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Johannes W. Dietrich

Both sensorimotor and autonomic may be common in , despite treatment.

link.growkudos.com/1p62a9iults

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Johannes W. Dietrich

plays a key role in the pathogenesis of mellitus. In our newest paper, we show that treatment of () may cause remission of diabetes. CN: medical images in full text. pubmed.ncbi.nlm.nih.gov/391062 doi.org/10.1111/ddg.15490

The figure displays the patient’s glycated haemoglobin (HbA1c) over time. Hurley and IHS4 (International Hidradenitis Suppurativa Severity Score System) ratings before and after therapy are shown together with essential events (surgery and cessation of antidiabetic therapy). Therapy with adalimumab was continued during the entire period. Sitagliptin was discontinued at week 20.
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Johannes W. Dietrich

consumption may have prothrombotic effects via platelet activation and thereby increase the risk for major adverse cardiovascular events (). 🧪🩺

pubmed.ncbi.nlm.nih.gov/388420

Structured Graphical Abstract: Role of the artificial sweetener xylitol in cardiovascular event risk. In initial untargeted metabolomics studies (discovery cohort) and subsequent stable isotope dilution liquid chromatography tandem mass spectrometry (LC-MS/MS) studies (validation cohort), fasting levels of xylitol are associated with incident major adverse cardiovascular events (MACE). Using human whole blood, platelet-rich plasma, and washed platelets, xylitol enhances multiple indices of platelet reactivity in vitro. Xylitol also was shown to enhance thrombosis formation in a murine arterial injury model in vivo. In human intervention studies, when subjects ingested a typical dietary amount of xylitol in an artificially sweetened food, multiple functional measures of platelet responsiveness were significantly increased. Xylitol is both clinically associated with cardiovascular event risks and mechanistically linked to enhanced platelet responsiveness and thrombosis potential in vivo.
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Johannes W. Dietrich

Die Grafen von - waren ein bedeutendes Adelsgeschlecht der . Ihr Gebiet reichte von Oberbayern bis Südtirol und Niederösterreich. Ihre Stammburg wurde bei dem bayerischen schwer beschädigt.

sueddeutsche.de/bayern/unwette

Burg Unter-Falkenstein im oberbayerischen Inntal vor der bayerischen Hochwasserkatastrophe im Jahre 2024. Zu sehen sind der Bergfried, die Umfassungsmauern und mehrere Wehrtürme, im Hintergrund der Petersberg. Bildquelle: Rufus46, Wikimedia Foundation
Burg Unter-Falkenstein im oberbayerischen Inntal mit den Zerstörungen durch die bayerische Hochwasserkatastrophe im Jahre 2024. Zu sehen sind der Bergfried, die beschädigten Umfassungsmauern und ein Teil der noch erhaltenen Wehrtürme. Ein Turm wurde komplett zerstört. Bildquelle: Uwe Lein/dpa/Süddeutsche Zeitung
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Johannes W. Dietrich

Sensorimotor may be common in treated autoimmune thyroiditis, but, unlike in other causes of (e. g. ), it has a unique pattern in quantitative sensory testing () with low thresholds for mechanical and thermal pain.

doi.org/10.1038/s41598-024-631

Profile of quantitative sensory testing (QST) in autoimmune thyroiditis demonstrates low thresholds for heat and mechanical pain. Frequencies of abnormal QST findings (A) and mean sensory profiles (B) in patients with treated AIT. (A) Each column gives the percentage of patients with abnormal findings for a particular quantitative sensory testing (QST) parameter (outside the 95% confidence interval [CI] of healthy controls). Positive values indicate positive sensory signs (hyperalgesia); negative values indicate negative sensory signs (hypoesthesia, hypoalgesia). Dashed lines show expected value for healthy controls (± 2.5%). #p < 0.05 compared to the expected value of a healthy population. (B) Sensory profiles of all AIT patients presented as mean z scores + 95% CI. Positive z scores indicate positive sensory signs (hyperalgesia); negative z values indicate negative sensory signs (hypoaesthesia, hypoalgesia). Dashed lines show 95% CI for healthy controls (− 1.96 < z < 1.96).
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Johannes W. Dietrich

Should we, therefore, classify as a psychosomatic disease? This would be premature and probably wrong. We found signs of sensorimotor and autonomic that depend on autoimmunity and 's secretory capacity ().

