Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'I said, “I’m not really sure I want to do a cop show.” And Levinson said: “This is about the homicide detectives. They’re thinking cops. There’s no gun battles, there’s no car chases.” And I said: “That’s impossible. I’ll do it.”
Obesity and #covid19 vaccination.
"Here we focus on individuals with severe obesity (those at highest risk). We conducted a prospective, longitudinal study that allowed us to demonstrate that, although initial and peak responses were similar in individuals with severe obesity and individuals with normal weight, there was accelerated decline in antibody levels over time that correlated with increased frequency of hospitalization and mortality from breakthrough infections."
'They observed the significant induction of IFNβ and other inducible chemokines in the medium of primary microglia treated with tau fibrils, which was abrogated by the genetic ablation of Cgas. This raised a question: how does tau protein activate this DNA sensor? Through a series of clever in vitro experiments, the authors demonstrated that tau fibrils localize to microglial lysosomes and mitochondria and that they promote the release of mitochondrial DNA (mtDNA) to the cytosol'
CART cells beyond cancer - my latest Clinical Pipeline column for Nature Medicine is out. CAR T cell technology in humans was first tried for HIV in the 90s. Now veteran HIV researchers are giving them another shot.
#immunotherapy #publichealth #hiv #Immunology #cartcells
#ScienceCommunication #SciComm #InfectiousDisease
Potentially good news that the EU is considering to move beyond #OpenAccess mandates and do away with author publication fees - and fund scientific publication directly.
To me, one problem in the way we talk about this is the tendency to discuss "journals" as a monolithic entity. On a previous episode of the #EMBOPodcast Adriano Aguzzi, Thomas Lemberger & I discussed if funding agencies should establish stricter parameters for which journals could be funded. The community can rate what matters - this is the sort of thing that could give DORA principles some teeth for example. Quality peer review, track record of publishing reliable work, inclusivity, tools for data analysis, etc.
If you want to jump to this bit in the episode ("From Prions to Preprints"), go to minute 19.
'Arthur Bispo do Rosario, a former Marine Corps signalman, boxer, tram cleaner and domestic worker in Rio de Janeiro, had no interest in defining his extensive activities as art. His unusual embroidered garments and textiles, ingenious assemblages and use of language had a higher purpose: Bispo was Jesus Christ, according to angels who visited him the night of Dec. 22, 1938, and instructed him to record, or possibly replicate reality. Thus, the title of his first retrospective in the United States, at the Americas Society in Manhattan: “Bispo do Rosario: All Existing Materials on Earth.”
https://www.nytimes.com/2023/05/05/arts/design/bispo-do-rosario-brazilian-artist.html
The East River, by @madparreira
#Print #Printmaking #handmade #printmakingart #artgallery #artmastodon
"It is conceivable that, although extensive genetic and epigenetic evolution occurs within cancer models, such evolution might not translate into biologically meaningful cellular properties. That is, this phenomenon could represent a molecular curiosity with little practical implication. Unfortunately, this does not seem to be the case. Genomic changes that arise throughout model propagation have been associated with marked phenotypic changes across all cancer model types"
John le Carré did not appreciate Clive James' reviews. (from "A Private Spy. The letters of John le Carré", edited by Tim Cornwell). #Books #Bookshelf #Reader #JohnLeCarre #Bookclub #literarycriticism #bookstodon
'In this Essay, we discuss recent findings related to changes in the metabolic functions of immune cells (immunometabolism), particularly mitochondrial dysfunction, in innate and adaptive immune cells and their contribution to the generation of autoimmunity, with emphasis on systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA)'
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002084
@mucida The paper also has a very interesting evolutionary scenario
"Unbiased phylogenetic analyses indicated that this family and its receptors28 share greater sequence/structure homology to IFN and IFN-receptors than other cytokines/cytokine-receptors (Figures S1A and S1B; Table S3). Notably, the heterodimeric receptor subunits of the IFN and IL-10 families also sub-clustered, suggestive of a common ancestral heterodimeric receptor specific to these two families (Figure S1B). In contrast to IFNs, however, the IL-10 cytokine family has not been as clearly linked to pathogens/danger signals. This raises the tantalizing possibility that, during evolution, these pathways may have bifurcated from a common ancestor to cope with the increasing diversity of pathogens and injuries."
'We now provide compelling evidence that in hypoxic conditions, an autocrine IL-24/IL-24-receptor signaling/STAT3 loop is induced, which then sustains the HIF1α-mediated expression of epidermal IL-24. In turn, IL-24 acts in an autocrine and paracrine fashion to coordinate re-epithelialization, re-vascularization, dermal fibroblast proliferation, and collagen deposition to restore the damaged tissue to homeostasis.'
Liu, @mucida, Fuchs et al
I wrote about RSV vaccines in my #NatureMedicine column in February.
Very good news this week with the FDA approval of GSK's RSV vaccine for adults 60 and over - it's the first approved RSV vaccine.
https://edition.cnn.com/2023/05/03/health/first-rsv-vaccine-approved/index.html
Several other candidate RSV vaccines are at a late stage of development, including mRNA based vaccines. The next big thing to watch for are those seeking to protect newborns and infants by maternal immunisation.
#RSV #Vaccine #RespiratoryVirus #drugdevelopment #Pharma #Immunology
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
