Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
Expansion microscopy is one of the best things to come along in #cellbiology. A new preprint from Ons M’Saad in the Bewersdorf lab at Yale describes methods for ~8000-fold volumetric expansion and labeling that deals with the dilution problem associated with such huge expansion. Cell-level details can be observed with a cell phone camera!
Thiago Carvalho
boosted
Introducing @emboreports to the fediverse!
We are a society-owned primary @EMBOPress #research #journal publishing papers, reviews and science & society commentaries from all areas of molecular #LifeScience #cellbiology #biochemistry #molecularbiology #immunology #microbiology #cancer #development #structure #signaling and many more.
Check us out: https://embor.embopress.org
Thiago Carvalho
boosted
Hecatomb: An End-to-End Research Platform for Viral Metagenomics | bioRxiv
"To me, one of the outstanding, clear failures in this pandemic—one that is fixable—is the way the vaccine rollout went. We were in an emergency and there was a limited supply and it meant rich countries were going to get vaccines first. To me, it is such an obvious problem to have a pandemic continue to surge for more than a year in a large part of the world, despite the availability of vaccines in a select number of countries."
Thiago Carvalho
boosted
Le #CNRS demande désormais à ses chercheurs et chercheuses d’appliquer la stratégie de non-cession des droits d’auteur (CC-BY 4.0) lors du dépôt de leurs articles auprès d’éditeurs.
Thiago Carvalho
boosted
RT @leslievosshall
Pls RT: the 2024 @HHMINEWS Investigator Competition officially opens for applications on Tuesday December 6. Check embedded 🧵 below for major enhancements that align with our values: open science, DEI, mentoring 1/4 https://twitter.com/leslievosshall/status/1585798911754530816
Thiago Carvalho
boosted
Intro post: We are a #Immunology lab at the Rockefeller University in NYC. We're interested in B cells and the #antibodies they make. We also develop LIPSTIC technologies to study how immune cells interact.
Shamelessly plagiarizing @ct_bergstrom, here's a perfect germinal center for your trouble.
Thiago Carvalho
boosted
An #introduction into our work on #glycotime! We are a lab joint between the Francis Crick Institute and the Department of Chemistry at Imperial College London. We develop what we call chemical "precision tools" to investigate protein #glycosylation. These tools are specific for individual #glycosyltransferases, #glycan subtypes or cell lines. We employ methods of #chembio including #OrgChem, protein engineering, #glycoproteomics, #imaging, #chemoenzymatic synthesis and drug discovery.
Thiago Carvalho
boosted
There is no such thing as the tragedy of the commons: a thread.
The oldest published reference to the idea is in a lecture by an early political economist at Oxford, William Foster Lloyd, in 1832 titled "On the Checks to Population." Lloyd first articulated the argument that many of us have been taught as an inevitable and immutable fact of economic life: that any resource owned in common will be exploited to the point of ruin.
"Why are the cattle on a common so puny and stunted? Why is the common itself so hare-worn, and cropped so differently from the adjoining inclosures? No inequality, in respect of natural or acquired fertility, will account for the phenomenon."
https://www.jstor.org/stable/1972412
1/
#capitalism #commons #tragedyofthecommons #anticapitalism #ostrom #anticapitalism #anarchism
Thiago Carvalho
boosted
#SmoothMuscleCell Piezo1 promotes high Phosphate-induced #Calcification & osteogenic differentiation of cultured👤aortic SMC (& culture🐭aorta)
How Piezo1-Ca2+ elevates expression of Runx2 & Transglutaminase 2?
Dr. Beatrix Dienes lab Front Physiol 2022
https://www.frontiersin.org/articles/10.3389/fphys.2022.1037230/full
First there were PAMPs (with a debatable 'P'). Then there were DAMPs. Somehow I'd missed plant HAMPs: herbivore-associated molecular pattern receptors
"Here, we analyze the consequences for CD8+ T cells of STAT3 GOF SH2 (K658N) or TA (T716M) domain mutations in the mouse germline and in people with germline STAT3 GOF syndrome. The findings demonstrate that diverse STAT3 GOF mutations cause oligoclonal accumulation of T-LGL-like effector CD8+ T cells and that the accumulation of these rogue T cells contributes to autoimmune pathology."
