Andrew Kennard @askennard@qoto.org

I'm excited to share that our team has a new opening for a Computational Biologist role at Invitae.

We are a highly cross-functional research team of computational, experimental and clinical scientists with a mandate to maximize the utility of genomic information by developing and validating new insights into the effect of genetic variants.

https://boards.greenhouse.io/invitae/jobs/4710235

#hiring #genomics

Beautiful #cryoET paper on choanoflagellate #flagella #cilia revealing the enigmatic ciliary vane, new components and similarities to animal cilia
#protist #evolution #EM #choanoflagellate
https://elifesciences.org/articles/78133

is it surprising that nucleotide analogs are good cancer drugs, but not (to my knowledge) ribosomal poisons or anti-protein synthesis drugs?

The NIH Advisory Committee to the Director is starting a working group on “Re-envisioning NIH-supported Postdoctoral Training.” Slide deck here has some data and details: https://acd.od.nih.gov/documents/presentations/11032022_ACD_Working_Group_Postdoc.pdf

What would you like them to know? What would you like them to do?

#Introduction: I am curious about how proteins and membranes work in cells to deliver cargos. Multidisciplinary lab (with great collaborators) at UMass Chan Medical School #MembraneTraffic #Biochemistry #StructuralBiology #CryoEM #Biophysics #CellBiology #Genetics #Immunology
Also passionate to increase diversity, equity, inclusion and belonging in #Science #Academia.

Way overdue, but #Biopython 1.80 is out https://pypi.org/project/biopython/1.80/ - expect formal announcement later https://mailman.open-bio.org/pipermail/biopython/2022-November/016950.html - conda packages soon too! Thank you to all the contributors

NEW BARTMAN LAB WEBSITE JUST DROPPED: https://bartmanlabpenn.squarespace.com/
Techs/staff scientists/postdocs/students, come work with us in 2023!
(pls retoot =)

Alright Mastodon let's do this.
#Introduction I'm Dr. Liz Haynes. You might know me as @actin_crazy on twitter. I'm a Morgridge post-doctoral researcher studying #neurodegeneration and #neurodevelopment using #zebrafish and #microscopes! I am all about #openaccess and #opensource solutions. I get to hang out with the cool folks working on ImageJ2 at the Laboratory for Optics and Computational Instrumentation (LOCI) at UW-Madison. Follow me for the pretty pictures, stay for the science!

@mikelove Post about papers, blogs and repos you are reading. What made Science Twitter useful for me a grad student was to put research in front of me from outside of my own citation graph, and provide some context for why someone would care about it.

Hi all! I'm a postdoc, about to start my lab at Penn studying metabolic fluxes in tumor and immune cells! Also i like bad science puns!

I am wondering if anyone has experience in doing comparative analysis of #scRNAseq datasets from different species, or if anyone knows of good resources about that esp with an #evolutionaryBiology focus?

#biology #sequencing #bioinformatics

"The controlled expression of one cellular feature -- the cilium -- was likely critical during early animal evolution. Two key transcription factors, RFX and FoxJ1, coordinate ciliogenesis in animals but are absent from the genomes of most other ciliated eukaryotes, raising the question of how the transcriptional regulation of ciliogenesis has evolved."

#CellBiology #CIlia #evolution #Preprint

https://www.biorxiv.org/content/10.1101/2022.11.11.515474v1

A cell photographed through a microscope. DNA in the nucleus, the Golgi apparatus, and actin filaments are shown. This is from my colorblast series in which I cycle an image through the spectrum. Our eyes see some colors better than others, so the effect gives the impression of ever-changing perspectives from a still image; and it’s pretty. #cellbiology #sciart

Sarcomeres assembling in an immature heart muscle cell videoed through a microscope. A protein that localizes to “Z lines” and their precursors “Z bodies” is shown. If you look carefully you can see the Z bodies concatenating into Z lines. Unless this GiF does not upload. In that case you will just see Z bodies sitting there and I will continue to work on posting here. #cellbiology

Another design consideration re: Mastodon is that it works well for ephemeral asynchronous communications, but for many reasons should not be counted on as an archival resource. Media attachments are periodically purged and may not be available after a week, or a month, etc. While some servers may try to preserve content forever, this may be costly and unsustainable. Creators, researchers should treat this as an ephemeral resource and make provisions for self-archiving anything important.

I'm very fortunate to be a co-organiser of "Dynamic Cell V", the latest in the Biochemical Society and BSCB meeting series showcasing the activity of living cells from all kingdoms of life. The details are: 17 to the 20 April 2023, Loughborough University (UK). Registration will open at https://biochemistry.org/events/dynamic-cell-v/