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Nuclear tension controls mitotic entry by regulating cyclin B1 nuclear translocation 

"[...] a tension-dependent signal on the that sets the time for nuclear envelope permeabilization (NEP) and mitotic entry. This signal relies on , which unfolds the nucleus during the G2-M transition, activating the stretch-sensitive on the nuclear envelope and regulating the nuclear translocation of B1.[...]"
rupress.org/jcb/article-abstra

#ScienceSunday #ScienceMastodon

Ever wonder how flowers get their colors?

Anthocyanin pigments, stored in vacuoles of petal cells change color with pH (acidity). The Japanese Morning Glory Ipomoea tricolor var. Heavenly Blue, changes from purple-red to blue in the early hours of the morning. The pH change is caused by NHX1, a transport protein that replaces protons with sodium or potassium ions. Similar genes in humans are critical for function of neurons and other cells.

Ref: PMC3559195

A few years ago I made this flow chart of which Mastodon posts end up in which timelines!

So, you can see how each instance will have a different local timeline, and even a slightly different federated timeline - and you can see why the federated timeline moves so much faster than the local one, too.

This is why it's important to boost good posts and use hashtags - the fediverse is fragmented and harder to search by nature.

[ #mastodon #meta #tootorial #howto #mastopedia #mastotip ]

Hello, #Mastodon! Greetings from my hospital bed.

This image depicts blood vessels in a pigeon’s head. It was captured by the veterinarian Scott Echols as part of an ongoing endeavour known as the Grey Parrot Anatomy Project, which aims to develop ways to aid diagnosis and treatment for a host of animals, from birds to humans. By understanding what is normal, doctors and scientists are better positioned to identify and ultimately treat the abnormal. #sciart #ScienceMastodon #medicalhistory

Combinatorial interpretation of BMP and WNT allows BMP to act as a morphogen in time but not in concentration. 

"[...] varying the duration of leads to either pluripotent, mesodermal, and extraembryonic states, while varying the concentration does not cause efficient mesodermal differentiation at any dose [...] appropriately timed pulse of BMP induces to a mesodermal fate more efficiently that sustained signaling at any concentration. [...] this effect is due to a combinatorial interpretation of the applied BMP signal and induced endogenous signaling."
biorxiv.org/content/10.1101/20

#introduction

I’m a postdoctoral scientist studying #imageanalysis 🔬at the Broad Institute.

Interested in #opensource software for #biology, #dataviz (mostly with #RStats ), and #videogames 🎮👾.

I love using my expertise to help generate biological insights from data. 📊

Did you know?

Bumblebees used to be called Humblebees?

Back in Darwin's day and up to the early 20th century, they were mostly referred to as Humblebees due to the fact that they hummed while flying! But the lesser used named of Bumblebee existed on the fringes.

At some point between the two World Wars, there was a shift and Bumblebee became more popular and Humblebee was consigned to history.

This entry by A.W. Stelfox in the Irish Naturalist' Journal in 1921 still used the old name.

Want Mastodon to become more interesting?
1. Connect with other #DevBio #DevBiol peeps here.
2. Post. It’s up to us to start talking.
3. Tell us about who we should follow (not all accounts visible on the follow lists of others, if on different servers).

New people, welcome to Mastodon and the Fediverse!

Here's how to get started:

1. Find some people to follow over on @FediFollows, and through Trunk (communitywiki.org/trunk)

2. Find out your Mastodon/Fediverse address so you can share it with friends (mstdn.social/@feditips/1072482)

3. Invite people to join you on here by telling them to go to joinmastodon.org and click on "Get Started". It doesn't matter if they join a different server because the servers talk to each other (here's a bit more of an explanation mstdn.social/@feditips/1070214)

4. Find out what the Fediverse is (mstdn.social/@feditips/1070440)

5. Find out why Mastodon being on so many different servers/instances is a really good thing (mstdn.social/@feditips/1070837)

6. If you see anything nasty, you can report it to your friendly server admin (mstdn.social/@feditips/1065401)

7. You can (sort of) verify your account if you own a website (mstdn.social/@feditips/1062741)

If you have any questions, @ me or DM me!

