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Personalized RNA for advance to phase III trials (in combination with anti-PD1). My latest Clinical Pipeline column for
@NatureMedicine

nature.com/articles/d41591-023

"When leptin failed, he tried a different gut hormone, ghrelin, whose effects were the opposite of leptin’s. The more ghrelin an animal had, the more it would eat. Perhaps a drug that blocked ghrelin would make people lose weight.

“Again, it wasn’t that simple,” said Dr. Tschöp, who left Lilly in 2002."

nytimes.com/2023/08/17/health/

I discussed the origin of these new diabetes and weight loss drugs with Matthias, you can listen to "Obesity is a Brain Disease" scrolling down at the link below.

pioneercampus.org

'Our much loved Microbe Art Contest is coming back again this year to support International Microorganism Day on 17 September 2023! Help celebrate the wondrous world of microbes by getting creative and sharing your art! '

fems-microbiology.org/microbe-

Personalized RNA for advance to phase III trials (in combination with anti-PD1).
My latest Clinical Pipeline column for @NatureMedicine
nature.com/articles/d41591-023

It positively glows with marital bliss

"Yet Jakob Fugger and Sybilla Artzt were man and wife. This painting, by the German artist Hans Burgkmair the Elder, was made to commemorate their wedding in 1498."

ft.com/content/3dbc2126-04eb-4

'We have identified a neural circuit for innate male sexual behavior (Figure 7U). This circuit enables recognition of potential mates and motor displays of mating, rejuvenates sexual drive, and makes mating rewarding. Moreover, our findings show that the brain employs distinct neural circuits to generate male mating and aggression.'

cell.com/cell/fulltext/S0092-8

Não vá se afobar
Não tem que pôr a mesa, nem dá lugar

'Fifty years ago this month, the best-selling novel and the best-selling nonfiction title in the country had something unusual in common: They were both illustrated.'

nytimes.com/2023/08/10/books/r

"Here, we show that key metabolic functions of human hepatocytes are controlled by non-parenchymal cells (NPCs) in their microenvironment. We developed mice bearing human hepatic tissue composed of human hepatocytes and NPCs, including human immune, endothelial, and stellate cells. "

cell.com/cell/fulltext/S0092-8

Word of the day: "If the traveller had scaled the peak of phonolithic rock - so called because of the xylophonic sound the stones make as they slide away under a climber's feet (...)"

Graham Robb, The Discovery of France.

It's early & I haven't had coffee yet, but bear with me: is it conceivable that the Roberts Court has done the right thing?

"US Supreme Court halts $6bn Purdue opioid settlement in blow to Sacklers"

ft.com/content/5af08faf-1b87-4

"Maps 12 & 15 von Willebrand Collection Vault map (12) and inset (15) (Dresden, Germany, 1919?).

(...) von Willebrand lived to the age of 97, finally expiring at a spa outside of Kaiserslautern, an obscure minor nobleman who never escaped his internal exile to the provinces. He died in the same year as the Weimar Republic, in 1933. The Margrave’s ill-advised attempt to keep up with the times led to the von Willebrand vault map’s misidentification as Degenerate Art. As a result, almost all copies were destroyed by the newly established Reich Chamber of Culture. Only the original copper plate matrix of the vault map remained untouched in the Sophienkirche annex, together with a pair of printed copies. The church was comprehensively destroyed during the Allied bombing of Dresden in 1945. Incredibly, a controlled detonation of unexploded ordinance in the immediate postwar period led to the unearthing of the vault map plate and a pair of prints in pristine condition"

madalenaparreira.com/SPAM

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