Joram Mooiweer @JoramMooiweer@qoto.org

Hello👋 I’m a research fellow and psychiatrist at the University of Cambridge. I work on interactions between the immune system, brain and behaviour esp using #ImmunoGenetics approaches. Interested in #biomarker discovery in psychiatry. Looking forward to discussions on here! #genomics #immunopsychiatry #neuroscience #neuroimmunology #introduction

Hej there, our first mastodon post from #madrid !
Heading to Chile to give a talk at @asochin and @umayor!

In #Science (@sciencemagazine) this week, the Hanahan lab shows that the #RNA-binding protein #FMRP enables #tumors to evade being attacked by #CD8TCells. It does so by both suppressing #CCL17 & promoting #Tregs via #IL33 & #M2 #macrophages via #PROS1 & #ExtracellularVesicles!

https://bit.ly/Sci_abl7207

#CancerImmunology #RBP

My latest Clinical Pipeline column at #NatureMedicine is just out.

This was an interesting piece for me, to see what's going with drugs targeting #TGFbeta family molecules in a clinical setting, in this case an activin receptor 2a/IgG1 Fc domain fusion protein selectively mopping up ligands. The drug's been through trials in oncology, thalassemia & other conditions, but it looks like it had a good hit in pulmonary arterial #hypertension.

#ClinicalTrial

https://www.nature.com/articles/d41591-022-00109-w

#intro
Hello! I am a PhD student in System Biology at #UdeM. I am passionate about science and in love with #immunology
Bachelor in Biology-Genetics #ufrj
Masters in Oncology #inca (Brazilian National Cancer Institute),
I've been working on onco-immunology for 10 years. I started by improving CAR-T cell design, and in the last five years, I focused on understanding the tumor immune microenvironment using #scrnaseq #bioinfo

"Here we show that individual Bmp ligands and Tgfβ drive distinct enterocytic programs specific to villus zonation. Bmp4 is expressed mainly from the center to the upper part of the villus, and it activates preferentially genes connected to lipid uptake and metabolism. In contrast, Bmp2 is produced by villus-tip mesenchymal cells, and it influences the adhesive properties of villus-tip epithelial cells and the expression of immunomodulators."

#Immunology #MucosalImmunology #DevBio #Preprint

https://www.biorxiv.org/content/10.1101/2022.11.11.516138v1

Re #introduction

Hey everyone, I'm Prathyusha, a postdoc at Dana-Farber/Harvard Medical School. My PhD research was in #cancer #immunology and my current research interests are in #immunology and #genetics of #kidneycancer

I enjoy reading and painting as a hobby.

I mostly toot about science and occasionally you'll find random musings, food, and paintings (though life has been too busy lately to focus on the last).

Here to meet the fun #academic and #scientific community! #ScienceMastodon

Just getting set up on here. Looking forward to connecting with the #immunology #science mastodon community!

Nice study showing Candida albicans lipase suppressing host IL-17 responses & promotes invasive infection.

Caveats re model systems used, etc.. but interesting demonstration of pathogen evasion of protective host immune responses.
#mycology #immunology #IDMastodon #Science #IL17 #Candida

https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(22)00517-0#secsectitle0070

#introduction

Hi, everyone! We are an #Immunology research lab 💉🧪 🧬 🔬 📊 based at the University Hospital Bonn, Germany. We are also affiliated with the Cluster of Excellence #ImmunoSensation . Looking forward to discussing #Tcells #Tfh cells #Bcells #GerminalCenters #Immunity #Autoimmunity #Infection #Cancer and #CancerImmunotherapy on #Mastodon !

Hi all! I'm a postdoc, about to start my lab at Penn studying metabolic fluxes in tumor and immune cells! Also i like bad science puns!

Colleagues at our sister #journal Science Immunology are looking to #hire another #editor to join their team! Prior editorial experience is welcome but not required. #RemoteWork is an option. The #job advertisement can be found here:

bit.ly/NextSciImmEditor

#science #immunology #publishing #career

#introduction I’ve been reluctant to engage with yet another social media platform, but this seems as good as any to keep up with others’ #science, which I do enjoy!

I’m a #postdoc at Penn (Microbiology) working with @SunnyShinLab. My research interests include #immunometabolism, #InnateImmunity, and #HostDefense in the lung. I’m also passionate about #education, #mentorship, #MentalHealth, and #DEI in STEM.

When not in lab, I’m either running and/or listening to the latest hard rock album!

A key thing I've learned about Mastodon: When you find people you know and want to keep up with, don't just follow them — add them to a list!

Merely following is not enough, b/c their posts may not show up in your feed at a time you're logged on. Unlike FB or Twitter, Mastodon has no algorithm to resurface your friends' posts from hours or days ago.

So create a list called "Friends" and check it when you're on. This will ensure that you see what they posted while you were away.

#introduction

joining mastodon to discuss #science, #cardiology, #immunology, #immunocardiology, tissue repair, #aging, amongst other topics.

Welcome aboard!

@JeffMold

@ImmunoCardioLab

#Immunology

Tools for off- the-shelf CARTs:

"Conventional CRISPR-Cas nucleases install sequence-specific DNA double-strand breaks (DSBs), enabling gene knock-out (KO) or targeted transgene knock-in (KI). However, simultaneous DSBs provoke a high rate of genomic rearrangements which may impede the safety of the edited cells. Here, we combine a non-viral CRISPR-Cas9 nuclease-assisted KI and Cas9-derived base editing technology for DSB free KOs within a single intervention."

#CARTcells #Immunology #Immunotherapy #crispr #preprint

https://www.biorxiv.org/content/10.1101/2022.11.11.516008v1

POLL: If you've been on #Mastodon for over a week and used it each day, how likely are you to go back to using Twitter on a regular basis?

Boost for a larger sample size please.