Bar plot showing a significant association of markers of respiratory arrhythmia with anti-TPO antibody titres. Shown are means ± SEM (bars and whiskers) as well as results of individual participants (dots)
Significant correlation of functional parameters of thyroid homeostasis with the mechanical pain sensitivity (MPS) of QST (A), respiratory arrhythmia in HRV analysis (B) and depression percentiles in HADS (C)
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Johannes W. Dietrich

Our newest paper provides new insights into the conundrum of / . and are significantly more common in autoimmune compared to healthy controls.

doi.org/10.1038/s41598-024-631

Bar and dot plots show that both anxiety and depression are more common in autoimmune thyroiditis compared to healthy controls.
Anxiety and depression in three zones of autoimmunity. p** < 0.01, **** < 1e−4, ***** < 1e−5 compared to group with low antibody titres (anti-TPO Ab < 60 U/mL).
Anxiety and depression in autoimmune thyroiditis depend on autoimmunity. Shown are HADS percentiles in three zones of antibody titres.
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Johannes W. Dietrich

Stellenausschreibung für Medizinische Fachangestellte in der Sektion , und am KKB / UK RUB @RUBMedizin.

Wir freuen und auf Ihre Bewerbung!

klinikum-bochum.recruiting-por

Stellenausschreibung Medizinische Fachangestellte (m/w/d) Diabetologie und Endokrinologie zum frühestmöglichen Eintrittstermin in Voll- oder Teilzeit Unser Diabetes-Zentrum Bochum / Hattingen mit den Standorten St. Josef-Hospital (Bochum) und Klinik Blankenstein (Hattingen) bietet eine maßgeschneiderte Behandlung sämtlicher Diabetesformen - sowohl ambulant als auch stationär. Dafür greifen wir auf ein eingespieltes, interdisziplinäres Team aus Ärzten aller wichtigen Fachrichtungen, Diabetesberaterinnen, Podologen und Orthopädie-Technikern zurück. Wir sind von der Deutschen Diabetes Gesellschaft (DDG) für die Behandlung von Menschen mit Typ 1 und Typ 2 Diabetes mellitus zertifiziert. Angegliedert sind die Zentren für seltene endokrine Erkrankungen und Schilddrüsenmedizin. Das Katholische Klinikum Bochum ist ein Krankenhausverbund der Maximalversorgung und Träger von zehn Einrichtungen, angegliedert an das Universitätsklinikum der Ruhr-Universität Bochum (UK RUB).
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Johannes W. Dietrich

Telefonsprechstunde zu Schilddrüsenerkrankungen

Zum Weltschilddrüsentag am 25. Mai bietet das Schilddrüsenzentrum Bochum eine spezielle Telefonsprechstunde an, die allen Interessierten und Betroffenen offensteht:

Samstag, 25. Mai, von 11:00 bis 14:00 Uhr unter der Rufnummer (0234) 509-6095

Telefonsprechstunde zu Schilddrüsenerkrankungen: Zum Weltschilddrüsentag am 25. Mai beantworten Experten Fragen rund um Erkrankungen dieses kleinen, aber lebenswichtigen Organs Der Weltschilddrüsentag am Samstag, 25. Mai, ist für die Experten aus dem Schilddrüsenzentrum Bochum am St. Josef-Hospital ein wichtiger Anlass, um auf die Bedeutung der Schilddrüse und die vielfältigen Erkrankungen dieses kleinen, aber lebenswichtigen Organs aufmerksam zu machen. Sie bieten eine spezielle Telefonsprechstunde an, die allen Interessierten und Betroffenen offensteht: Samstag, 25. Mai, von 11:00 bis 14:00 Uhr unter der Rufnummer 0234/509-6095 Schilddrüsenerkrankungen sind häufig und betreffen Millionen von Menschen. Viele leiden unter Symptomen wie Müdigkeit, Gewichtsveränderungen, Haarausfall oder Stimmungsschwankungen, ohne die Ursache zu kennen. In der Telefonsprechstunde beantworten Experten aus der Chirurgie und der Endokrinologie Fragen rund um Diagnose, Therapie und Vorsorge.
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Johannes W. Dietrich

