Nicola Romanò @nicolaromano@qoto.org

A new version of our "Current state of #singlecell #proteomics data analysis" pre-print is available on #arXiv.

We compare the computational workflows used over the last four years and identify a profound lack of consensus on how to analyse SCP data. There's a clear need for benchmarking, standardisation, and better experimental designs. We cover the current standardisation efforts, list remaining missing pieces, and conclude with lessons learned from replications.

(1/2)

Neuronal growth cones from neurons isolated from a giant sea slug (Aplysia californica) photographed through a microscope. #CellBiology #CellBio2022

Mondrian Crescent

I love it when train doors align at the end of a tunnel. The red tiles at Green Park station make this the ideal location to capture this moment.

It wasn't luck though, instead I froze the moving train with a fast shutter. It took ages to get it centred.

This final image resembles an abstract art painting by Piet Mondrian.

#art #mastoart #abstract #architecture #photography #potd #symmetry #london #underground #londonunderground #railway #mondrian #tiles #photo

BEHOLD

I have survived another year despite the machinations of my haters, which can mean only one thing:

It's time to BATTLE SOME JAMS

Welcome to the Third Annual

"24 Days Until December 25th"

Ranking of the Entrants in the Bonne Maman Non-denominational Calendar of Jams!

#jamvent

I was diagnosed with #HIV in 1998, when I was 30.
At the time, I did not expect to live to 50.
I’m 55 now.
HIV treatment works and it means I can’t pass it on - we call this #UequalsU.
HIV changed. Tell everyone.
#WorldAIDSDay #WorldAIDSDay2022 #AIDShistory #CantPassItOn #FightStigma

Yesterday in my BIO/INFO 270 class I lectured about predatory publishing. Whether or not you think Hindawi falls into that category, they need to be doing a much better job of vetting the articles they publish.

Via Josemari Feliciano over at twitter, one of the worst examples of a #DatavizFail #GraphCrime that I've ever seen from this paper:
https://www.hindawi.com/journals/amse/2022/3802603/

Look closely: These are not error bars. They are literally the typeset letter "T" placed atop each bar in the bar graph.

I hear new people noting how chill, tolerant, and pleasant Mastodon is.

Mastodon isn’t chill or tolerant or pleasant. It’s a tool… a foundation on which to create and maintain a culture.

It’s those who’ve been on Mastodon, run servers, and served as admins who did the hard work and created the culture you now enjoy.

Now, it’s your turn. The only way it stays tolerant and chill is by us doing the work to keep it that way.

A good example of, “Be the change you wish to see in the world.”

3,013 neurons, half a million synapses: the complete #connectome of the whole #Drosophila larval brain!

Winding, Pedigo et al. 2022. "The connectome of an insect brain" https://www.biorxiv.org/content/10.1101/2022.11.28.516756v1

We’ve mapped and analysed its circuit architecture, from sensory neurons to brain output neurons, as reconstructed from volume electron microscopy, and here is what we found. 1/

#neuroscience #connectomics #vEM #volumeEM

"Why don't we share data and code?" Nice and concise infographic about perceived barriers and benefits. Full article: https://royalsocietypublishing.org/doi/10.1098/rspb.2022.1113

So, the European Union has set up its own Mastodon instance, EU Voice, as an official channel/platform for all its many institutions - what a great initiative https://social.network.europa.eu/about
#TwitterMigration #europe #Diplomacy #Transparency

Growth.

I have been using Git a long, long time. I have worked on Git clients and libraries. At some places I've worked, I am the person folks go to when they need Git help.

And yet, only today I learned you can pass -m to commit twice (or more) and it will do the right thing of making each successive message a new paragraph (which is useful for the convention of a short summary as a single first line and following paragraphs as a more detailed message).

Has anyone ever investigated whether people (researchers or lay people) are more convinced from pregistered / many labs / many analyst projects compared to "normal" projects?

BREAKING: Democrat and indigenous Alaskan Mary Peltola officially wins race for Alaska’s only House seat, defeating Pro-Trump Republican Sarah Palin.

2/ Let's just forget for a second that #predictive #crime is just quackery anyway, extremely stupid mistakes are being made. For example, if your name is in the police systems because of something somebody else did, that was considered an indicator by the #algorithm (called #ProKid). Amateur hour.

@polka @PracheeAC

On the photocopier and peer review claim: yes, nice story, but...

Typewriters+carbon paper (or indeed, just 'typewriters + copy typist) could make multiple copies of papers way before photocopiers became common. But the journals I've looked at weren't asking for multiple copies (though they were requesting typescript rather than handwritten).
I suspect the rise in use of peer review in the third quarter of 20thC coincides with photocopiers but wasn't caused by them.

Dear students:

If you’re considering emailing a former professor just to check in and say hi, but are hesitant because you have nothing substantive to say, consider this an invitation to go ahead and send that email. It really means a lot.