Hao Yin @HaoYin@qoto.org
Cardiovascular biologist, Dr. J. Geoffrey Pickering lab, Robarts Research Institute, Western University, London, Ontario, Canada
https://scholar.google.ca/citations?hl=en&user=IbrDx00AAAAJ&view_op
Joined Nov 2022
Spatial Atlas of human Lung
Spatially-resolved multi-omics-> #AirwaySubmucosalGland-associated Lymphoid niche for IgA #PlasmaCell + T cells via CCL28/IL6/APRIL paracrine
5 locations, 13 patients
Systemic vs Pulmonary vascular trees
Immune recruiting venous NG2-ABCC9+ICAM1+ #Pericyte is abundant in CCL2/19/21 & CXCL12🤠
Love to dig into transcriptomes of systemic vs pulmonary #SmoothMuscleCell & pericytes along the bronchial tree😋
A spatially resolved atlas of the human lung characterizes a gland-associated immune niche
Love this powerful molecular micro-anatomy for human Lung👍
A great starting point for my Holiday-specific continued biomedical education on Lung🎄
Dr. Sarah Teichmann & Kerstin Meyer lab Nature Genetics 2022
https://www.nature.com/articles/s41588-022-01243-4
Bioelectrical initiation of HeartBeat👹
"a noisy saddle-node on invariant circle bifurcation as the critical phase transition that starts the heart"
A wild & cool piece from Dr Sean Megason & Adam Cohen labs bioRxiv 2022 @SeanMegason @AdamEzraCohen
https://www.biorxiv.org/content/10.1101/2022.12.06.519309v1.full
Also do not miss this great thread from 1st Author @BillZJia
https://twitter.com/BillZJia/status/1601193364451250176
Tumor spheroid-microvasculature-on-a-chip
#Microfluidic
0.6×0.3×25 mm
5 & 15 dyn/cm2
MCF-7 spheroid
HUVEC monolayer
Tumor spheroid alters #EndothelialCell polarization to shear🤠
Sheared EC⏬spheroid growth🤠🤠
Dr. Hongxu Lu & Lining Arnold Ju labs bioRxiv 2022
https://www.biorxiv.org/content/10.1101/2022.11.19.517181v1.full
Vascular #BehçetSyndrome: from pathogenesis to treatment
Superficial & deep vein Thrombosis in 50% patients
Arterial involvement
Thrombosis+Aneurysm of abdominal aorta, pulmonary artery, peripheral arteries
Wait for more human Genetics for this still-mysterious disease 🧐
Dr. Giacomo Emmi lab Nat Rev Rheumatol 2022
https://www.nature.com/articles/s41584-022-00880-7
5-channel (separated by microposts) #Microfluidic for #EndothelialCell-#Pericyte fibrin-
collagen co-culture
Human Lung fibroblast as feeder
Enable study of Synergy b/w #ShearStress & Pericyte on #SproutingAngiogenesis😁
Dr. Ryuji Yokokawa lab, Lab on a chip 2022
Innervation of #PosteriorTibialArtery by branching #TibialNerve
72 calves from 12♀️+24♂️donors
An anatomical basis for improving sympathectomy strategy to treat #ChronicLimbThreatheningIschemia
Dr. Yun Xie & Xiao-Zhen Zhao labs Clin Anat 2022
https://onlinelibrary.wiley.com/doi/abs/10.1002/ca.23997
MEG9/Mirg, a LncRNA in Dlk1-Dio3 cardio-angiocluster, links #DNADamage & #Angiogenesis
⏫by Genotoxic stress
⏬by VEGF/FGF2/Dll4/Jag1
🐭Mirg KO affects s.c. Matrigel vessel stability in a Sex-specific manner
Dr. Cristina Espinosa-Diez & Sudarshan Anand lab bioRXiv 2022
https://www.biorxiv.org/content/10.1101/2022.12.07.519382v1
#Leiomyoma with Bizarre Nuclei: A Current Update
Review on Uterine Smooth Muscle Tumors😎
Pathology & MRI
Differentiating LBN from
other Leiomyoma
USMT of uncertain malignant potential Leiomyosarcoma
Dr. Q Zheng & L Wang labs Int J Womens Health 2022
https://www.dovepress.com/leiomyoma-with-bizarre-nuclei-a-current-update-peer-reviewed-fulltext-article-IJWH
Sirt6⏬#Senescence & IL15-JAK3-STAT5-inflammation in adult #Chondrocyte
Deacetylated STAT5 by Sirt6 fails nuclear import
In contrast, Sirt6⏫p21->Senescence in embryonic chondrocyte
Dr. Ming-liang Ji & Jun Lu lab Nature Comms 2022
https://www.nature.com/articles/s41467-022-35424-w
An interesting chondrotrophic nanoparticle is used to deliver MDL-800, Sirt6 activator, in🐭DMM #Osteoarthritis
Chondrocyte-specific aptamer tgg2-functionalized PEGylated PAMAM nanoparticle
Originally used for microRNA Annals of the Rheumatic Diseases 2021
https://ard.bmj.com/content/80/3/356.abstract
