Thiago Carvalho @cyrilpedia@qoto.org

Biology Open helps researchers promote themselves alongside their papers through our #FirstPerson interview series... This week we showcased Rajeshwari B. R. the first author on ‘ Kinetics of Arf1 inactivation regulates Golgi organization and function in non-adherent fibroblasts’.

https://journals.biologists.com/bio/article/12/4/bio059944/308159/First-person-Rajeshwari-B-R

eLife

Metabolic activity organizes olfactory representations https://doi.org/10.7554/eLife.82502

New article! Read Microfluidic cell squeeze-based vaccine comes into clinical investigation https://www.nature.com/articles/s41541-023-00641-x?utm_source=dlvr.it&utm_medium=mastodon in npj Vaccines

Pictures Considered #59: Inside a Choanoflagellate

by Roberto
Choanoflagellates (endearingly referred to as "choanos") are the closest living relative of animals and as such they can provide insights into the evolution of animal multicellularity. Interestingly, at least two choano developmental features are induced by bacterial products.

Read more → https://schaechter.asmblog.org/schaechter/2023/05/by-roberto-fig-1-cut-away-view-through-the-center-of-a-70-cell-b-monosierra-choanoflagellate-rosette-3d-reconstruction.html

#microbiology #choanos

"#preprints really are communicating the most important parts of the #science as soon as they're ready" says Mark Hanson @MarkHanson, first author of the preprint awarded in the ‘Make your negative result a preprint winner’ competition.

Learn more about the competition, Mark's preprint and the value of the publishing negative results in the blog post https://asapbio.org/sharing-negative-results-via-a-preprint-a-conversation-with-mark-hanson

#OpenScience

@BiologyOpen
and our publisher
@Co_Biologists
offer a number of practical ways to help you meet the unique needs and challenges you may encounter as an #early-careerresearcher (ECR). Visit our dedicated ECR webpage to find out more: https://www.biologists.com/about-us/early-career/?utm_campaign=BiOSnippet
#Research #sciencemastodon #Scicomms

'A single dose of the human papillomavirus vaccine is highly effective at preventing infections over three years, most likely lowering rates of cervical cancer and other diseases linked to the virus, according to a new study in Kenya.'

https://www.nytimes.com/2023/05/02/health/hpv-vaccine-dose.html?action=click&module=Well&pgtype=Homepage&section=Health

"Personalized genome sequencing has revealed millions of genetic differences between individuals, but our understanding of their clinical relevance remains largely incomplete. To systematically decipher the effects of human genetic variants, we obtained whole genome sequencing data for 809 individuals from 233 primate species, and identified 4.3 million common protein-altering variants with orthologs in human."
#Preprint #Genomics #GeneticVariaton

https://www.biorxiv.org/content/10.1101/2023.05.01.538953v2

The Invisible Cities is a book everyone should read.

"No matter how fantastical those places are in Invisible Cities, he reveals that they’re all Venice. They’re all basically Marco Polo riffing about Venice. It’s his childhood home. Calvino touches on the idea of nostalgia, and I think in the ancient Greek sense of nostalgia—in trying to get home, you go off and you have these adventures"

https://lithub.com/darran-anderson-on-the-ever-shifting-magic-of-italo-calvinos-invisible-cities/

A reference framework to normalize human lymphocyte numbers in ageing.

'In this study, we analyze cross-sectional numbers of mainly T lymphocytes (CD3+, CD3+CD4+, and CD3+CD8+) and their subpopulations (naive and memory) from 673 healthy Dutch individuals ranging from infancy to adulthood (0–62 y). We fitted the data by a delayed exponential function and estimated parameters for each lymphocyte subset.'
#Immunology #Ageing

https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2200520/263658/Age-Dependent-Normalization-Functions-for-T?redirectedFrom=fulltext

'Our findings demonstrate that developmental bias in fly wings predicts evolvability and macroevolutionary trajectories on a much greater scale than previously appreciated but also suggest that causal explanations for such alignments may go beyond simple constraint hypotheses.'
#Evolution #EvoDevo

https://www.pnas.org/doi/10.1073/pnas.2211210120

This is definitely an area where it makes sense that AI could outperform humans.

'The new methodology is “remarkable”, says Dave Mauger, a computational RNA biologist who previously worked at Moderna in Cambridge, Massachusetts, a maker of mRNA vaccines. “The computational efficiency is really impressive and more sophisticated than anything that has come before.”

https://www.nature.com/articles/d41586-023-01487-y

Big thank you to #TheMicrobiologist for highlighting our recent work on a
biofilm-disrupting #bacteriophage. https://www.the-microbiologist.com/phage-delivers-double-whammy-against-biofilms/891.article

#Klebsiella #biofilm

Postdoctoral Research Scientist

https://jobrxiv.org/job/columbia-university-in-the-city-of-new-york-columbia-university-irving-medical-center-vagelos-college-of-physicians-and-surgeons-neurological-surgery-27778-postdoctoral-research-scientist/?feed_id=44364

#ScienceJobs #job
New York #UnitedStatesUS #Scientist
https://jobrxiv.org/job/columbia-university-in-the-city-of-new-york-columbia-university-irving-medical-center-vagelos-college-of-physicians-and-surgeons-neurological-surgery-27778-postdoctoral-research-scientist/?feed_id=44364

Jair Bolsonaro, who shared the 2020 Ig Nobel Medical Education Prize "for using the Covid-19 viral pandemic to teach the world that politicians can have a more immediate effect on life and death than scientists and doctors can", is in the news again. https://www.reuters.com/world/americas/brazil-police-raid-bolsonaros-home-part-covid-vaccine-probe-source-2023-05-03/

#scRNAseq of 18,900 pre-leukemic & leukemic cells reveals transformation of #Hematopoietic #StemCells into full-blown #AcuteMyeloidLeukemia, emphasizing the critical role of #RNAsplicing in the emergence & maintenance of #leukemia #PLOSBiology https://plos.io/3LOnfer

The Rap Guide To Consciousness

Yup, it exists. Baba Brinkman. "Let me show you how to be a good Bayesian ..."
https://www.youtube.com/watch?v=qV6Wc_f1Cgo