Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'When Professor Harald zur Hausen, who has died aged 87, identified a link between the human papillomavirus and cervical cancer almost half a century ago, few of his fellow scientists took the breakthrough seriously.'
https://www.ft.com/content/eeb66a36-29e4-4a14-b7a4-0ca59214ad05
Bairrada is a very underrated wine region of Portugal. They make wonderful dry sparkling like this one.
cc @BLMG
Gene therapy with AAV vectored micro-dystrophin for Duchenne muscular dystrophy. My latest #ClinicalPipeline column for #NatureMedicine.
Cool line up for this brain #organoid course at CRG-Barcelona, but too bad they could not get Dr. Michael Hfuhruhurr.
https://www.crg.eu/en/event/coursescrg-brain-organoids-advanced-hands-course-2023
"Our investigation reveals that the fetal HSCs respond to T. gondii infection with virulence-dependent changes in proliferation, self-renewal potential, and lineage output. Furthermore, maternal IFNγ crosses the fetal–maternal interface, where it is perceived by fetal HSCs."
'The cGAS-STING pathway has long been recognized as playing a crucial role in immune surveillance and tumor suppression. Here, we show that when the pathway is activated in a cancer-cell-autonomous response manner, it confers drug resistance.'
https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(23)00141-1
'Old and newly synthesized histones are asymmetrically distributed and inherited in Drosophila intestinal stem cell divisions. Disruption of asymmetric histone inheritance compromises stem cell differentiation, indicating a role in regulating cell fates in adult stem lineages in vivo.'
'What particularly impressed Tolstoy’s contemporaries was his seemingly superhuman ability to trace Prince Andrei’s thoughts after he loses the ability to communicate with others. “How does Count Tolstoy know [all] this?” asked the novelist Konstantin Leontiev. “He did not rise from the dead and visit us after his resurrection.” And yet he convinces readers that, yes, it could really be just this way.'
https://www.nybooks.com/articles/2023/06/22/death-and-the-hedgehog-tolstoy-as-philosopher/
IL6 is not always the bad guy.
"In the penumbrae of human stroke brain lesions, we identified a subpopulation of microglia that express vascular endothelial growth factor A. These cells, termed ‘repair-associated microglia’ (RAMs), were also observed in a rodent model of CVI and coexpressed interleukin (IL)-6Ra. Cerebrovascular repair did not occur in IL-6 knockouts or in mice lacking microglial IL-6Ra expression"
#Immunology #Inflammation #Microglia #Neuroimmunology
If you will be in Lisbon on June 16th
'Here, we show that yeast paralogous genes are more divergent in transcription than in translation. We explore two causal mechanisms for this predominance of transcriptional divergence: an evolutionary trade-off between the precision and economy of gene expression and a larger mutational target size for transcription.'
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010756
"To watch Bruce Springsteen step onto a stage in New Jersey is to watch Moses walk to the edge of the Red Sea, so confident in his ability to perform a miracle, to carry his people to the Promised Land."
#HanifAbdurraqib #Book #Bookclub #Reader #Bookshelf #MusicBooks #bookstodon
Cholesterol & anti tumor T cell immunity:
"We analyze the cholesterol atlas in the tumor microenvironment and find that intratumoral T cells have cholesterol deficiency, while immunosuppressive myeloid cells and tumor cells display cholesterol abundance. Low cholesterol levels inhibit T cell proliferation and cause autophagy-mediated apoptosis, particularly for cytotoxic T cells"
#Immunology #immunotherapy #immunooncology #CancerImmunity
https://www.sciencedirect.com/science/article/abs/pii/S1535610823001423?via%3Dihub
Wolf lamp, could be Roman, but is by @hunchbacksociety
#ceramics #stoneware #handmade #artgallery #ceramic #artmastodon
https://madalenaparreira.com/Hunchbacksociety
If you like the #handmade #ceramics #stoneware from @hunchbacksociety and are in Lisbon today (Saturday) visit 👇
FEIRA DA FRUTEIRA
Curadoria de FELIPA ALMEIDA
26 & 27 Maio
12h - 19h
Campo de Ourique.
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