Vascularization improves function performance of #hiPSC-β Islet #Organoid 🤠
Ca2+ as a surrogate for insulin secretion to high throughput screening
A role of #Angiocrine #BMP4 signaling & #BasementMembrane
Dr. Maike Sander lab bioRxiv 2022
https://www.biorxiv.org/content/10.1101/2022.10.28.513298v1.full
The lysosomal degraders
#PROTAC +derivatives
An update on Research & Commercialization of #MolecularGlue for targeted protein degradation
"LYTACs, ATACs, AbTACs, KineTACs, PROTABs, AUTACs, ATTECs and AUTOTACs"
Ken Garber Nature Biotech 2022
https://www.nature.com/articles/s41587-022-01594-7
#Mechanobiology🐭 Heart #Valvulogenesis
Spatiotemporal YAP nuclear patterning in Valvular Endothelium+Interstitium correlates with in vivo force transition
⏬by #LaminarShearStress
⏫by OSS
⏫by #CompressiveStress
⏬by #TensileStress
Jonathan Butcher Lab bioRxiv 2022
https://www.biorxiv.org/content/10.1101/2022.11.24.517814v1.full
Pathogenesis of #GiantCellArteritis with focus on cellular populations
Immune+Stromal cell dynamics
Cytokine signature
IL6-IL17
IL12-IFNγ
Immune Checkpoint
Immunosenescence
This is a very friendly review for a non-immunologist (me😄)
Dr. Pavlos Stamatis lab Front Medicine 2022
https://www.frontiersin.org/articles/10.3389/fmed.2022.1058600/full
An autosomal (Chr2) Myh11-CreERT2🐭model to enable #SmoothMuscleCell-specific KO & lineage tracing in Both MALE & FEMALE!👍
Previous mouse Myh11-Cre transgenes are Y-linked
Dr. Gary Owens lab ATVB 2022
https://www.ahajournals.org/doi/10.1161/ATVBAHA.122.318160
#4DFlowMRI to image Left Ventricle flow components & LA-LV local pressure in #BicuspidAorticValve with mild #AorticRegurgitation + preserved ejection fraction
51 BAV vs 24 Ctrl
Dr. Julio Garcia lab Front Carduivasc Medicine 2022
https://www.frontiersin.org/articles/10.3389/fcvm.2022.903277/full
Take a look at this amusing repair of 2-photon vessel injury by 2 adjacent #EndothelialCells
Dr Karen Hirschi & Valentina Greco labs bioRxiv 2022
https://www.biorxiv.org/content/10.1101/2022.11.02.514907v1.full
Diabetic Retinal Vasculopathy in #Zebrafish
5%-0% glucose alternating per 12 h for 30 d
⏫Vessel diameter
⏬ZO-1 tight junction
⏬SM22α+ mural cell coverage
Changes in other vascular beds?🧐
Dr. Cheol-Hee Kim & Seung-Hyun Jung labs IJMS_MDPI 2022
https://www.mdpi.com/1422-0067/23/23/15069⏬
IL-1β & Macrophage-like #SmoothMuscleCell/SMC-derived #FoamCell
scRNAseq👤calcified #Atherosclerosis (proximal vs core)->
Ligand-SMC receptor map + Mɸ-like SMC transcription network->
⏫IL1β-⏬STAT3
AAV9-Cas9-sgIL1β for🐭
Dr. Suxin Luo lab Comms Bio 2022
https://www.nature.com/articles/s42003-022-04255-2
In #BicuspidAorticValve #Aortopathy, #Aorta-enriched plasma cell-free DNA methylation correlated with ascending aortic #Apoptosis in regions of elevated #WallShearStress (4D flow MRI), but Not aortic diameter
An interesting method to identify tissue-enriched DNA methylation in this paper
Roadmap Epigenomics
BluePrint Epigenome
Metilene
https://www.bioinf.uni-leipzig.de/Software/metilene/
24 candidate aorta-enriched differentially methylated regions
4 used in this study
Dr. Steven Greenway lab Clin Epigenetics 2021
https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-021-01137-y
Splendid #SciArt by Kristy Red-Horse lab
Endocardial Origin of Coronary #EndothelialCell +Arteriogenesis
A fascinating BMP2+ transitioning e17.5 coronary EC population
How EC & nonvascular BMPs coordinate heart #Angiogenesis😆
Exogenous BMP2 synergizes with VEGF-A⏫endocardial-derived Angiogenic sprouting from e10.5🫀ventricle explants
LDN193189, BMPR inhibitor,⏬endocardial contribution to coronary vascularization
AAV9-cTnt-Bmp2⏫endocardial-derived angiogenesis in neonatal #MyocardialInfarction🤠
Dev Cell 2022 @kristyredhorse
https://www.cell.com/developmental-cell/fulltext/S1534-5807(22)00759-6
Cardiovascular biologist, Dr. J. Geoffrey Pickering lab, Robarts Research Institute, Western University, London, Ontario, Canada
https://scholar.google.ca/citations?hl=en&user=IbrDx00AAAAJ&view_op
Joined Nov 2022
