Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'While moving upwards the intestinal villi enterocytes acquire different cellular fates, which is promoted by a gradient of Bmp ligands. In addition to this gradient individual Bmps have distinct activities in the differentiation of enterocytes.'
Berková et al @emboreports
''Lymph nodes (LNs) are critical sites for shaping tissue-specific adaptive immunity. However, the impact of LN sharing between multiple organs on such tailoring is less understood. Here, we describe the drainage hierarchy of the pancreas, liver, and the upper small intestine (duodenum) into three murine LNs.''
https://www.cell.com/immunity/fulltext/S1074-7613(23)00321-7
"They have investigated the brains of ageing mice, elucidating the source of the cGAS–STING trigger and the particular cells in which this pathway is activated (Fig. 1). Specifically, the authors find that cytosolic DNA derived from perturbed mitochondria activates the pathway in ageing microglia, the main immune cells in the brain — an observation that agrees with earlier findings that cGAS–STING is involved in activating microglia and in neuroinflammation"
#Immunology #Neuroimmunology #NeurodegenerativeDisease #InnateImmunity
'In contrast to the pathological activation of the immune system by metabolic stress, little attention has been paid to the physiological role of the immune system in regulating energy supply. In fact, the primary function of the immune system is to ensure tissue integrity and repair, thereby maintaining homeostasis.'
#Immunology & #Metabolism
https://www.cell.com/trends/immunology/fulltext/S1471-4906(23)00110-2
Benchmarking scATAC-seq
"Hence, an unbiased comparison of the use of different scATAC-seq methods on reference samples, and the resulting ‘benchmark data’, will allow researchers to make an informed method selection when considering scATAC-seq. Our study aimed to reduce ‘information asymmetry’ by equipping researchers with a comprehensive benchmarking of scATAC-seq tools, to increase the quality of data while reducing costs through informed decision-making."
"The Food and Drug Administration on Friday approved the first pill for postpartum depression, a milestone considered likely to increase recognition and treatment of a debilitating condition that afflicts about a half-million women in the United States every year."
https://www.nytimes.com/2023/08/04/health/postpartum-depression-pill-fda.html?action=click&module=Well&pgtype=Homepage§ion=Health
In April I wrote about how this new class of drugs were developed for #NatureMedicine. Read it at the link below:
'These findings suggest that an ancestral cRFXa homolog coordinated #ciliogenesis in the progenitors of animals and #choanoflagellates and that the selective deployment of the RFX regulatory module may have been necessary to differentiate ciliated from non-ciliated cell types during early animal evolution.'
#Evolution #CellBiology
https://www.cell.com/current-biology/fulltext/S0960-9822(23)00929-6
'While extensive research has focused on mitochondrial dNTP homeostasis due to its defects being associated with various mitochondrial DNA (mtDNA) depletion and deletion syndromes, the investigation of mitochondrial rNTP homeostasis has received relatively little attention.'
#mitochondria
"This series consists of three-dimensional and collapsable (pop-up) collages, made inside cardboard boxes. The images used are engravings and illustrations found in a german encyclopedia published in the 1930’s.
Scales range from 15cmx21cm to 21x28cm."
It's summer in Portugal, so we are required by law to grill sardines.
I hate to contradict Chuck D & Terminator X, but *do* believe the hype. Octavia Butler is an amazing writer. This one is Toni Morrison by way of Philip K Dick. #Books #Book #Bookshelf #bookstodon
Location location location
"Here, we show that NET1 mRNA location in combination with the rate of its translation can influence the ability of competing domains to determine the targeting of the newly synthesized protein, by favoring binding to specific partners. This RNA-based partner-selection mechanism provides a robust means of controlling protein function."
#MolecularBiology #Translation #RNA
Toto, I've a feeling we're not in New York anymore.
Cork, right after the harvest.
"A worker sleeps on a cart full of chickens at a wholesale poultry market in Mumbai, August 2010. Photograph: Danish Siddiqui/Reuters”
'For example, loss of function of the microglial gene Trem2 renders microglia dysfunctional and causes an early-onset neurodegenerative syndrome, and Trem2 variants are among the strongest genetic risk factors for AD. Thus, restoring microglial function represents a rational therapeutic approach. Here, we show that systemic hematopoietic cell transplantation followed by enhancement of microglia replacement restores microglial function in a Trem2 mutant mouse model of AD.'
#Alzheimer #NeurodegenerativeDisease #Microglia #Neuroimmunology
https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(23)00251-5#%20
"This series of prints was created between 2017 and 2021 and consists of several aquatints of stages, doors, caves or forests, where figures have been inserted through the technique of chine-collé, and colours added through viscosity printing."
#print #Printmaking #prints #printmaker #Aquatint #artgallery #artmastodon
'In a scattered show, the eye gravitates to the mysteriously poetic, as in a photographic series of Central American and Mexican ruins by the Argentine artist Leandro Katz. Katz retraced the travels of British artist-explorer Frederick Catherwood, who in the 19th century made exquisite drawings of ancient Mayan cities and published them for an exotica-obsessed audience back home.'
https://www.ft.com/content/8f7b9774-8112-46b0-b097-395c4ac388b9
“Developing a structure is seldom that simple. Almost always there is considerable tension between chronology and theme, and chronology traditionally wins. The narrative wants to move from point to point through time, while topics that have arisen now and again across someone’s life cry out to be collected. They want to draw themselves together in a single body, in the way that salt does underground. But chronology usually dominates. On tablets in Babylonia, most pieces were written that way, and nearly all pieces are written that way now.”
- John McPhee, Draft No. 4
"The effects of climate change driven by human activity are now part of the daily news cycle, and time is running out for decisive action."
Lab & academia's responsibilities in the climate emergency. A privilege to collaborate with @mucida & Rachel on this Nature Immunology commentary.
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
