Delighted to get funding for #4DplusMetaFlux - moving towards measuring multiple metabolic fluxes in single cells in vivo……cue imposter’s syndrome 😬😬😨.
Thank god for my awesome collaborators @LindaVSinclair @svankasteren
---
RT @ERC_Research
We've just announced 90 new Proof of Concept Grants, ending the final round of 2022 competition. This brings to 366 the total number of grantees who received #ERCPoC under the ERC last year’s wo…
https://twitter.com/ERC_Research/status/1617841691528134657
RT @tcdflow
We're hiring an RA to work with me and Prof. Jean Fletcher (#flowcytometry and translational #immunology) in @tcdTBSI through the COVID-19 Immunology Research Hub. Please spread the word! Deadline Friday week... #hiring #immunologyjobs
Lymphatic vessels in the bone marrow!! 🤔
Sure why not. Makes sense now that I think about it 😁
#https://www.cell.com/cell/fulltext/S0092-8674(22)01574-4#.Y8lvSm_Vxy4.twitter
RT @SNI_NKMeeting
Registration is now open for #NK2023! Welcome to the north on September 26-29, we look forward to hosting you in Oslo, Norway and learn and discuss everything new about NK cells! http://nk2023.org/registration
SIZE MATTERS, when it comes to particulate adjuvants.
Very relevant for vaccine design. Great work by @RossWWard44 from @EdLavellee lab @tcdbi @tcdTBSI
---
RT @RossWWard44
Please check out our new paper just published in @CellRepMed - We show that for polymeric particulate adjuvants size matters!
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00478-5
We demonstate the size dependant adjuvanticity of polymeric parti…
https://twitter.com/RossWWard44/status/1616353700649512960
RT @metab_innate
🚨Last weeks #immunometabolism findings🚨@Bims_BiomedNews ⬇️⬇️⬇️
http://biomed.news/bims-imicid/2023-01-15
My highlights:
I) @DoctorKvoss & @JeffRathmell find T cell impairment in SLE arises from elevated Transferrin receptor & iron uptake @SciImmunology
II) GOT1 & CD8+ T cells @CellReports
RT @dr_p_g
Heads up! Macrophages influence DC (and their own) metabolism through nitric oxide. A cautionary tale for GM-CSF-derived DC cultures!
Check out the paper by Lucía @luminarrieta and Janet from the Berod lab @luberod
More insight into how pressure from our immune system shapes the tumours that develop, from Ping-Chi Ho’s lab. @PCHo_Lab
Immunoediting empowers tumours to disarm T cell by imposing metabolic tug-of-war between tumor and infiltrating T cells thus forming the suppressive tumor microenvironment.
https://www.cell.com/cell-metabolism/pdf/S1550-4131(22)00540-X.pdf
RT @metab_innate
🚨Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️
http://biomed.news/bims-imicid/2023-01-08
My highlights:
I) Microbial metabolite harmaline protects systemic inflammation via bile acid-GPR5 signalling
II) Sphingosine synthesis and S1P promote mito fission and trained immunity
Great review article on fatty acid metabolism and glioblastoma by @JasonMiska1. A really enjoyable read 👍.
https://www.jci.org/articles/view/163448#.Y7kQ6CH4YIE.twitter.
RT @ImmPRes_
flurry of updates coming your way. First up: Bach2 deletion can create super killer cytotoxic T lymphocytes. How do you ask? well it causes a massive increase in granzymes and perforin. This data from the @griffiths_lab is now up on ImmPRes #tcells #superkillers
RT @OnkTherapeutics
We’ve been named as one of BioSpaces’s NextGen 'Class of 2023', designating us as one of the most promising new life sciences companies in N.America this year. We’re driven by our purpose of pioneering optimally engineered #NKcell therapies to cure cancer.
https://www.onktherapeutics.com/onk-therapeutics-named-most-promising-company-in-biospaces-nextgen-2023-list/
The collection of immune cell proteomes is really growing at http://ImmPRes.co.uk. Simply fantastic resource.
#Tcells (of many types)
#NKcells
#Neutrophils
#Macrophage
#Bcells
#Basophils
#TheListGoesOn
I know for a fact there’s lots of new datasets on the way too 😁
---
RT @ImmPRes_
we have now added our first #neutrophil dataset to ImmPRes. What effect does hypoxia have on neutrophils when they're activated with LPS? and what happens …
https://twitter.com/ImmPRes_/status/1610671220810203137
🤣 love it.
---
RT @ATinyGreenCell
Salad spinners are the best plate centrifuges.
https://twitter.com/ATinyGreenCell/status/1610338801611587591
RT @DrCJ_Houldcroft
My favourite study of "how often does a family with small children get a respiratory infection?" is this one, from the USA:
https://doi.org/10.1093/cid/civ486
Children <5y have one of 16 common respiratory viruses detected in a nasal swab 50% of the year!
RT @Irishimmunology
We are very excited to announce that Prof @EdLavellee is to be awarded our Annual Award for Immunology 2022 for his contributions to Irish immunology research and education!
For more information about the award you can check out our website at https://www.irishimmunology.ie/annual-award
RT @lydfinley
Do you ❤️ the TCA cycle? (trick question). Our new review discusses the origins, discovery, and many functions of the mammalian TCA cycle. By @paigearnold2 @SKI_CellBiology out now in @jbiolchem https://www.jbc.org/article/S0021-9258(22)01281-9/fulltext
RT @WimGMeijer
Very sharp increase in SARS-CoV-2 levels in Dublin wastewater. As in the previous two years, viral levels peak during the Christmas period.
Data from 24 June 2020 - 14 December 2022
@UCD_SBBS @UCD_Research @IrishWater
@HSELive @nvrlucdireland @hpscireland #wastewater
RT @stephan_till
Our paper introducing PK Mito Orange (PKMO) has finally been published. It was a great pleasure to work together with @TianyanL on this project. Wonderful collaboration between @ZhixingChen2 and @JakobsLab!
We are an Immunometabolism research group that studies how nutrients and metabolism affect immune cell function at #TrinityCollegeDublin👨🔬 Love #NK_cells, #Dendritic_cells and #T_cells but can be easily convinced to talk at length about metabolism in any immune cell 😄. Twitter handle @DavidFinlayTCD