Show newer

Finally set up a mastodon account thanks to @DavidBrueckner.

I love paper tweetorials (now mastorials?) and the pics of weird creatures (especially fish, insects, and deep sea creatures)!

Here's my account @MikiEbisuya.

About time for an . My research group at the Wellcome Centre for Human Genetics in Oxford uses techniques and Genome Architecture Mapping to study and in rare .

I (He/Him) love to be outside or and I’m a big fan of travel. Interested in issues in STEM, trying to read and educate myself to be a better ally.

Toot at me with your theories!

Hi Mastodon, in my lab we use #stemcells and #organoids to find treatments for #mitochondria diseases.

Hi Mastodon community, here’s my #introduction I’m a #gastroenterology researcher at #UCL growing #IBD #organoids to investigate #inflammasome regulation and #autophagy

Intro post: I'm a physician-scientist in #Gastroenterology at #UniversityOfMichigan. My training is in #Epidemiology, #virology, and #InflammatoryBowelDisease. I study the gut #microbiome and host #immunity. As a #queer person in #medicine, I advocate for #LGBTQ health and #inclusive research.

For your trouble, here's a photo of some mucin.

#Introduction I am an immunologist and science communicator. My research encompasses a few fields so my interests pretty wide- infection, microbiome, pollution and immunology-technically I am a barrier immunologist. I also feel strongly science is something everyone should be able to access and understand the basics so that they can make informed decisions and make a difference to their lives and my public engagement work tries to embody that with a co-production approach throughout.

Hello👋 I’m a research fellow and psychiatrist at the University of Cambridge. I work on interactions between the immune system, brain and behaviour esp using #ImmunoGenetics approaches. Interested in #biomarker discovery in psychiatry. Looking forward to discussions on here! #genomics #immunopsychiatry #neuroscience #neuroimmunology #introduction

Hej there, our first mastodon post from #madrid !
Heading to Chile to give a talk at @asochin and @umayor!

In #Science (@sciencemagazine) this week, the Hanahan lab shows that the #RNA-binding protein #FMRP enables #tumors to evade being attacked by #CD8TCells. It does so by both suppressing #CCL17 & promoting #Tregs via #IL33 & #M2 #macrophages via #PROS1 & #ExtracellularVesicles!

bit.ly/Sci_abl7207

#CancerImmunology #RBP

My latest Clinical Pipeline column at is just out.

This was an interesting piece for me, to see what's going with drugs targeting family molecules in a clinical setting, in this case an activin receptor 2a/IgG1 Fc domain fusion protein selectively mopping up ligands. The drug's been through trials in oncology, thalassemia & other conditions, but it looks like it had a good hit in pulmonary arterial .

nature.com/articles/d41591-022


Hello! I am a PhD student in System Biology at . I am passionate about science and in love with
Bachelor in Biology-Genetics
Masters in Oncology (Brazilian National Cancer Institute),
I've been working on onco-immunology for 10 years. I started by improving CAR-T cell design, and in the last five years, I focused on understanding the tumor immune microenvironment using

Fat food for a day gives your intestine away… or something like that.

How the gut epithelium rapidly changes upon fatty diet. Withing 24 hours some cells in the intestine increased the activity of genes associated with stress and fat metabolism.

Very nice work from the Wells Lab:
cell.com/cell-reports/fulltext

"Here we show that individual Bmp ligands and Tgfβ drive distinct enterocytic programs specific to villus zonation. Bmp4 is expressed mainly from the center to the upper part of the villus, and it activates preferentially genes connected to lipid uptake and metabolism. In contrast, Bmp2 is produced by villus-tip mesenchymal cells, and it influences the adhesive properties of villus-tip epithelial cells and the expression of immunomodulators."

biorxiv.org/content/10.1101/20

Terminal differentiation of enterocytes is governed by distinct members of Tgfβ superfamily

The protective and absorptive functions of the intestinal epithelium rely on differentiated enterocytes. Their differentiation is orchestrated by sub-epithelial mesenchymal cells producing ligands along the villus axis, in particular Bmps and Tgfβ. Here we show that individual Bmp ligands and Tgfβ drive distinct enterocytic programs specific to villus zonation. Bmp4 is expressed mainly from the center to the upper part of the villus, and it activates preferentially genes connected to lipid uptake and metabolism. In contrast, Bmp2 is produced by villus-tip mesenchymal cells, and it influences the adhesive properties of villus-tip epithelial cells and the expression of immunomodulators. Hence, Bmp2 promotes the terminal enterocytic differentiation at the villus-tip. Additionally, Tgfβ induces epithelial gene expression programs similar to that triggered by Bmp2. Bmp2-driven villus-tip program is activated by a canonical BmpRI/Smad-dependent mechanism. Finally, we established an organoid cultivation system that enriches for villus-tip enterocytes and thereby better mimics the cellular composition of the intestinal epithelium. Altogether our data suggest that not only Bmp gradient, but also the activity of individual Bmp drives specific enterocytic programs.

www.biorxiv.org

Re #introduction

Hey everyone, I'm Prathyusha, a postdoc at Dana-Farber/Harvard Medical School. My PhD research was in #cancer #immunology and my current research interests are in #immunology and #genetics of #kidneycancer

I enjoy reading and painting as a hobby.

I mostly toot about science and occasionally you'll find random musings, food, and paintings (though life has been too busy lately to focus on the last).

Here to meet the fun #academic and #scientific community! #ScienceMastodon

Just getting set up on here. Looking forward to connecting with the #immunology #science mastodon community!

Nice study showing Candida albicans lipase suppressing host IL-17 responses & promotes invasive infection.

Caveats re model systems used, etc.. but interesting demonstration of pathogen evasion of protective host immune responses.
#mycology #immunology #IDMastodon #Science #IL17 #Candida

cell.com/cell-host-microbe/ful

#introduction

Hi, everyone! We are an #Immunology research lab 💉🧪 🧬 🔬 📊 based at the University Hospital Bonn, Germany. We are also affiliated with the Cluster of Excellence #ImmunoSensation . Looking forward to discussing #Tcells #Tfh cells #Bcells #GerminalCenters #Immunity #Autoimmunity #Infection #Cancer and #CancerImmunotherapy on #Mastodon !

Hi all! I'm a postdoc, about to start my lab at Penn studying metabolic fluxes in tumor and immune cells! Also i like bad science puns!

Colleagues at our sister #journal Science Immunology are looking to #hire another #editor to join their team! Prior editorial experience is welcome but not required. #RemoteWork is an option. The #job advertisement can be found here:

bit.ly/NextSciImmEditor

#science #immunology #publishing #career

#introduction I’ve been reluctant to engage with yet another social media platform, but this seems as good as any to keep up with others’ #science, which I do enjoy!

I’m a #postdoc at Penn (Microbiology) working with @SunnyShinLab. My research interests include #immunometabolism, #InnateImmunity, and #HostDefense in the lung. I’m also passionate about #education, #mentorship, #MentalHealth, and #DEI in STEM.

When not in lab, I’m either running and/or listening to the latest hard rock album!

Show older
Qoto Mastodon

QOTO: Question Others to Teach Ourselves
An inclusive, Academic Freedom, instance
All cultures welcome.
Hate speech and harassment strictly forbidden.