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As some of you know ive been on #Ozempic / #Wegovy / #Semiglutide once daily instead of the usual weekly.
I created a log of my historic blood accumulation when i was on once weekly and now that im on a daily adjusted dose. The blue lines show total amount in my blood, red i dicates equivelant weekly dose based on daily dose x7 and yellow is based on expected blood concentration.
As you can see the daily dosing produces much more constant levels. This is based on the typocal 7 day half life.
@LouisIngenthron A bit. I figure i will step down gradually and watch my weight. If it needs to be forever its still a solution and im ok with that.
@freemo The rule of thumb in Pharmacology is 2 to 3 half lives with daily dosing before the Limit is approximately reached.
I learned that after around 10 pages of calculations and a professor told me that it didn't need to be that precise. Nice graph, SAGE was the best experience I've ever had with Mathematics Software. Graphs set to output into a LaTeX document or Beamer Presentation, oh god it was amazing.
I wish you well on your journey. Scuba will be a little different now but I'm sure you can handle it.
@AmpBenzScientist Generally most medications are dosed per half life. But daily dosing should get you to saturation about as quickly as dosing per half life.
General rule is closer to 3 or 4 half lives
Im honestly not sure if scuba will be effected at all
@freemo That's probably the correct estimation. I had the joy of using Adderall as the drug for estimating concentration. It has only two enantiomers, what could be complicated about it? It was only two doses per half life of the S enantiomer.
The previous Mathematical Model was of Paramecium Plasmodium with treatment and natural reservoirs. I chose a specific variant with some treatment resistance and chloroquine as the only treatment. Oh that was a fun model.
@freemo Are you concerned at all about what happens when you stop using it? Or are you considering using it indefinitely?