Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
I hate to contradict Chuck D & Terminator X, but *do* believe the hype. Octavia Butler is an amazing writer. This one is Toni Morrison by way of Philip K Dick. #Books #Book #Bookshelf #bookstodon
Location location location
"Here, we show that NET1 mRNA location in combination with the rate of its translation can influence the ability of competing domains to determine the targeting of the newly synthesized protein, by favoring binding to specific partners. This RNA-based partner-selection mechanism provides a robust means of controlling protein function."
#MolecularBiology #Translation #RNA
Toto, I've a feeling we're not in New York anymore.
Cork, right after the harvest.
"A worker sleeps on a cart full of chickens at a wholesale poultry market in Mumbai, August 2010. Photograph: Danish Siddiqui/Reuters”
'For example, loss of function of the microglial gene Trem2 renders microglia dysfunctional and causes an early-onset neurodegenerative syndrome, and Trem2 variants are among the strongest genetic risk factors for AD. Thus, restoring microglial function represents a rational therapeutic approach. Here, we show that systemic hematopoietic cell transplantation followed by enhancement of microglia replacement restores microglial function in a Trem2 mutant mouse model of AD.'
#Alzheimer #NeurodegenerativeDisease #Microglia #Neuroimmunology
https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(23)00251-5#%20
"This series of prints was created between 2017 and 2021 and consists of several aquatints of stages, doors, caves or forests, where figures have been inserted through the technique of chine-collé, and colours added through viscosity printing."
#print #Printmaking #prints #printmaker #Aquatint #artgallery #artmastodon
'In a scattered show, the eye gravitates to the mysteriously poetic, as in a photographic series of Central American and Mexican ruins by the Argentine artist Leandro Katz. Katz retraced the travels of British artist-explorer Frederick Catherwood, who in the 19th century made exquisite drawings of ancient Mayan cities and published them for an exotica-obsessed audience back home.'
https://www.ft.com/content/8f7b9774-8112-46b0-b097-395c4ac388b9
“Developing a structure is seldom that simple. Almost always there is considerable tension between chronology and theme, and chronology traditionally wins. The narrative wants to move from point to point through time, while topics that have arisen now and again across someone’s life cry out to be collected. They want to draw themselves together in a single body, in the way that salt does underground. But chronology usually dominates. On tablets in Babylonia, most pieces were written that way, and nearly all pieces are written that way now.”
- John McPhee, Draft No. 4
"The effects of climate change driven by human activity are now part of the daily news cycle, and time is running out for decisive action."
Lab & academia's responsibilities in the climate emergency. A privilege to collaborate with @mucida & Rachel on this Nature Immunology commentary.
Box with rabbit, glazed stoneware by @hunchbacksociety
These ads are all over NY. To learn the history of this new class of weight loss & diabetes drugs, listen to my conversation with one of the pioneers in the field, Matthias Tschöp @helmholtz_munich.
Scroll down the page at the link below to hear “Obesity is a Brain Disease":
https://www.helmholtz-munich.de/en/helmholtz-pioneer-campus
#DrugDevelopment #Obesity #Diabetes #Metabolism #SciComm #SciencePodcast
The most recent Podcast I produced for EMBO was with Pavel Tomancak (and EMBO's Thomas Lemberger). One detail that might get missed in a wide ranging conversation about science, policy, science fiction and more was Pavel's passing comment on how one important consideration in his decision to return to Europe after a very productive time at UC Berkeley were serious reservations about the US healthcare system.
#Drosophila #OpenScience #DevelopmentalBiology #EMBOPodcast
My new Clinical Pipeline column is out in Nature Medicine.
It's on JAK inhibitors for alopecia - and at the black box safety warning the FDA attached to this entire class of drugs.
#Immunology #drugdiscovery #drugdevelopment #alopecia
As long as they cough up their share of the rent
"In June a Paris official made an announcement: the city would form a committee to look into the prospect of “cohabitating” with rats."
https://www.nybooks.com/articles/2023/08/17/whack-a-rat-the-rats-of-paris-vergopoulos/
"Maps 1 & 4 The Conan Map (Brest, France, 16th Century)
This Renaissance print is a copy of a vellum drawn circa 1156 at the behest of Conan IV (“the Black”), Duke of Brittany, during a dynastic dispute with King Henry II of England, who was also Count of neighboring Anjou. As shown in the inset, the image’s purpose is solely to assert power and legitimacy. The multiple lines shown in the inset (the only remaining panel of a set of three) proclaim the conquest and rule of the corresponding regions by the Duke and his kinsmen in the House of Penthièvre."
#Art #Print #Printmaking #Etching #Handmade #Cartography#ArtGallery #Maps #artmastodon
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