Die Deutsche Gesellschaft für , Informations- und hat Peter K. Fleissner und mir den Heinz von Foerster-Preis verliehen.

Ich danke meinen Lehrer:innen und Kooperationspartner:innen, die meine Arbeit im Laufe der letzten 30 Jahre möglich gemacht haben.

Urkunde über den Heinz von Foerster-Preis der Deutschen Gesellschaft für Kybernetik, Informations- und Systemtheorie e. V. an Johannes W. Dietrich
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Johannes W. Dietrich

Einladung zur Jahrestagung der Deutschen Gesellschaft für im Rahmen der Jahrestagung der Leibniz-Sozietät in Berlin. Es erfolgt eine parallele Life-Übertragung online:

leibnizsozietaet.de/event/2797

"Cybernetics is a way of thinking, not a collection of facts" [Erklärung der American Society for Cybernetics] Einladung zur Tagung der Deutschen Gesellschaft für Kybernetik am 11. April 2024 in Berlin (und parallel online).
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Johannes W. Dietrich

Sadly, John Midgley, a pioneer in diagnostics and co-author of multiple papers by our group, passed away. Read Rudolf Hoermann's obituary at The Guardian:

theguardian.com/society/2024/a

John Edward Maurice Midgley (1935–2023)
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Johannes W. Dietrich boosted
SPINA Team

#SPINA_GT, #SPINA_GD and Jostel's TSH index (#JTI or #TSHI) are predictors of survival in patients with #Takotsubo syndrome (#stress #cardiomyopathy), as recently demonstrated in the international GEIST registry.

pubmed.ncbi.nlm.nih.gov/385029
doi.org/10.1016/j.ebiom.2024.1

Table: Markers of thyroid function in the study population: FT3 and SPINA-GD are significantly decreased in non-survivors, whereas SPINA-GT is increased in fatal cases of Takotsubo syndrome.
Kaplan–Meier survival curves based on cutoff values derived from phi statistics. Low TSH, FT3, SPINA-GD and JTI as well as high FT4 and SPINA-GT predict shorter survival in Takotsubo syndrome.
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Johannes W. Dietrich

Our newest paper has been published. Based on machine learning with k-medoids we identified three different signatures of that predict the prognosis of patients with syndrome.

pubmed.ncbi.nlm.nih.gov/385029
doi.org/10.1016/j.ebiom.2024.1

Definition of clusters. Thyroid response and pituitary response curves denote the median of the thyroid’s secretory capacity (SPINA-GT) and empirical thyrotropic pituitary response. Cluster 1 (TSLT): Takotsubo syndrome with low thyroid output; Cluster 2 (TSHT): Takotsubo syndrome with normal thyroid output; Cluster 3 (TSNT): Takotsubo syndrome with normal thyroid output.
Association of clusters with total fatality (left, Mosaic plot) and time-course of survival (right, survival analysis with Kaplan-Meier plot). The survival is significantly worse in TSHT and TSNT clusters.
Table: Characteristics of the three clusters. The figures in the first two lines refer to medoids of TSH and FT4 concentration as identified by the clustering algorithm.
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Johannes W. Dietrich

Therefore, the non-increased and, in many cases, even reduced beta cell function in metabolic syndrome may not mirror an "either-or" question but be part of continuous evolution. It may be a source of prediabetes and diabetes but also prevent insulinoma.

