Nicola Romanò @nicolaromano@qoto.org

Born in 1896, biochemist Gerty Theresa Cori became the 1st woman to be awarded the Nobel Prize in Physiology or Medicine (and the 3rd to win a Nobel Prize).

Cori faced gender discrimination & was marginalized for years. But she never gave up.

With her husband Carl, she discovered how glycogen is broken down & eventually stored as an energy source (aka the “Cori cycle”). They also identified the Cori ester. http://beckerexhibits.wustl.edu/women/cori.htm #HistoryRemix #science #history

'Hilariously, Sunak insists anyone failing to get behind all this just wants to take us “back to square one”. Square one? Oh man – who wouldn’t take square one in a heartbeat? We’re somewhere near square minus 39 here, receding backwards through the squares until the place of utter darkness beyond all squares'

https://www.theguardian.com/commentisfree/2024/jan/19/tories-squid-game-rwanda-policy

Hello, what is 'synthetic data'? Specifically, how can synthetic data be sufficient for creating models to run on real-world data? Would it not replicate the narrowness of the small real data they had to begin with?

Do I know anyone on here who explored what kind of niches synthetic data helps & where its use is being over-shot beyond the effective boundary?

Tagging to hope to reach to someone who worked on this #machinelearning

This paper starts out amazing and just keeps getting better

https://arxiv.org/abs/2401.06133

Hey, congratulations on that new #rstats package! Or, maybe well done on keeping that old package maintained! Either way, have you thought about letting your users try it out in the browser straight away? It's really easy with WebR and #QuartoPub!

https://jamesgoldie.dev/writing/your-new-r-package-webr/

Wow. Start a friendly VoIP call with a target, record the audio, find patterns in their GPU activity (exploiting the fact the GPU's electro-magnetic fields are captured by the target's built-in PC microphone and can be distilled from the acoustic audio sources), match the patterns against pre-trained classifier and deduce some of the target's web activity, cryptographic secrets, position within a video game. It is mind-boggling. #cyber #security #research #machinelearning
https://faculty.cc.gatech.edu/~genkin/papers/lendear.pdf

Gendered hiring and attrition on the path to parity for academic faculty. #EDI #DEI https://elifesciences.org/reviewed-preprints/93755?utm_source=mastodon&utm_medium=social&utm_campaign=organic

Camembert is an endangered species! It relies on a mold that had lost the ability to reproduce sexually... and now, thanks to inbreeding, this mold has also lost the ability to reproduce using spores. Roquefort is also in trouble, but for Camembert it's worse:

"The world over, this other symbol of French gastronomy is inoculated exclusively with one single strain of Penicillium camemberti, a white mutant that was selected for Brie cheeses in 1898 and Camemberts in 1902.

The problem is that ever since then the strain has been replicated by vegetative propagation only. Until the 1950s, Camemberts still had grey, green or in some cases orange-tinged moulds on their surface. But the industry was not fond of these colours, considering them unappealing, and staked everything on the albino strain of P. camemberti, which is completely white and moreover has a silky texture. This is how Camembert acquired its now-characteristic pure white rind.

Year after year, generation after generation, the albino strain of P. camemberti, which was already incapable of sexual reproduction, lost its ability to produce asexual spores. As a result it is now very difficult for the entire industry to obtain enough P. camemberti spores to inoculate their production of the famous Norman cheese.

Worse still, while the Roquefort PDO (Protected Designation of Origin) standard retains a degree of microbial biodiversity, the PDO specifications for Camembert require farmers and other producers to use P. camemberti exclusively."

What to do about it? Read on....

(1/2)

#statstab #8 Step away from stepwise

Thoughts: Pretty straightforward, don't use stepwise regression. It is atheoretical and can produce causal inference mistakes; it is also a misuse of p-values.

#rstats #pvalues #regression #nhst

https://journalofbigdata.springeropen.com/articles/10.1186/s40537-018-0143-6

The first 2 weeks of my (anti-)stats course, Statistical Rethinking, are over. We covered the foundations of Bayesian updating and model building. But you can jump right into week 3 - focuses more on structural confounding and causal inference. Hum over the stats details, let the warm light of generative modeling wash over you. Full lecture list (FREE): https://github.com/rmcelreath/stat_rethinking_2024#calendar--topical-outline

TIL if you track a package on ups.com, it will send your full tracking link including the tracking number to both Google and Facebook.

This is just "normal".

Use an ad-blocker, folks.

Course on "Quantitative Imaging: From Acquisition to Analysis"

Application deadline: January 31st

Course dates: April 1-16

Location: Cold Spring Harbor

Instructors: Jennifer Waters, @bethcimini @florianjug Hunter Elliott, Talley Lambert, Suliana Manley.

Financial aid is available to help offset tuition costs.

https://meetings.cshl.edu/courses.aspx?course=C-QICM&year=24

#microscopy #imaging #biology #bioimage

NumPy 2 is coming out in couple months! And it's a little backwards incompatible, which means any applications that depend on it (directly or indirectly) might break.

I wrote an article showing how to prevent breakage in the short term, and how to automatically upgrade in the long term.

https://pythonspeed.com/articles/numpy-2/

#Python #NumPy

2 days ago- in 1982 the Commodore 64 was introduced by Commodore Int'l at the Consumer Electronics Show in Las Vegas. The units were available in stores Aug '82. #80s #80stech

Gotta check these out!

Robust, scalable, and informative clustering for diverse biological networks

https://genomebiology.biomedcentral.com/articles/10.1186/s13059-023-03062-0

#bioinformatics #genomics #genetics #statistics

@floe
Maybe you have part of your answer already in this preprint from last year?

"We reran an abstract summarization task from the literature on Amazon Mechanical Turk and, through a combination of keystroke detection and synthetic text classification, estimate that 33-46% of crowd workers used LLMs when completing the task"

https://arxiv.org/abs/2306.07899

Tasks, and the reputation management of participants on different platforms, may be influential here

Hey, #rstats champions! Sometimes you might want to consider reordering 🔀 your boxplot groups to more clearly illustrate the differences between them. You can easily achieve this with the `reorder` function within your aesthetic mappings. Check out my blog for a full working example and code.

🔗 https://lpembleton.rbind.io/ramblings/R/#order-a-boxplot-for-improved-across-axis-comparisions

Do you want to identify the neighbours of your favourite cells but are unsure where to start?

Check out our Primer, just out in @Dev_journal , for an overview of synthetic neighbour-labelling systems and of how they can be used in developmental settings.

Huge thanks to @CellySally, Tamina Lebek and Guillaume Blin for a real fun writing experience!

#DevBio #SynBio #StemCells #Cell #Cells #Development #SyntheticBiology #Synthetic #Biology #Science #ScienceMastodon

https://doi.org/10.1242/dev.201955

@ionica This story has a rather *excellent* graph, which should get some sort of graph award 🙂

https://www.abc.net.au/news/2024-01-09/magpies-swoop-bald-more-often-survey-finds/103297520