#MastoTips #FediTips #Mastodon

Hello, I am a postdoctoral research associate at Robarts Research Institute, Canada.

I have been studying vascular biology, with a specialized focus on Aorta & muscle microvasculature, and broad interests in biomedical & biological sciences.

Currently writing up all viable projects in my generation Hopefully to be on the job market soon.

Nice to meet everyone on Mastodon

Hello #science Mastodon friends! I’m a postdoc at University of Geneva studying #membrane remodeling with #invitro #reconstitution cell biology tools. I love fluorescence #microscopy and #em. 
At the moment I’m actively studying #clathrin, #actin and #eisosome. I want to know more about membrane lipids and how they affect on membrane properties, protein functions and how membrane is deforming. #introduction

Watch this and try not to think about the space.
Congratulations @DInoueMT 💪🏼
---
RT @DInoueMT
After reading the paper, you will get some idea to understand why two different types of chiral patterns, i.e. monopolar rotational spiral and bipolar nematic pattern, emerge from gliding microtubules.
twitter.com/DInoueMT/status/15

Understanding a little bit more about the #fediverse through data. Here is a plot of all #fediverse instances at instances.social as a function of their number of users and toots (statuses) and if they are open for new accounts. In general, instances are small in the number of users (median = 28). Interestingly, there are a lot of small, very active, and closed servers in the #fediverse. Also, some of the biggest servers are Japanese communities.

#PhD students of #Mastodon, I have created a Mastadon group for sharing PhD-related posts using @phdstudents when posting a PhD student toot. Let's help the group to grow and share our PhD student experiences.

#Students #postgraduate #research #connectivity #PhDStudents

Hi, #ScienceMastodon! It's time for an #introduction. 👋

I'm a PhD candidate in the Tolić lab where I study cell division & aneuploidy using STED, LLS & confocal #microscopy. 🧬🔬

Here's a video of the cell with marked chromosomes and tubulin going through mitosis. Chromosomes are colored for depth.

Let’s start a thread with all our: #DevBio #DevBiol #science peeps. Please add more below to help us find everybody! Who are your DevBio friends? We need to post to make this place more vibrant:
@DenisDuboule
@opourquie
@mads100tist
@RogersLabUCD
@HaoYin
@scottbarolo
@kkroll
@SpagnoliLab
@Mill_lab
@jamesbriscoe
@MokalledLab
@AaronJohnson
@ebardot

Tools for off- the-shelf CARTs:

"Conventional CRISPR-Cas nucleases install sequence-specific DNA double-strand breaks (DSBs), enabling gene knock-out (KO) or targeted transgene knock-in (KI). However, simultaneous DSBs provoke a high rate of genomic rearrangements which may impede the safety of the edited cells. Here, we combine a non-viral CRISPR-Cas9 nuclease-assisted KI and Cas9-derived base editing technology for DSB free KOs within a single intervention."

biorxiv.org/content/10.1101/20

Short #introduction :
I'm a first year PhD student at #NetSI. Broadly interested in #ComplexSystems and #NetworkScience . Currently, I'm looking into #NetworkDynamics, #Emergence and #CollectiveBahavior from the perspective of #InformationTheory and #BayesianInference .

Eventhough it's not my main area of expertise, I love to read and learn about #EvolutionaryBiology, #DevelopmentalBiology and #SystemsBiology .

So now that I'm satisfied that I might be on #Mastodon #FediVerse for a while, here is my #introduction. I am computational biologist interested in protein function prediction, microbial #genome #evolution. Since #biology is now a #BigData #science, I am also looking into various #DataScience aspects of biological #data especially data #bias and #imbalance, and how these biases affect our understanding of #life.

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