DaveFinlayTCD @finlayd@qoto.org

This study is exciting because it uses a direct intervention, using a recombinant anchored enzyme, to change nutrient levels within a local micro environment.

What enzyme would you like to use therapeutically?

And into what micro environment would you like to anchor it?

/end

IDO-Gal3 reduces the severity of symptoms in mice with established osteoarthritis.

They also show anti-inflammatory effects in skin inflammation and that IDO-Gal3 averts and inhibits periodontal disease progression. (4/5)

Using a mechanical overloading osteoarthritis mouse model, mice were treated weekly with intra-articular IDO-Gal3 injections.

You can clearly see the retention of Gal3-IDO in the joint. (3/5)

Key advance:

Generating an IDO-Gal3 fusion protein.

Gal3 binds to fly and in the extracellular matrix (ECM) of tissues, anchoring IDO in place at the site of inflammation - very clever IMHO. (2/5)

Harnessing anti-inflammatory potential of IDO.

Exciting new approach by @keselowsky, @GregHudalla using IDO therapeutically as an anti-inflammatory . (Short 🧵 1/5)

Suppression of local inflammation via galectin-anchored indoleamine 2,3-dioxygenase

https://www.nature.com/articles/s41551-023-01025-1

*compartmentalisation - can’t blame autocorrect for that one 🤣

Great opportunities here @TCDPharmacy , with stipends to match the cost of living in Dublin - that is something you only see @tcddublin atm.

Get you applications in…….4 days left
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RT @lodrisc1
👇 Fully funded PhD positions (including €25,000 stipend/year to the students) in a range of pharmaceutical sciences and biomedical fields…. RTs appreciated https://twitter.com/TCDPharmacy/status/1646179011817615360
https://twitter.com/lodrisc1/status/1646202772189069342

Interesting analysis of manuscript retraction data, 2010-12 vs 2017-19:
-Increase in # of retracted papers
-Change in geographical origins.

😬

Data in figures shows groups of urban areas between which at least 2 retracted articles were co-authored.

https://dapp.orvium.io/deposits/6442fee5c93d17c257de17d2/view

Interesting 🤔. A common mechanism, located at the lysosome, linking amino acid and energy stress to organelle biosynthesis.

A few of my favourites in this one: #FNIP1 #AMPK #TFEB #mitochondria #mTORc1

https://doi.org/10.1126/science.abj5559

Gut bacteria move into tumours and support immunotherapies by metabolising tryptophan to make indole-3-aldehyde.

More reasons to take care of your gut microbiome.

😬😬 not sure I have any gut bacteria left after 9 weeks iv antibiotics 😬😩

https://doi.org/10.1016/j.cell.2023.03.011

Lots to be learnt about compartmentalism of metabolism inside immune cells.

Here they show cytosolic mitochondria enriched with different machinery to peri-lipid droplet mitochondria.

Burning lipid versus building lipid.

🔥 vs 👷

https://doi.org/10.1016/j.celrep.2023.112435

Lots of interest things in this paper but one thing that struck me was that:

"CD44 mediates the endocytosis of specific metals bound to hyaluronate, including copper".

A new transporter it would seem, at least to my knowledge anyway😁

https://doi.org/10.1038/s41586-023-06017-4