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Hello, all. I’ve been around for a few days but haven’t yet made an post. So here we go.

I’m a consultant with The Bioinformatics CRO working on a variety of small and large projects ranging from fundamental genomics to clinical decision support. Before that, for several years I was a postdoc and ORISE fellow specializing in high-altitude medicine and physiology at the University of Colorado Altitude Research Center. My academic background is a nearly even mix of , machine learning, and biology.

The ARC* has been sadly moribund for a few years, but thanks to collaborations with other groups, we’re starting to get more active again. Hopefully I will have more to say about that in the future. Meanwhile, feel free to ask me anything about medicine—I think I still remember most of it.

Years before that, I was an Air Force (after a brief stint as an Army infantryman) followed by a couple of years as a civilian EMT. My time in patient care informs my approach to science: the numbers I crunch represent human lives.

Otherwise, I’m an armchair hoping to be able to call myself an amateur paleontologist again one of these days—by which I mean actually spending some time in the field and/or the prep lab—a too-occasional science fiction writer, and chronically sleep deprived. Also, my life is the internet: it’s cats all the way down.

*Fellow fans may recognize the jacket in the picture. My wonderful fiancée found it for me when I was hired at the ARC, for exactly the reason you think.

Some setting the record straight about Thomas Matthew , the attempted of convicted felon and adjudicated sex offender Donald John . This is as much for my own reference as anything, but I’ll be happy if it’s useful to anyone else.

The following are verifiable facts:

  1. He donated money to the Progressive Turnout Project, a . Early reports that the donor was another Thomas Crooks, living in another part of Pennsylvania, appear to be false.

  2. He was a registered . He donated to PTP on January 20th, 2021, the day Biden was inaugurated, when he was 17. He registered as a Republican in September 2021, shortly after he turned 18.

There is really no contradiction here.

It’s hard to remember now, but Joe took office with very high approval ratings. My guess is that like a lot of other people, Crooks was feeling pretty good about President Biden in January 2021, but soured on him by fall of that year. There was no good reason for this; people didn’t give President Biden nearly enough time to clean up the mess convicted felon and adjudicated sex offender Donald John Trump left behind. But the rapid change in the national mood is undeniable.

Many people are pretty aimless in their late teens and early twenties, searching for an adult identity. Crooks was an extreme and tragic example.

There is a very long conversation to be had about why members of a certain demographic to which he belonged are much more prone than others to turning their search for identity into grotesque violence—but that’s not what this post is about. Just trying to make sure the facts are clear. Supporters of convicted felon and adjudicated sex offender Donald John Trump don’t care about facts at all, as they’ve shown over and over. We can and should do better.

So now that the facts are clear, let’s get back to making sure convicted felon and adjudicated sex offender Donald John Trump never gets within a mile of the White House again, by legitimate means if at all possible.

evolved. It rebelled. There are many noodles. AND IT HAS A PLAN.

My Facebook Memories from 2020 and 2021 are full of posts about -19. It’s so weird to me how that’s just vanished from the national conversation.

Everyone knew at least one person who died from it, often more than one. Nearly everyone was terrified of dying from it themselves, and the ones who weren’t were burying their heads in the sand. It killed a million Americans in a year and a half—more than every war we’ve fought, combined, for a century and a half. At its height, it was far and away the leading cause of death. It still kills people, albeit at a much reduced rate: far less than the big killers like heart disease and cancer, but about ten times as many as die in motor vehicle accidents. You know, by way of comparison.

And it will happen again. Maybe a new strain of SARS-CoV2, maybe influenza, maybe something else entirely. Something is out there right now, something that doesn’t infect humans, or causes at most mild symptoms, or isn’t easy to catch. Yet. Mindlessly waiting for the next mutation, for its turn.

I don’t know what it’s like in other countries. In the US, we seem to have collectively decided to pretend it never happened. We’re good at that, of course—if we weren’t, the current political landscape would look very different. And I don’t want this to be about politics, but of course it is. When the next plague strikes, and the next after that, and the next after that, our response will depend critically on who’s in charge. Sorry, folks, pathogens don’t care about market-based solutions.

Honest, I’m not trying to ruin anyone’s day. I just can’t quite believe that we’ve all tacitly agreed to this case of national amnesia. But I suppose I don’t have much choice.

I’ve written posts like this before, and no doubt will again. But I think it’s a drum worth beating.

Here’s the thing about ad hominem and its obverse, argument from authority: they’re not always wrong. Overall, I’d guess (without making any claims of having actual evidence) that they’re right more often than not.

In a perfect world, we’d have full information about everything, all the time, and could evaluate any claim purely on its merits. But of course we don’t live in that world. So we have to trust people who know more about a particular subject than we do, and who have a record of talking about the subject honestly … and we’re wise to distrust people who are demonstrably ignorant, or who have a record of lying.

I know a whole lot about gene regulation, a fair amount about gene-disease prediction and gene-drug interaction, and a little about everything else that falls under the bioinformatics umbrella. Thanks to my former career, I remember a great deal about emergency medicine and infectious disease epidemiology, but while that’s still useful knowledge, it’s out of date. And I know a little bit about paleontology, purely as a hobby.

That’s about it. On those subjects, particularly those at the top of the list, I’m trustworthy. People who haven’t studied them at all should believe what I say.

