Effector CD8 T cells - fragmented mitochondria but glycolytic
Memory CD8 T cells - elongated mitochondria but use FAO and OXPHOS
Opposite way around to mechanism described by NGO et al.
🤔 Food for thought..
Other Immunometabolism examples? Reply..
(From Erika Pearce’s lab)
Oooooo, what’s that…mitochondria morphology controls Fatty acid oxidation (FAO). 🤔
Fragmented - CPT1 more active - ⬆️ FAO.
Elongated - CPT1 more sensitive to inhibition - ⬇️ FAO
Does this fit with what we know about Immunometabolism? 🤔🤨🧐
RT @OxfordDiplomat
An absolutely stunning video from Ireland’s Department of Foreign Affairs and Trade, celebrating not just St Patrick's Day, but a Century of Peace building, 100 years after our independence. Happy #StPatricksDay
one and all ☘️ #GlobalIreland 🇮🇪
RT @LallyLangford
This is dynamite from Kaveh Solhekol on Sky Sports News. Absolutely nails it. He has the Tories and BBC on toast. Well done!! 👏 Take 2 mins and watch👇#garylineker #ImWithGary #MOTD #ToryFascists
RT @JustMissEmma
Dear @GaryLineker
You were one of the first people to donate towards my fundraising for neurorehab, so In light of the shit show that’s unfolding right now, I thought I’d pick this moment to share that because of you and so many other incredible people here, I took my first… https://twitter.com/i/web/status/1634262665445908488
RT @Rainmaker1973
The theory of quaternions was born when a sudden thought came to William Rowan Hamilton as he was walking with his wife along the Royal Canal in Dublin, Ireland. It was the fundamental formula:
i² = j² = k² = ikj = -1
[read more: https://buff.ly/3pndnxN]
RT @AdamMGrant
We shouldn't listen to people because we agree with what they think. We should listen when we're impressed by how they think.
Intellectual loyalty is defending strong convictions. Intellectual integrity is being convinced by strong arguments.
A key to https://waitbutwhy.com… https://twitter.com/i/web/status/1628164690105847808
RT @VikiLovesFACS
We now have data on the safety of #CovidVaccines in #pregnancy from *nine* countries (thanks Romania!) 🇷🇴
👩🏻🔬 36 studies
🤰🏿 Including more than 364,068 ppl vaccinated in pregnancy
...find no increased risk of pregnancy problems.
1/
https://docs.google.com/document/d/19FNXcmdI0MU6RPmvKYo_g9zEWPKl2-l760OX_8zww3E/edit?usp=sharing
RT @tcddublin
Trinity has taken key steps to improve #funding for #PhD researchers, including consolidating the University’s three internal #postgraduate #research schemes and increasing their associated #stipends to €25,000.
Read more here: https://www.tcd.ie/news_events/top-stories/featured/trinity-takes-key-steps-to-improve-funding-for-phd-researchers-/
Delighted to see this. So much respect for you and all you do to communicate the data based evidence regarding the Covid vaccines and pregnancy. 💪👩🔬 #VaccinesWork #BelieveInScience
---
RT @ClareCollege
Viki Male (2004) returned to college to receive the alumna of the year award - set up to recognise individual contributions to society.
During the pandemic, Viki ensured pregnant people could access evidence-based information on the C…
https://twitter.com/ClareCollege/status/1625547468598394883
RT @UoDLifeSciences
Professor Doreen Cantrell has been named the British recipient of the Feldberg Prize 2023 from the Feldberg Foundation. This annual award to given to a scientist who is deemed outstanding in their particular field.
https://buff.ly/3Yg2MTO
@UoDCellSigImm
RT @VikiLovesFACS
🏴 1,574 babies exposed to #COVID infection before 20 weeks of #pregnancy, compared to 4,722 uninfected controls
👉🏻 No increased risk of congenital anomalies associated with infection
2/2
RT @VikiLovesFACS
🏴 6,731 exposed to #CovidVaccination before 20 weeks of #pregnancy, vs 20,193 controls
👉🏻 No increased risk of congenital anomalies
👉🏻 Including when analysis was restricted to vaccination in the vulnerable window before 10 weeks of pregnancy
1/
RT @tcddublin
Professor Cliona O'Farrelly has today been named a 2022 @aaas Fellow. Cliona has been honoured for her outstanding achievements as a researcher in the field of comparative immunology.
Read more at: https://bit.ly/3jjlGdb
RT @LindaDoyle
It's been a great week on the @ERC_Research front with two Trinity researchers winning Proof of Concept Grants and another two winning Consolidator Grants!
Congratulations everyone 🎉
RT @TrinityMed1
Exciting news for the school this morning with the announcement of @SDoyleTcd's award from the @ERC_Research for her ground-breaking investigations for novel immunotherapies to fight blindness. Congratulations Sarah! Read more about Sarah's research here: https://bit.ly/3JBdQGm
RT @MolecularTcd
📢#jobalert Looking for a Postdoctoral Fellow to join the team!
Translational project to identify early molecular signatures which might predict onset of #RheumatoidArthritis
Deadline: 31st Jan 2023.
🔗https://rheumatologytcd.com/
🔗https://arthritissvuh.com/home/
RT appreciated
RT @ImmPRes_
did you notice that in the last release we added a feature to study protein families. For example, how about looking at the glycolytic proteins and how they change upon T cell activation in CD8s? #glycolysis #tcells #proteomics
Easily done in the heatmap section 😎
We are an Immunometabolism research group that studies how nutrients and metabolism affect immune cell function at #TrinityCollegeDublin👨🔬 Love #NK_cells, #Dendritic_cells and #T_cells but can be easily convinced to talk at length about metabolism in any immune cell 😄. Twitter handle @DavidFinlayTCD