Thiago Carvalho @cyrilpedia@qoto.org

You'll never guess what happened next...

"The key patent on the best-selling anti-inflammatory medication, used to treat conditions like arthritis, was expiring at the end of the year. Regulators had blessed a rival version of the drug, and more copycats were close behind. The onset of competition seemed likely to push down the medication’s $50,000-a-year list price."

#TNF #RheumatoidArthritis #lupus #PublicHealth #Humira #MonoclonalAntibody

https://www.nytimes.com/2023/01/28/business/humira-abbvie-monopoly.html

@Rumpelstiltskin@mastodon.nz @lrb Thanks for the feedback, I need to get it

If the NHS were on any more precipices, it would be Wile E. Coyote.

'The peers sent the findings of their inquiry into academic medicine to Steve Barclay, the health secretary, on Thursday, warning that “the clinical research environment in the NHS is on a dangerous precipice”.

https://www.ft.com/content/b5b9fe7f-7169-4ae6-a97b-cd98fe346ffe

"In a multinational, phase 3, head-to-head trial, ibrutinib, a Bruton’s tyrosine kinase (BTK) inhibitor, was compared with zanubrutinib, a BTK inhibitor with greater specificity, as treatment for relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL)"

#Leukemia #TyrosineKinase #BTKInhibitor

https://www.nejm.org/doi/full/10.1056/NEJMoa2211582?query=featured_home

@gpollara Particularly cool that in this case the anti-IFN abs may be having a beneficial effect, immune regulation by auto antibodies.

@yurivazu @CoriBargmann

Thank you

@clive cc @lmrocha

Alfama

"We report that out of 501 patients with SLE analyzed, 73 (14%) present autoantibodies against IFNα (anti-IFN-Abs). The presence of neutralizing-anti-IFN-Abs in 4.2% of patients inversely correlates with low circulating IFNα protein levels, inhibition of IFN-I downstream gene signatures, and inactive global disease score."

#Immunology #Lupus #Interferon #AutoAntibodies

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00473-6

'The Stasi and the censors never felt that they had really understood Neumann’s novels or deciphered what he was saying in them. Their training assured them that all creative writing conveyed a sociopolitical message, and they suspected that Neumann’s message—hidden in cryptic prose crammed with strange allusions and enigmatic comments—was a hostile one. But they never decoded it. This was because there wasn’t any message. Neumann’s fiction was certainly opaque, but the truth was that the literary sentinels of the GDR were stupid—sometimes comically so.'

https://www.nybooks.com/articles/2023/02/09/sonnets-for-the-state-stasi-poetry-circle-oltermann/

'To provide a comprehensive analysis of somatic mutations in the normal small intestine epithelium, we used the laser capture microdissection microscopy (LCM) and whole-genome sequenced 342 individual small intestine crypts from 39 individuals (173 duodenal from 22 individuals, 47 jejunal from 5 and 122 ileal from 16) aged between 4 and 82 years. Six had a history of celiac disease (gluten enteropathy).'

https://www.nature.com/articles/s41588-022-01296-5#Sec11

"The team hypothesised that some of the T cells specific to SARS-CoV-2 had been activated by a herpesvirus called human #cytomegalovirus (HCMV). This pathogen is highly prevalent in the population and has also been linked to changes in the severity of #COVID19 symptoms (Alanio et al., 2022). To investigate, they stimulated pre-pandemic blood samples with different segments of SARS-CoV-2 proteins. This led them to discover a population of ‘cross-reactive’ CD4 and CD8 T cells that can recognize epitopes from both #SARSCoV2 and #HCMV"

https://elifesciences.org/articles/85080?utm_source=mastodon&utm_medium=social&utm_campaign=organic_insights