Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
RT @_kamilruzicka
Are your splice isoforms evolutionarily conserved? A joy to work with a talented duo Ksenia Timofeyenko-Dima Konovalov, backed up by Maria Kalyna. Check some unexpected aspects of the evolution of plant (and animal) alternative splicing on:
https://nph.onlinelibrary.wiley.com/doi/abs/10.1111/nph.18799
Exhaustion, the early steps.
"Here, we performed single-cell RNA-sequencing and single-cell ATAC-sequencing of CD8+ T cells responding to LCMV-Armstrong (LCMV-Arm) or LCMV-Clone 13 (LCMV-Cl13), which result in acute or chronic infections, respectively."
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001983
Thiago Carvalho
boosted
New publication! We argue for an overhaul of academic systems to improve research quality: short-term employment, biased selection procedures + misaligned incentives hinder progress & rigor in research. #OpenScience #academia #IchBinHanna rdcu.be/c5brE
The paper is free to read via this link: rdcu.be/c5brE
Thiago Carvalho
boosted
Important editorial in @ScienceMagazine by Malcolm & Parikh; it's US-focused but the situation is similar everywhere.
Students and postdocs deserve more https://www.science.org/doi/10.1126/science.adh0336#.Y-XkYgSUemo.twitter
"TREX1 normally degrades cytoplasmic DNA to prevent inappropriate innate immune activation by self DNA. Our mechanistic studies revealed that this same process functions during #influenza virus infection to enhance replication."
#immunology #Virology #InnateImmunity #Preprint #Trex1
https://www.biorxiv.org/content/10.1101/2023.02.07.527556v1?med=mas
Thiago Carvalho
boosted
The #Antibiotic Resistance Crisis Has a Troubling Twist | WIRED
#amr
https://www.wired.com/story/the-antibiotic-resistance-crisis-has-a-troubling-twist/
Thiago Carvalho
boosted
Absolutely the best Acknowledgments section of a paper I’ve read. From https://arxiv.org/abs/2302.03988 / h/t @playingwithdust
Thiago Carvalho
boosted
How to be an academic in a world on fire?
As scientists concerned about the climate crisis, @clarekelly and I set out to rethink the role and goals of the university in tackling the 21st century's challenges. Inspired by Raworth's Doughnut Economics, we propose seven new ways to thinking - not only to help us think, but also to act.
Read the paper: Urai AE, Kelly C (2023) Rethinking academia in a time of climate crisis. eLife 12:e84991. https://doi.org/10.7554/eLife.84991
Join us for a discussion at Growing Up in Science Global on 11 April: https://nyu.zoom.us/meeting/register/tJIoc-GsqT8uGNXniBIHPo9u4ibfDwxysLkI
... and let us know your thoughts!
"Accurate prediction of TCR–antigen specificity can be described as deriving computational solutions to two related problems: first, given a TCR of unknown antigen specificity, which antigen–MHC complexes is it most likely to bind; and second, given an antigen–MHC complex, which are the most likely cognate TCRs?"
'Gefitinib (GF), the tyrosine kinase inhibitor (TKI) targeting epidermal growth factor receptor, initiates lung #inflammation through the NLR family pyrin domain containing 3 (NLRP3) inflammasome. However, the molecular targets and mechanisms underlying the inflammatory action of GF remain unknown. In this study, we identified mitochondrial Src family kinases (mSFKs) as key determinants of GF-induced #NLRP3 #inflammasome activation.'
"Scientists and artists are both motivated by creativity and curiosity, and science and art can be mutually reinforcing, supporting discovery and innovation. This Community Page highlights resources for individuals, groups, and institutions to advance science–art collaborations."
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001992
Thiago Carvalho
boosted
The inside of a cello looks like a place where something whimsically unspeakable happened in a Guillermo del Toro movie
Thiago Carvalho
boosted
Postdoc in B cell Immunology (Germinal centers, Bannard lab), Oxford.
Come join us #Postdoc B Cells, #Postdoc germinal centers, Oxford.
#ScienceJobs #job #Postdoc germinal centers
Oxford #UnitedKingdomUK #PostdoctoralFel...
https://jobrxiv.org/job/university-of-oxford-27778-postdoc-in-b-cell-immunology-germinal-centers-bannard-lab-oxford/?feed_id=37208
Thiago Carvalho
boosted
Join Cedric. He is fun and nice
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RT @CedricBardyLab
New Postdoc positions in my lab in Australia! Contribute to translational neuroscience with cutting-edge human brain tissue analysis. Looking for talented people with skills in electrophysiology, bioinformatics, computer programming OR stem cells. http://www.bardylab.com 1/2
https://twitter.com/CedricBardyLab/status/1623548740299812867
"Here, we report on the analysis of two independent cohorts of vaccinated health care workers, who developed an increase in anti-spike IgG4 antibodies and IgG4-switched memory B cells 5 to 7 months after the second mRNA immunization with Comirnaty."
Thiago Carvalho
boosted
Our analysis of Italian and US newspaper reporting on research about COVID-19 show some bubbles, plus Italian newspapers seldom provide a link to the scientific study they are writing about. (preprint) https://osf.io/preprints/socarxiv/dp849/
@rdrighetto Stick around Ricardo - twitter was super glitchy in the beginning. Let's make this place work.
Para quem nao sabe ler entre as linhas: o Moedas esta a dizer aos eleitores do Chaga, "nos temos os mesmos valores que voces, mas nao queremos assustar as tias da Garret".
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
