Thiago Carvalho @cyrilpedia@qoto.org

'We further demonstrated that cGAS mediated inflammation by acting as a macrophage polarization switch, which promoted peritoneal macrophages and the bone marrow–derived macrophages to the inflammatory phenotype (M1) via the mitochondrial DNA–mTORC1 pathway.'

#immunology #InnateImmunity

https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2200351/263495/cGAS-Mediates-Inflammation-by-Polarizing?redirectedFrom=fulltext

@donas170217@nrw.social @TheStrugglingScientists I friend & I actually made inquiries into an abandoned movie theatre we used to go to, the idea was bookstore, bar & classic movies (it was a big space). The owner told us they'd just sold it to a gym :(

'No “manifesto fundador” que a plataforma Universidade Comum lança neste fim-de-semana, o grupo nota que “a denominada modernização do sector foi ensaiada com a inscrição da lógica de utilizador-pagador no caso da implementação da política de propinas, o aumento da produção científica foi alicerçado em trabalho precário altamente especializado e a governação das instituições substituiu os modelos democráticos pela lógica empresarial”.

https://www.publico.pt/2023/03/04/sociedade/noticia/academicos-alunos-lancam-plataforma-logica-empresarial-universidades-2041029

"Over nearly three decades, for example, Lilly has raised the list price on its most widely used insulin product, Humalog, by more than 1,000 percent."

https://www.nytimes.com/2023/03/01/business/insulin-price-cap-eli-lilly.html

Lethal illiteracy

'His subsequent calculations leave him baffled as to why the UK has already experienced more deaths than his incorrect figure would suggest – even if everyone in the country were to be infected. The chief scientific adviser, Patrick Vallance, patiently explains the difference “It seems that the FT figure is 0.04 (ie 4% not 0.04%)”, to which Johnson replies: “Eh? So what is 0.04 if it is not a percentage?”

https://www.theguardian.com/commentisfree/2023/mar/03/boris-johnson-science-covid-maths-whatapps-advisers

"As with many of Britain’s social ills, the architecture of today’s care system is a product of Thatcherism, essentially unaltered by the Blair administration: an archipelago of small firms, each owning a single care home, alongside huge chains backed by venture capital. Long-term NHS geriatric beds are gone, and local authority homes have almost vanished."

https://www.lrb.co.uk/the-paper/v45/n05/james-butler/this-concerns-everyone

@dmaseda My mother makes Sarah Connor look like a deadbeat dad.

An antibacterial peptide encoded in the mitochondrial genome (#preprint).
#immunology #InnateImmunity

"We demonstrate that MOTS-c (mitochondrial open reading frame from the twelve S rRNA type-c) is a mitochondrial-encoded amphipathic and cationic peptide with direct antibacterial and immunomodulatory functions, consistent with the peptide chemistry and functions of known HDPs."

https://www.biorxiv.org/content/10.1101/2023.03.02.530691v1

"Here, we report that a high sugar diet reduces Drosophila female fertility by increasing death of early germline cysts (prior to follicle formation) and degeneration of vitellogenic follicles; that obesity in and of itself does not impair fertility; and that high glucose levels closely correlate with reduced fertility on a high sugar diet."

#preprint #Drosophila #Metabolism

https://www.biorxiv.org/content/10.1101/2023.03.02.530894v1

"In November 2021, Compass published its initial results from the study on people with treatment-resistant depression. A single dose of psilocybin, combined with therapy, was shown to have a significant effect in the short term, improving depression scores for 37 per cent of patients three weeks after the trial, with 29 per cent in remission."

https://www.ft.com/content/e8dbeaea-9b65-41ae-a86a-07e9c4058456

Bordalo II, Lisbon

The plot, as they say, thickens:

'Rishi Sunak is refusing to rush Britain back into the EU’s €95.5bn Horizon science programme despite his recent breakthrough in relations with Brussels, raising the prospect of a tough negotiation on rejoining the scheme.'

https://www.ft.com/content/409bccc7-8cb4-4f44-87c4-340d15147c55?sharetype=blocked