pubmed.ncbi.nlm.nih.gov/381691

(A) SPINA-DI remains constant as long as changes in insulin sensitivity (as measured by SPINA-GR) are balanced by adequate variations in beta cell function (SPINA-GBeta, circles 1, 2, and 3). (B) If dynamic compensation fails, either due to insufficient adaptation to insulin resistance (circle 4) or primary beta cell failure (circle 5), the disposition index breaks down and is markedly reduced. (C) Computer simulations with systematic variations of insulin receptor gain (GR) and secretory capacity of beta cells (GBeta) and resulting blood glucose concentration. (D) SPINA-GBeta plotted against SPINA-GR in the definition dataset. Results of persons with normal glucose homeostasis are near the hyperbola of normal SPINA-DI (green dots). The ability of dynamical beta cell compensation is partly lost in persons with prediabetes (orange dots) or diabetes (red dots), resulting in lower SPINA-DI.
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Johannes W. Dietrich

The answer to this question may be in glucose toxicity leading to a biphasic response, thereby preventing neoplastic effects of dynamical compensation by mutant takeover.

pubmed.ncbi.nlm.nih.gov/286522

The blood glucose concentration stimulates insulin secretion and in a more complex way also the proliferation of pancreatic beta cells. They reproduce especially in situations of medium glucose concentrations and decrease in both low and high glucose levels (A). Thanks to the biphasic response, hypersecretory mutants die out (B–D).
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Johannes W. Dietrich

What is the primary event in the pathogenesis of type 2
– dysfunction of pancreatic beta cells or hypersecretion of ? This question is still unsolved and may represent a chicken-and-egg problem.

pubmed.ncbi.nlm.nih.gov/328943

Models of primary beta cell dysfunction and primary insulin hypersecretion in the pathogenesis of type 2 diabetes. (a) In the first model, the interaction of environmental factors with obesity and insulin resistance genes leads to the development of abdominal obesity and insulin resistance. This results in increased secretory demand on beta cells, which adapt by producing compensatory hyperinsulinaemia to maintain normal glucose tolerance. In contrast, in the presence of an early beta cell defect caused by genetics and environmental factors, the increased beta cell secretory demand leads to relative hypoinsulinaemia and the development of dysglycaemia and, ultimately, type 2 diabetes. (b) In the second model, beta cell overstimulation, which may be genetic or linked to environmental factors, leads to hyperinsulinaemia and this, in turn, produces obesity and insulin resistance. Type 2 diabetes ultimately develops when beta cell exhaustion occurs.
Crosstalk between the beta cell and insulin-sensitive tissues. (a) Model in which the degree of insulin sensitivity in the peripheral tissues (liver, adipose tissue and muscle) is the principal determinant of the magnitude of the beta cell response. With the development of obesity and insulin resistance (primary insulin resistance), the beta cells in the pancreas compensate by increasing the insulin response (secondary increased insulin response), thereby avoiding the development of hyperglycaemia. (b) Model in which the amount of insulin secreted determines the degree of insulin sensitivity in the peripheral tissues. In response to primary insulin hypersecretion by the beta cells, insulin-sensitive tissues decrease their sensitivity to insulin (secondary insulin resistance), thereby preventing the development of chronic hypoglycaemia.
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Johannes W. Dietrich

Simulation des Modells des --​es nach Bolie auf einem (THE ANALOG THING)

Simulating Bolie's model of insulin-glucose homeostasis with an analog computer (THE ANALOG THING)

Simulation des Modells des Insulin-Glukose-Regelkreises nach Bolie auf einem Analogrechner (THE ANALOG THING)
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Johannes W. Dietrich boosted
Scientific Pascal

Howard Page Clark, author of many books on programming with #Pascal, #ObjectPascal and the #Lazarus_IDE passed away. R. I. P. blaisepascalmagazine.eu

Obituary for Howard Page Clark
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Johannes W. Dietrich boosted
Scientific Pascal

The Apple Macintosh has turned 40. Originally, it was a #Pascal machine, and #ObjectPascal has been developed to evolve its revolutionary operating system.

Original add for the Apple Macintosh from 1984. "Introducing Macintosh. For the rest of us."
Mac SE with source code in THINK Pascal.
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