Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
"The rabbits’ “interracial” union had inflamed Montgomery's chapter of the White Citizens’ Council, whose members argued that the book amounted to grooming by literary means, conditioning preschoolers to cross the color line. Essentially a white-supremacist chamber of commerce, with a fast-growing network across the South in the wake of the U.S. Supreme Court’s Brown v. Board of Education desegregation decision in 1954, the council used its dollars and clout to stoke economic intimidation and violence against the burgeoning civil rights movement. These segregationists were ideological ancestors of today’s book challengers, such as those in a Florida school district that recently banned “And Tango Makes Three,” about two male chinstrap penguins who create a family. Across time, those who ban books have shared a deep aversion to anything that promotes changing definitions of marriage and family."
https://www.nytimes.com/2023/04/26/books/review/garth-williams-the-rabbits-wedding-banned-books.html
"Map 11 The Two Ladies (Leiden, Netherlands, circa 1790)
The Two Ladies is a direct reaction to the vision of medicine put forward by the Encyclopedists, particularly in d’Alambert’s treatise on the primacy of sensory knowledge and experimentation, the Discours préliminaire. The two female figures are a not-even-thinly veiled insult directed at Diderot & d'Alembert (it was a time of rampant misogyny and Dutch humor remains to this day, as they say, no laughing matter). The image is not a map but rather a chart of sorts, with texts of Galen’s prescribed treatments overlaid on the corresponding afflicted body parts. The Margrave brought a copy of this print with him to Kaiserslautern in 1933, but it is not known if Galen’s typology of human temperament played any part in von Willebrand’s course of treatment."
#Prints #Printmaking #Print #Handmade #Maps #Cartography #artgallery #artmastodon
Tools:
"Here we show that the yields of edited primary human lymphocytes can be increased substantially by delivering a CRISPR ribonucleoprotein mixed with an amphiphilic peptide identified through screening. We evaluated the performance of this simple delivery method by knocking out genes in T cells, B cells and natural killer cells via the delivery of Cas9 or Cas12a ribonucleoproteins or an adenine base editor."
#CRISPR #crisprcas9 #geneediting
'In this study, we report that high CDK6 expression positively correlates with immunotherapy resistance in 6 of 7 single-agent immunotherapy clinical studies for melanoma patients. CDK6 depletion, but not that of CDK4, cyclin D1, or D2, in cells of the TME inhibits tumor growth.'
#immunotherapy #immunology
https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00325-X
"It was only toward the middle of the twentieth century that the inhabitants of many European countries came, in general unpleasantly, to the realization that their fate could be influenced directly by intricate and abstruse books of philosophy."
Czeslaw Milosz, The Captive Mind.
'In this review, we focus on systems-level methods of immunometabolism that connect immune (and nonimmune) cells in tissues via metabolic communications and reveal cellular and functional heterogeneity of immunometabolic circuits.'
#Immunology #Metabolism
https://www.annualreviews.org/doi/full/10.1146/annurev-immunol-101220-031513
Aquatint & chine-collé with colours added through viscosity printing by @madparreira
https://madalenaparreira.com/Aquatints
#Prints #Printmaking #Print #artofinstagram #Aquatint
#Handmade #chinecollé #artmastodon
The FDA has approved Biogen's ALS drug, Tofersen, an antisense oligo targeting SOD1. I wrote about this back in September in my Clinical Pipeline column as part of a shift towards approving drugs based on biomarkers without clear signs of clinical efficacy*.
https://www.nature.com/articles/d41591-022-00098-w
*You can have a look at the trial data in NEJM, in a study that concluded that "In persons with SOD1 ALS, tofersen reduced concentrations of SOD1 in CSF and of neurofilament light chains in plasma over 28 weeks but did not improve clinical end points and was associated with adverse events."
#NatureMedicine #amyotrophiclateralsclerosis #drugdevelopment #pharma
From Andersen-Nissen et al, PNAS 2005.
"We map the site responsible for TLR5 evasion to amino acids 89-96 of the N-terminal D1 domain, which is centrally positioned within the previously defined TLR5 recognition site. Salmonella flagellin is strongly recognized by TLR5, but mutating residues 89-96 to the corresponding H. pylori flaA sequence abolishes TLR5 recognition and also destroys bacterial motility."
'Flagella-driven motility is essential for the entry of H. pylori into the mucus layer and for maintaining a swimming reservoir in the mucus (Fig. 3). H. pylori has a unipolar bundle of rotating sheathed flagella, with filaments composed of two flagellin proteins that evade activating the innate immune system via TLR5 due to specific adaptation of their amino acid sequences'
'In this review, we will briefly introduce the current treatment paradigms for PDAC and then expand upon the biological underpinnings driving its pathogenesis and progression.'
My latest Clinical Pipeline column for #NatureMedicine, on fitusiran, a small interfering RNA for the treatment of hemophilia A or B. It may be particularly useful for patients with inhibitors (antibodies against clotting factors).
#drugdevelopment #drugdiscovery #SciComm #sciencecommunication #pharma #hemophilia 👇
Frogs, glazed #stoneware by @hunchbacksociety
Richard Avedon and James Baldwin in Harlem, 15 October 1946 © Photograph by Richard Avedon © The Richard Avedon Foundation
https://www.ft.com/content/62a017eb-0ab6-449f-9d06-646c0bd42bc4
Neutrophil BM shuttle:
"We demonstrate how drug-loaded poly(lactic-co-glycolic acid) nanoparticles are taken up by neutrophils and are then transported across the bone marrow–blood barrier to boost drug concentrations in the bone marrow."
Not the BBC's finest hour (from The British Broadcasting Conundrum by Matt Seaton in NY Review of Books).
#newyorkreviewofbooks #bookshelf
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
