Johannes W. Dietrich @drjwdietrich@qoto.org
- Sektion DES / Klinik
- http://www.endokrinologie.org
apl. Prof. Dr. med. Johannes Dietrich, endocrinologist, head of the diabetes, endocrinology and metabolism section of #KKB @RUBMedizin. Views are my own.
Joined Nov 2022
Ich weiß ja nicht, wer mich vorgeschlagen hat, aber ich bin ab sofort im (ursprünglich 1925 begründeten) Kürschnerschen Deutschen Gelehrtenkalender aufgeführt. Nicht allzu wichtig, aber ganz nett 😅. Ob man aber für die 4 Bände über 1000 € ausgeben möchte...?
https://www.degruyterbrill.com/document/isbn/9783111635460/html
Die politischen Rahmenbedingungen der präventiven Medizin sind in Deutschland unzureichend. Zusammen mit anderen Europäischen Ländern ist Deutschland Schlusslicht in der #Prävention. Das führt dazu, dass die Kosten hoch sind, aber die Lebenserwartung niedrig.
https://blog.endokrinologie.net/politische-rahmenbedingungen-der-praeventiven-medizin-6001/
Mathematical modelling, computer #simulation, and machine learning upgrade #endocrinology. Applying principles of #biocybernetics and #biophysics, they enjoy growing interest and deliver novel methods for research, diagnosis, and therapy.
https://pubmed.ncbi.nlm.nih.gov/41852474/
https://doi.org/10.3389/fendo.2026.1806508
#MCT8 Deficiency, or Allan-Herndon-Dudley syndrome, is a rare severe disorder of #thyroid hormone transport. In our newest paper, we review the state of the art on pathophysiology, diagnosis & treatment.
https://pubmed.ncbi.nlm.nih.gov/41508830/
https://doi.org/10.1210/clinem/dgaf707
https://www.livivo.de/doc/M41508830
Systems modelling explains: A #cybernetic theory of the molecular processes in #COVID-19 predicts oscillatory #inflammation and virus load in severe forms, which result from increased #TMPRSS2 expression.
Severe #COVID-19 is a life-threatening condition, sometimes requiring #ECMO (extracorporeal membrane oxygenation) therapy. In one of our studies, we found that oscillatory inflammation heralds a poor prognosis.
https://pubmed.ncbi.nlm.nih.gov/36991018/
#Endocrine feedback loops belong to the important foundations of life. However, consistent underlying rules are still lacking. Now, Moriya Raz, Uri Alon, and co-authors describe 5 classes of control circles.
https://www.livivo.de/doc/M41271754
https://pubmed.ncbi.nlm.nih.gov/41271754/
https://doi.org/10.1038/s41467-025-65924-4
#Takotsubo syndrome is a dangerous stress-related #heart disease. Since #T3 upregulates β-receptors, we assumed a link to #thyroid homeostasis. With machine learning, we identified interesting allostatic patterns.
https://www.livivo.de/doc/M33179374
https://pubmed.ncbi.nlm.nih.gov/33179374/
https://doi.org/10.1111/joim.13189
Therapy with #TRIAC, a non-classical #thyroid hormone, relieves peripheral #thyrotoxicosis and hypermetabolism in patients with resistance to thyroid hormone β (RTHβ).
https://pubmed.ncbi.nlm.nih.gov/41131705/
There is an ongoing debate in #endocrinology about whether to treat #hypothyroidism with L-T4 alone or a combination therapy with L-T4 and L-T3. But what about patients’ preferences? The majority would choose the combination therapy, as shown in a meta-analysis.
Einladung zur 3. Endokrinologischen Abendsprechstunde: Up-to-date Schilddrüse 2025
Von der #Kinderendokrinologie über #Schilddrüse und #Nebenschilddrüse bis zur Arbeit einer Selbsthilfegruppe in der #Endokrinologie
Patients with #hypothyroidism, even when treated with levothyroxine (L-T4), face increased risk of #dementia and #fatality. Fortunately, the risk can be lowered again by a combination therapy with L-T4 and L-T3, as shown by a recent study.
Freue mich über meine geheime Wahl in die #Leibniz-Sozietät der Wissenschaften zu Berlin.
Mehr Infos:
https://news.rub.de/leute/2025-07-30-auszeichnung-johannes-dietrich-neu-die-leibniz-sozietaet-aufgenommen
#Syndrome_T, i.e. persistent symptoms and reduced #QoL despite normal #TSH concentration, affects 10% of #hypothyroid patients on #levothyroxine. Careful, multimodal and personalised treatment can result in significantly improved outcomes.
For the diagnosis and management of #hypothyroidism, measuring #TSH (thyrotropin) concentration is necessary, but it isn’t sufficient. Additional #biomarkers help to improve diagnostic power and to identify #endotypes of dysregulation.
The background of our observation is poorly understood, but others could confirm the findings, e. g. in this case report.
Complex regional pain syndrome (CRPS) goes along with secondary #hyperparathyroidism. Our group was the first to describe this. The mechanism leading to #sHPT is unclear, but it may contribute to the loss of bone substance in #CRPS.
The interaction of three hormones, #TSH, #T4 and #T3, lays the foundation for #thyroid #homeostasis and its #allostatic responses.
It is necessary to forgo a univariable sight and to consider the evolution of the multihormonal working point to understand health and disease.
Multiple feedforward motifs and feedback loops maintain #thyroid #homeostasis and #allostasis. The mechanism of relational stability maintains T3 in a balanced and safe range, even in conditions of declining thyroid function.
Signalling via #thyroid hormones is more than T3 and T4. It involves 27 molecules based on the thyronine skeleton, 10 transmembrane transporters, 3 deiodinases, 6 receptors, and 4 types of action, unfolding a complex firework of possibilities, explaining health and disease.
- Sektion DES / Klinik
- http://www.endokrinologie.org
apl. Prof. Dr. med. Johannes Dietrich, endocrinologist, head of the diabetes, endocrinology and metabolism section of #KKB @RUBMedizin. Views are my own.
Joined Nov 2022
