00 Uhr.
Ort: Hörsaaltrakt der Universitätsklinik St. Josef-Hospital Bochum
- Sektion DES / Klinik
- http://www.endokrinologie.org
apl. Prof. Dr. med. Johannes Dietrich, endocrinologist, head of the diabetes, endocrinology and metabolism section of #KKB @RUBMedizin. Views are my own.
Joined Nov 2022