On everything else … I’m at best a well-informed layman, and often not even that. Like everyone else: nobody can possibly know more than a tiny sliver of everything there is to know. There aren’t enough hours in a day, days in a year, or years in a lifetime to do any more.

You also have people—a lot of people—who are proudly, willfully ignorant, but talk endlessly on the subjects they know the least about. Most creationists, antivaxers, and climate change deniers fall into this category. They take their cues from the much smaller number of people who are knowledgeable in the subjects at hand, but are deliberately lying for ideological reasons. These people know enough to craft convincing lies which the rest then repeat at length.

When you’re dealing with qualified experts in a field not your own, who have given no reason to think they’re habitual liars, the best source of knowledge is what they say. If the experts disagree, the best you can do is listen to what most of them say. The majority may be wrong, and the minority may be right—but that’s for them to hash out. Kibitzers are almost guaranteed not to make any meaningful contribution to the conversation.

And when you’re dealing with people who have shown they’re habitual liars, or who proudly proclaim their ignorance but nonetheless have a strong opinion, by far the wisest course is to dismiss their claims out of hand. Ignore them if you can, mock them if you like, fight them if you must. But never let them pretend their voices are equal to those of people who have a meaningful say. Both-sides-ism is a fatal trap.

James is dead. I hope his spot in Hell is at a pleasant temperature when he arrives, but then steadily gets warmer … and warmer … and warmer … Satan should be very amused by his constant denials.

I bet you can guess the context.

“Of course. Everyone is ignorant of nearly everything. The totality of human knowledge is too vast for any one person to learn more than a tiny fraction of it in a lifetime, and all possible knowledge is far greater than that. All I can do is try to learn my little sliver, and maybe if I’m lucky contribute a little more.

“But I do know how we know what we know, and some dude sitting in his truck making a YouTube video about how evolution is fake and vaccines are a (((globalist))) plot and global warming is a hoax because it snowed yesterday ain’t it.”

Exactly this.

I cannot stress this enough - SCOTUS did not define what is an official act. So all you folks saying "well okay so now Biden can..." are not gettin...

Leave aside the self-evident truth that the ’s ruling was purely for ’s benefit. Leave aside the near certainty that it will be applied generously to , and stingily if at all to anyone else. Leave aside the breathtaking level of judicial activism required to create a class of immunity with no grounding in precedent or the plain language of the .

Other than that, Mrs. Lincoln, how was the play?

This is a terrible idea. In a sane world, breaking the law cannot be an official act, because the ’s chief responsibility in office is to “take Care that the Laws be faithfully executed.” By saying that a category of official acts which are immune to prosecution exists, even hypothetically, the Court has placed any President, current or former, beyond a substantial portion of the law’s reach. Any President to whom the (in)Justices in their wisdom deem it to apply, anyhow—but again, that’s a side issue.

For anyone who disagrees, here’s a challenge: think of one official act, any possible action the President as President could take, which requires immunity but is still within the law. One. Take all the time you need.

It’s the macro-scale version of cops never writing each other speeding tickets. We should demand a higher standard from people we give power to execute the law, or at the very least an equal one. Instead we wink and nod at blatant abuses of that power. This does not strike me as a recipe for long-term national survival.

“Shocked but not surprised” is getting a real workout these days.

This is an excellent analysis of the fallout from the . TL;DR: ’s not going to step down, there’s no reason for him to step down, and the will go on pretty much as before.

But I urge you to read the whole thing. And if you find yourself tempted to comment in response to my one-sentence summary, without following the link … do it somewhere else.

And this kind of thing is why I keep coming back to , for all its sins.


Did 3rd wave cause the movement?

The MGTOW movement has been around for fucking centuries. It was just called bachelorhood and it was celebrated. The “nagging wife” image of her beating the man over the head with a rolling pin (gee, let’s check the stats on domestic abuse…oh. Wow.) The “old ball and chain.” Men giving away the bride to (usually) another guy. Feminism, regardless of wave number, or any type of societal breakage by women was met with the increasing levels of hatred and vitriol. You see, these guys who say “men built society” are correct. But the next time you hear that, you may want to ask “for whom did they build it, jackass?” Because it sure as shit isn’t built for fucking women.

This is why the very idea that society needs a “mens movement” be it MGTOW or red pill or MRAs is laughably fucking absurd. If you want to jerk yourself off for “building society” the least you could do is take responsibility for not building it on a nearly equitable level. Feminism looks to rectify that. Nothing caused the MGTOW “movement.” It just went online and went from being Henry Higgins singing 🎶LET A WOMAN IN YOUR LIFE🎶 to….just insufferable fucking whining. Spoiled little shits, the lot of ‘em.



The system is working as designed.

Chuck Darwin  
When Arizona passed the legislation that allowed for ♦️private (religious) school vouchers♦️ the program was projected to cost $65 million in 2024 ...

This seems like sound advice.

Jens Clasen  
Hello people of the US, Germany here. We have a bit of experience with a convicted felon and radical right-wing extremist becoming leader of our co...

It's really amazing to me how many people are not denying the crimes committed but that he should not have been charged for them since, checks notes, they aren't real crimes and they, again checks notes, "aren't able to convict him on anything real".

Huh. All righty then.

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