Exploring root branching in silico
A Research Highlight showcasing new work from Joana Santos Teixeira, Thea van den Berg and Kirsten ten Tusscher
Read the full #OpenAccess Research Article, ‘Complementary roles for auxin and auxin signalling revealed by reverse engineering lateral root stable prebranch site formation’ here: https://journals.biologists.com/dev/article/149/22/dev200927/283180/Complementary-roles-for-auxin-and-auxin-signalling
This article is available under our #ReadandPublish Open Access initiative.
Induced #EndothelialCell KLF4 KO in adult🐭->
Lung Inflammation+Fibrosis within 1 month😎
KLF4-KO EC has⏫KLF2 & #EndMT simultaneously!
Perturbed shear-sensing?
Link b/w⏫KLF2 & #EndMT?
EC secretome? So interesteing😆
Dr. Kishore Wary lab @FrontCellDevBio 2022 @KishoreWary
https://www.frontiersin.org/articles/10.3389/fcell.2022.1003028/full
A potential FGF9-TCF7L2 (#Wnt)-HAS2/#HyaluronicAcid cascade in #Palatogenesis #CleftPalate
GeneMANIA, a useful resource to explore gene relationships
http://www.genemania.org
Dr. Zhenqi Chen lab @Biomol_MDPI 2022
https://www.mdpi.com/2218-273X/12/11/1639/htm
SlideCNA: Spatial copy number alteration detection from Slide-seq-like spatial transcriptomics data https://www.biorxiv.org/content/10.1101/2022.11.25.517982v1?med=mas
Itga8-CreERT2, a novel tamoxifen-inducible #SmoothMuscleCell-specific Cre🐭
Selective for Vascular over Visceral (GI/Airway...) SMC🤠
Critical comparison (+Aorta transcriptomes) vs Myh11-CreERT2
Dr. Qing Lyu & Joseph Miano labs Nature Cardiovascular Research 2022
https://www.nature.com/articles/s44161-022-00162-1
#Oncology #oncologyresearch An estimated 1 million cancer diagnoses have been missed across Europe in the last 2 years.
With experts warning of a 'cancer epidemic in the next decade', a new @TheLancetOncol Commission outlines steps to strengthen the research landscape:
📌https://www.thelancet.com/commissions/European-Groundshot-cancer-research?utm_campaign=lanoncgroundshot22&utm_content=229456552&utm_medium=social&utm_source=twitter&hss_channel=tw-27013292
📌 https://www.thelancet.com/commissions?filterModify=true&journalFilter=&categoryFilter=lancet-clinical
Normal & abnormal development of the aortic valve & ascending aortic wall: a comprehensive overview of the Embryology & Pathology of the #BicuspidAorticValve
Dedication to Dr. Adriana Gittenberger-De Groot
Dr. Nimrat Grewal & colleagues Ann Cardiothorac Surg 2022
https://www.annalscts.com/article/view/16943/html
Chromatin landscape dynamics of #SmoothMuscleCell in #Atherosclerosis🐭
Integrated scATACseq+scRNAseq+lineage tracing analysis reveals a protective role of ATF3 in atherogenic #Complement 3+ SMC
Dr. Ying Wang & Nicholas Leeper lab #CardiovascRes 2022
https://academic.oup.com/cardiovascres/article/118/13/2792/6438000
For #FluorescenceFriday, here is an #HHMIJanelia FlyLight #Drosophila Split-GAL4 volume (LH2041) in magenta, with a matching FLyEM Hemibrain V1.2.1 skeleton (LHPV12a1, 480590566) in green. The match was found by the color-depth search algorithm of Hideo Otsuna, Masayoshi Ito, and Takashi Kawase running in the NeuronBridge system (https://neuronbridge.janelia.org). Volume rendering in NeuronBridge is interactive, so in addition to this view...(1/5)
We have an opportunity for an outstanding scientist to establish their research group at the Perutz. The successful candidate will be offered an #assistantprofessor position at the Medical University of Vienna. Read more: https://tinyurl.com/4hjm863y #sciencjobs #facultyjobs #academicjobs
Across scales: our neuronal cultures (🔬 top) and the distribution of dark matter in the universe (🔭 bottom)
RT @CNRS@twitter.com
#CNRSleJournal 📰 Quels sont les liens entre l’infiniment petit et l’infiniment grand ? Comment les briques fondamentales de la matière s’assemblent-elles pour former des étoiles, des galaxies ou des trous noirs ? Tout juste paru, le livre "Étonnants ... https://bit.ly/3EXOIqP
Honored to be awarded the Alexander von Humboldt professorship with Physics of Life (@PoLDresden) at TU Dresden (@tudresden_de)!
This means that I will start building a new lab in PoL/TU Dresden, Germany next spring. My group will also have a space at Max Planck CBG (@mpicbg). 1/
Decoupling #TGFβ1 with phospho-SMAD2 (S457) & phospho-SMAD3 (S423/425) in ascending #AorticAneurysm with #BicuspidAorticValve or #UnicuspidAorticValve
How about TGFβ2/3?
As a comparison, in #TricuspidAorticValve aorta, diameter and elastin break correlate well with increased TGFβ1 level or p-SMAD2/3 levels
Dr. Brittany Balint & Hans-Joachim Schäfers lab, Sci Rep 2022
https://www.nature.com/articles/s41598-022-19335-w
Airway #SmoothMuscleCell forms Collagen III microniche⏫🫁#Metastasis of #BladderCancer
via DDR1-HSP90-Stat3 axis
In primary #MuscleInvasiveBladderCarcinoma Collagen I-DDR1 axis⏫tumor invasiveness
Dr. Keith Syson Chan lab Nature Comms 2019
https://www.nature.com/articles/s41467-019-09878-4
Sea star single-cell sequencing shines light on germ cell specification
A Research Highlight showcasing new work from Stephany Foster, Gary Wessel and colleagues
Read the full Techniques and Resources article, ‘Single-cell RNA-sequencing analysis of early sea star development’ here:
AORTA score, a predictive model trained +common features (age/sex/BP...) in >30k #UKBiobank👤 explains 28-33% #AscendingAorticDiameter
Dr. James Pirruccello
Dr. Mark Lindsay @MarkELindsay Dr. Patrick Ellinor
JAMA 2022
https://jamanetwork.com/journals/jama/article-abstract/2798406
Enjoy the great🧵 by Dr. James Pirruccello
https://twitter.com/jpirruccello/status/1592596235751665666
cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis
RT @GRC_CMM
Hey #cilia & #centriole tweeps- we are just under two weeks from our deadline ⏳December 5th⏳ for abstracts for talk slots at 2023 GRC Cilia, Mucus and Mucociliary meeting in Barga, Italy! #RareDisease #Therapeutics #Biophysics #Biofilms #Mucus #CF #PCD https://www.grc.org/cilia-mucus-and-mucociliary-interactions-conference/2023/
Abdominal Aortic Calcification in #UKBiobank
38264👤
#MachineLearning to measure AAC
-Physio/Biochem predictors
-Cardiovascular outcomes
-Genetics TWIST1/HDAC9, FGF9, NAV1, APOE
Dr. Madeleine Cule & Eugene Melamud lab Frontiers Cardiovascular Medicine 2022
https://www.frontiersin.org/articles/10.3389/fcvm.2022.1003246/full
Cardiovascular biologist, Dr. J. Geoffrey Pickering lab, Robarts Research Institute, Western University, London, Ontario, Canada
https://scholar.google.ca/citations?hl=en&user=IbrDx00AAAAJ&view_op