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"To prepare for future outbreaks, the disease-modeling community can improve their modeling capabilities by learning from the methods and insights from another arena where accurate modeling is paramount: the weather and climate research field."
cc @gregggonsalves @lmrocha

pnas.org/doi/10.1073/pnas.2209

On the Tejo with Madalena, back when it wasn't raining every *%$ day

"However, despite deep knowledge about the genomic drivers of cancer—from oncogenic mutations to chromosomal rearrangements—we do not yet know how the spatial arrangement of the tumor microenvironment (TME) impacts pathogenesis; for instance, which feature types and spatial scales are relevant, how disease-associated histological features relate to molecular states, and whether morphological differences are discrete (like mutations) or continuous (like morphogen gradients)."

sciencedirect.com/science/arti

'From this situation, one must act, and transcend those boundaries. This ‘living process’ (‘lebendige Prozeß’) involves casting off the worldview that you have come to the limits of, and creating another. Much like a hermit crab, a worldview is a shell that we enclose and encase ourselves within. That shell then insulates us from experiences that challenge our worldview. The task of psychology is to engage with this tendency in human nature, and bring the subject out of these shells (‘Gehäuse’).'

aeon.co/essays/karl-jaspers-th

"This study reveals how CD4+ T-cell help optimizes human cDC1 function for inducing a CTL response against cancer cells, which provides strong arguments to engage CD4+ T-cell help in cancer immunotherapy."

nature.com/articles/s41467-022

"If the bloodied man at Hennepin had arrived a day earlier, he might have died while his doctors continued to monitor him. But he had stumbled into an experiment. A small group of Hennepin doctors had decided to place an ultrasound machine in the E.R.’s trauma bay, to see if they could quickly diagnose hemorrhaging in the heart."

newyorker.com/science/annals-o

"Pierre Verger was born in Paris in 1902, as a wild child of the haute bourgeoisie, and died in 1996 in Salvador, Bahia, Brazil, as Pierre Fatumbi Verger, a revered elder of the Candomblé sect. In between, he lived like a nomad, like a man on the run, tracing and retracing the paths of the African diaspora and somehow managing to publish thirty books and make countless photographs, many of which were lost along the way."

newyorker.com/culture/photo-bo

AJ Liebling was not impressed by Proust.
(Fm The Library of America's "The Sweet Science and Other Writings).

'Elsewhere, dozens of jaw bones are stacked up. One lower jaw of a male sperm whale is abnormally twisted into a corkscrew shape: this unusual specimen came from an Antarctic whaling ship in 1959. At first glance, the jaw seems to make feeding an impossibility. But the back teeth, worn down to “stumpy pegs”, indicate that this whale was successfully eating giant squid, thanks to its highly specialised echolocation and efficient suction feeding.'

theguardian.com/environment/20

An illustration that Madalena Parreira made for an interview I did with Leonard Zon for the now defunct JEM blog "Dr Flexner's Suitcase".
madalenaparreira.com

"Microbiolatry".
Spoiler alert: Pasteur won the bet.

From Wasik & Murpy's book on the history of rabies, the aptly named "Rabid".

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