Thiago Carvalho
boosted
A little known feature of #Mastodon is the ability to create your own personal notes about an account.
This is a great way to potentially remind yourself why you follow particular accounts (or just about any other reason you can think of).
Also, these notes are private. The account does not know what you have written down, nor the fact that you have even made these notes.
Please #boost to help spread the knowledge around your networks. ☺️
#MastodonTips #Feditips #Notes
https://youtu.be/npoBM9Ev2CQ
Thiago Carvalho
boosted
“Zero-Covid is only a surface problem. Real problem is no constraint on state’s intrusion”
https://www.ft.com/content/71bf8a5d-3816-450b-bbfb-ec320b0dba0d
HATE to say this, but COVID is not a surface problem. This read of China's situation by both protestors & commentators risks disaster.
https://adamtooze.substack.com/p/chartbook-177-beijings-tragic-covid
From the Guardian's list of best science books 2022
'In This Mortal Coil (Bloomsbury), Andrew Doig, a biochemist at the University of Manchester, charts the fascinating history of how humans die. And if you think this might be a rather morbid topic, worry not. Despite some gruesome descriptions of disease and death, Doig tells an uplifting tale of how human ingenuity over the past few thousand years has allowed more of us to survive, and survive longer – first through innovations such as farming, and then by applying reason and evidence to health, defeating a host of major infectious diseases. For most of the history of our species, life expectancy was around 30. Today – thanks to the centuries of work by farmers, doctors, public health officials and others – people can expect to live to at least 70 or 80 in the world’s most developed nations.'
'Farmer, who has doe eyes and a nonchalant smile, often wore scrubs on her sales routes, despite not having a medical background. That way, she said, “I would automatically be seen as a help.” She tried not to mention death in her opening pitch, or even hospice if she could avoid it. Instead, she described an amazing government benefit that offered medications, nursing visits, nutritional supplements, and light housekeeping—all for free. “Why not try us just for a few days?” she’d ask families, glancing down at her watch as she’d been trained to do, to pressure them into a quick decision.'
https://www.newyorker.com/magazine/2022/12/05/how-hospice-became-a-for-profit-hustle
Thiago Carvalho
boosted
Expensive Taste.
Another amazing encounter with an otter, from a couple of years ago on Mull.
I had been watching two otters fishing in the loch for over an hour when one of them caught something large, and started swimming towards the shore.
I got into a location to watch from, and saw her splash through the waves and out on to the shore with a huge lobster in her jaws.
She spent half an hour eating almost all of it.
'El colegio Colonial de Pirque fue uno de los cuatro establecimientos educacionales latinoamericanos premiados en la COP27 por su rol activo en responder a los desafíos del cambio climático. Entre los cuatro ganadores de este premio llamado “Guardianes del Clima” y otorgado por Unicef, la Fundación Meri y la Oficina de Educación Climática de la Unesco, se encuentran también un colegio de Honduras, otro de Colombia y otro más de Argentina. A nivel regional se presentaron 175 proyectos al certamen.'
Thiago Carvalho
boosted
Two sister-papers on 🇲🇬 #biodiversity just published in Science:
1) Madagascar’s extraordinary Biodiversity: Evolution, distribution, and use (https://doi.org/10.1126/science.abf0869)
2) Madagascar’s extraordinary biodiversity: Threats and opportunities (https://doi.org/10.1126/science.adf1466)
Thiago Carvalho
boosted
An examination of over 1 million funding proposals to the National Science Foundation from 1996 to 2019 reveals that white principal investigators are consistently funded at higher rates than most non-white PIs and relative funding rates for white PIs have been increasing. https://elifesciences.org/articles/83071?utm_source=mastodon&utm_medium=social&utm_campaign=organic_features
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
